On November 24, 2021, Dorsheimer, Julia R.; Ashley, Melissa A.; Rovis, Tomislav published an article.Synthetic Route of 362703-57-9 The title of the article was Dual Nickel/Photoredox-Catalyzed Deaminative Cross-Coupling of Sterically Hindered Primary Amines. And the article contained the following:
Authors report a method to activate α-3° amines for deaminative arylation via condensation with an electron-rich aldehyde and merge this reactivity with nickel metallaphotoredox to generate benzylic quaternary centers, a common motif in pharmaceuticals and natural products. The reaction is accelerated by added ammonium salts. Evidence is provided in support of two roles for the additive – inhibition of nickel black formation and acceleration of the overall reaction rate. Authors demonstrate a robust scope of amine and haloarene coupling partners and show an expedited synthesis of ALK2 inhibitors. The experimental process involved the reaction of tert-Butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate(cas: 362703-57-9).Synthetic Route of 362703-57-9
The Article related to primary amine deaminative cross coupling nickel photoredox, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: General and other aspects.Synthetic Route of 362703-57-9
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem