Discovery of Tenofovir disoproxil

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 201341-05-1. SDS of cas: 201341-05-1.

Chemistry, like all the natural sciences, SDS of cas: 201341-05-1, begins with the direct observation of nature¡ª in this case, of matter.201341-05-1, Name is Tenofovir disoproxil, SMILES is O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O, belongs to piperidines compound. In a document, author is Zhong, Feng, introduce the new discover.

Catalytic Asymmetric Construction of Halogenated Stereogenic Carbon Centers by Direct Vinylogous Mannich-Type Reaction

A catalytic asymmetric vinylogous Mannich-type reaction of gamma-halo-alpha,beta-unsaturated N-acylpyrazoles and N-Boc-aldimines was disclosed, which afforded an array of halogenated (F-, Cl-, and Br-) allylic stereogenic carbon centers in high yields with good to high regio-, diastereo-, and enantioselectivities. The brominated product served as a suitable electrophile for common S(N)2 nucleophilic substitution and copper mediated S(N)2′ allylic alkylation with metal reagents. The utility of present methodology was demonstrated by the asymmetric synthesis of a common intermediate toward the synthesis of two chiral 2,3-disubstituted piperidine pharmaceuticals.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 201341-05-1. SDS of cas: 201341-05-1.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem