1038866-44-2, Spiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 54(S)-1-(6-(4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-6-yloxy)pyrimidin-4-yl)-spiro[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one; 59 mg (0.23 mmol) spiro[piperidin-4,4′-pyrido[2,3-d][1,3]oxazin]-2′(1’H)-one hydrochloride, 70 mg (0.21 mmol) (S)-6-(6-chloropyrimidin-4-yloxy)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazole and 0.12 mL (0.70 mmol) DIPEA in 2.0 mL DMF were stirred overnight at 40 C. The reaction mixture was purified by preparative HPLC-MS. The fractions containing product were partially evaporated down i.vac. and neutralised with 4M sodium hydroxide solution. The precipitate formed was suction filtered, washed and dried.Yield: 21 mg (18% of theory)ESI-MS: m/z=514 (M+H)+ Rt (HPLC): 1.09 min (method B)
1038866-44-2, As the paragraph descriping shows that 1038866-44-2 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/88755; (2012); A1;,
Piperidine – Wikipedia
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