147539-41-1, tert-Butyl 4-(methylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of Cbz-protected tert-leucine (500 mg, 1.9 mmol) in dichloromethane (10 ml) was added PyAOP (1. 08 g, 2.1 mmol), HOAt (26 mg, 0. 19 mmol), triethylamine and 4-Methylamino-piperidine-1-carboxylic acid tert-butyl ester (606 mg, 2.8 mmol). The reaction mixture was stirred for 18 h at Rt. The solvent was removed in vacuo and the yellow residue was redissolved in dichloromethane (80 ml) and was washed with 1 M hydrochloric acid (2 x 80 ml), 1 M sodium carbonate (2 x 80 ml), brine (1 x 80 mi) and dried over anhydrous magnesium sulphate to yield a clear oil (2 g). Flash chromatography (2percent MeOH, dichloromethane) yielded the title compound as a white foam (870 mg, 100percent) which contained a slight impurity. HPLC. 6.9 min (85percent); LRMS: +ve ion 462 (M+1, 5percent), 484 (M+Na, 20percent). The compound was progressed to the next step without any further purification.
147539-41-1, 147539-41-1 tert-Butyl 4-(methylamino)piperidine-1-carboxylate 15380702, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; BRITISH BIOTECH PHARMACEUTICALS LTD; WO2003/89412; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem