Chemistry is an experimental science, Safety of 2-(Piperidin-4-yl)benzo[d]oxazole, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 51784-03-3, Name is 2-(Piperidin-4-yl)benzo[d]oxazole
A series of benzoxazoles with a nitrogen-containing heterocyclic substituent at the 2-position was prepared and evaluated for 5-HT3 partial agonist activity on isolated guinea pig ileum. The nature of the substituent at the 5-position of the benzoxazole ring affected the potency for the 5-HTs receptor, and the 5-chloro derivatives showed increased potency and lowered intrinsic activity. 5-Chloro-7-methyl-2-(4-methyl-1- homopiperazinyl)benzoxazole (6v) exhibited a high binding affinity in the same range as that of the 5-HT3 antagonist granisetron, and its intrinsic activity was 12% of that of 5-HT. Compound 6v inhibited 5-HT-evoked diarrhea but did not prolong the transition time of glass beads in the normal distal colon even at a dose of 100 times the ED50 for diarrhea inhibition in mice. Compounds of this type are expected to be effective for the treatment of irritable bowel syndrome without the side effect of constipation.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of 2-(Piperidin-4-yl)benzo[d]oxazole, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 51784-03-3, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H15073N – PubChem