143900-43-0, (R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
24B: (f?)-3-Methanesulphonyloxypiperidine-1-carboxylic acid fe/f-butyl ester To a solution of (f?)-3-hydroxypiperidine-1-carboxylic acid terf-butyl ester (6.51 g,32.3 mmol) and triethylamine (6.8ml, 1.5 mol eq) in dichloromethane (70ml) at 0 0C was added a solution of methanesulphonyl chloride (3.73 ml, 1.5 mol) in dichloromethane (30 ml) over 30 minutes. The reaction was stirred at 0 0C for 2 hours. Saturated sodium hydrogen carbonate (100 ml) was added slowly. The organic phase was separated, washed with brine and dried over magnesium sulphate. Evaporation under reduced pressure yielded (f?)-3-methanesulphonyloxypiperidine-1-carboxylic acid terf-butyl ester,9.03g (100%). NMR (CDCI3 7.27d) m 4.73/(1 H), m 3.63/(2H), m 3.44/(1 H), m 3.32/(1 H), s 3.05/(3H), m 1.95/(2H), m 1.83/(1 H), m 1.54/(1 H), s 1.46/(9H)
The synthetic route of 143900-43-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; N.V. ORGANON; WO2007/65916; (2007); A1;,
Piperidine – Wikipedia
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