Downstream synthetic route of 142643-29-6

The synthetic route of 142643-29-6 has been constantly updated, and we look forward to future research findings.

142643-29-6, 3-(Boc-aminomethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

64a) {1-[2-(3-Chloro-6-methoxy-quinolin-4-yl)-2-hydroxy-ethyl]-piperidin-3-ylmethyl}-carbamic acid tert-butyl ester (enantiomer1)Epoxide (56f) (900 mg), 3-(N-Boc-aminomethyl)piperidine (819ing) i potassium carbonate (555 mg) and lithium perchlorate (405mg) were suspended in DMF (9 ml) and heated in the microwave for35 minutes at 130C. The mixture was concentrated, the residuedissolved in ethyl acetate and washed with water and brine. Theorganic layer was dried over magnesium sulfate, filtered andevaporated. The residue was purified by flash chromatography(silica gel, dichloromethane/methanol 97:3) to give the desiredproduct (1.6 g).MS (El): m/z: 450 [M+H]+, 142643-29-6

The synthetic route of 142643-29-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MORPHOCHEM AKTIENGESELLSCHAFT FUeR KOMBINATORISCHE CHEMIE; WO2006/21448; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem