142752-12-3, 1-(4-Aminophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 141-{4-fluoro-2-[4-(4-hydroxypiperidin-1-yl)phenylamino]benzyl}-3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethylimidazolidine-2,4-dione; hydrochloride; 0.16 g of compound 3.2 was admixed with 0.10 g of 1-(4-aminophenyl)-piperidin-4-ol, 8 mg of palladium(II) acetate, 39 mg of 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene and 0.33 g of cesium carbonate, before 10 ml of dry dioxane were added under an argon atmosphere. The mixture was stirred at 80 C. for 6 h. The cooled reaction mixture was filtered with suction, the filtrate was concentrated under reduced pressure and the residue was purified by chromatography (method [RP1]). The eluates were concentrated, admixed with hydrochloric acid in dioxane and freeze-dried. This afforded 1-{4-fluoro-2-[4-(4-hydroxypiperidin-1-yl)phenylamino]benzyl}-3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl imidazolidine-2,4-dione as the hydrochloride (14). Molecular weight (free base) 588.21 (C30H29F5N4O3); retention time Rt=3.91 min. [D]; MS (ESI): 589.52 (MH+)., 142752-12-3
The synthetic route of 142752-12-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SANOFI-AVENTIS; US2011/46105; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem