I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives published in 2021. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane, Reprint Addresses N’Da, DD (corresponding author), North West Univ, Ctr Excellence Pharmaceut Sci, ZA-2520 Potchefstroom, South Africa.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically used drugs. As a result, there is a dire need for the development of new antileishmanial drugs that are safe, affordable, and efficient. In this study, two new series of synthesized quinazolinone derivatives were investigated as potential future antileishmanial agents, by assessing their activities against theLeishmania(L.)donovaniandL. majorspecies. The cytotoxicity profiles of these derivatives were assessed in vitro on Vero cells. The compounds were found to be safer and without any toxic activities against mammalian cells, compared to the reference drug, halofuginone, a clinical derivative of febrifugine. However, they had demonstrated poor antileishmanial growth inhibition efficacies. The two compounds that had been found the most active were the mono quinazolinone2dand the bisquinazolinone5bwith growth inhibitory efficacies of 35% and 29% for theL. majorandL. donovani9515 promastigotes, respectively. These outcomes had suggested structural redesign,inter aliathe inclusion of polar groups on the quinazolinone ring, to potentially generate novel quinazolinone derivatives, endowed with effective antileishmanial potential.
Welcome to talk about 177-11-7, If you have any questions, you can contact Prinsloo, IF; Zuma, NH; Aucamp, J; N’Da, DD or send Email.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane
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