With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
General procedure: In a grinding jar, 4-(diphenylamino)benzaldehyde (0.015 mol, 4.10 g) were combined with [(4-ethenylphenyl)methyl] phosphonic acid diethyl ester (0.01 mol, 2.53 g), t-BuOK (0.02 mol, 2.76 g) and the 7 mm stainless steel balls. The grinding jar was placed in a planetary ball-mill and stirred at 550 runs per minute during 2 h at room temperature. Then 60 mL DCM was added in the jar and the mixture was washed twice with 200 mL water. The organic layer was dried over MgSO4, concentrated under vacuum. The residue was isolated by column chromatography on silica gel using petroleum ether/ethyl acetate (10:1) to afford 3.06 g of the titled compound as a light yellow needle crystal. Yield 80.2%., 10338-57-5
The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Huang, Jiu-Qiang; Cai, Zhi-Bin; Jin, Fan; Li, Sheng-Li; Tian, Yu-Peng; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 154; (2016); p. 164 – 170;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem