With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245648-32-1,tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
NaBH4 (76 mg; 2 mmol; 2 eq.) was added at -10°C to a solution of 1-Boc-2- trifluoromethyl- piperidin-4-one (Small Molecules inc.) (267 mg; 1 mmol; 1 eq.) in MeOH (8 mL) and the reaction mixture was stirred at -10°C for 1 hour. Sat. aq. NH4CI (3 mL) was added and the resulting mixture was allowed to return to room temperature. The MeOH was evaporated in vacuo and the resulting aqueous layer extracted with DCM (4x). The combined organics were washed with brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound (269 mg, 100percent) as a colourless oil. 1H NMR (CDCI3) delta 4.74 (br s, 1 H), 4.19-3.93 (m, 2H), 3.42-3.17 (m, 1H), 2.14-1.90 (m, 2H), 1.90-1.52 (m, 3H), 1.52-1.37 (m, 9H)., 1245648-32-1
1245648-32-1 tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate 71607278, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; MERCK PATENT GMBH; SWINNEN, Dominique; MONTAGNE, Cyril; POMEL, Vincent; QUATTROPANI, Anna; MOLETTE, Jerome; GERBER, Patrick; WO2013/91773; (2013); A1;,
Piperidine – Wikipedia
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