Downstream synthetic route of 14813-01-5

14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,14813-01-5

1000ml three necked flask, N-benzyl-3-hydroxypiperidine (95.6 g, 0.5 mol), 2-Butanone (478 ml) was added dropwise a solution of L-CSA (58 g, 0.25 mol) in 290 ml of 2-butanone at room temperature Stirring for 1 hour, precipitation of solid appeared, 0 heat 2 hours, filtration, 2-butanone 30ml washing,Dried to obtain 88 g of (S) -1-benzyl-3-hydroxypiperidine camphorsulfonate. (Ee: 93%) (theory: 105.9 g).

14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference:
Patent; ABA Chemicals Corporation; Lin, ZhiGang; Xu, Jun; Liu, YanQin; Que, limin; Jiang, yueheng; CAI, Tong; (13 pag.)CN103864673; (2016); B;,
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