Downstream synthetic route of 14813-01-5

14813-01-5, 14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Then, 11.8 g of the 1-benzyl-3-hydroxypiperidine and 5.6 g of diketene were reacted similarly as in Reference Example 1, and the reaction product was purified by silica gel column chromatography (eluent:chloroform:methanol=9:1 v/v), to obtain 10.65 g of acetoacetic acid-N-benzyl-3-piperidinyl ester (yield: 62.5%). This was used in the reaction of Example 4 without distillation. NMR spectrum (CDCl3, delta): 1.30-1.90(4H, broad), 2.10-2.95(4H, broad), 2.27(3H, s), 3.43(2H, s), 3.54(2H, s), 4.73-5.2(1H, broad), 7.30(5H, s)

14813-01-5, 14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference:
Patent; Kyowa Hakko Kogyo Co., Ltd.; US4448964; (1984); A;,
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