10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Prepared with LiHMDS as Base: A solution of product from Example 32B (2 g, 6 mmol) in tetrahydrofuran (15 ml) was cooled to -20 to -22 C. under a nitrogen atmosphere. A solution of lithium hexamethyldisilazide (LiHMDS) (1.0M in THF, 7.2 ml, 7.2 mmol) was added, dropwise, maintaining the temperature at -20 to -22 C. After the addition, the solution was stirred at -20 to -22 C. for 2 hours. A solution of product from Example 7 (2.26 g, 8 mmol) in tetrahydrofuran (10 ml) was added, dropwise, at -20 to -22 C. The reaction was stirred for an additional 2.5 hours while maintaining the low temperature. The mixture was quenched with saturated ammonium chloride (15 ml) and extracted with ethyl acetate (3*10 ml). The organic extract was dried over anhydrous magnesium sulfate, filtered through silica pad and concentrated to a small residual volume. n-Heptane (10 ml) was add and the solution was left overnight at room temperature to produce 2.4 g (69%) of the product as white crystals. HPLC: 90% pure., 10315-06-7
10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Sandanayaka, Vincent P.; Zask, Arie; Venkatesan, Aranapakam M.; Baker, Jannie L.; Krishnan, Lalitha; Megati, Sreenivasulu; Zeldis, Joseph; US2002/99035; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem