A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 4-Morpholinopiperidine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 53617-35-9, Name is 4-Morpholinopiperidine, molecular formula is C9H18N2O. In a Patent, authors is £¬once mentioned of 53617-35-9
A preparation method of leti nepal (by machine translation)
The invention discloses a method for preparing leti nepal. The method of the invention to 2 – (4 – bromo – 3 – hydroxy-phenyl) acetic acid ethyl ester as the raw material, with the trifluoromethyl anhydride to trifluoromethanesulfonic acid esterification reaction, to obtain the trifluoromethanesulfonic acid ester compound; then with the other raw materials 4 – (4 – piperidinyl) morpholine substitution reaction, to obtain 2 – {4 – bromo – 3 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] phenyl} ethyl acetate; then the double-methylation reaction and hydrolysis reaction, the obtained 2 – {4 – bromo – 3 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] phenyl} – 2 – methyl propionic acid with malonic acid butyl uncle Shan condensation reaction, to obtain 4 – {4 – bromo – 3 – [4 – (morpholine – 4 – yl) piperidine – 1 – yl] phenyl} – 4 – methyl – 3 – oxo-pentanoic acid tert-butyl; through the use of classical reaction Fischer indole synthesis method, carbonyl and phenyl hydrazine in the next cyclization to form the indole acid catalysis mother nucleus, and finally through the cyclization reaction, sediment and catalytic coupling reaction, to prepare the leti nepal, the route method is reasonable in design, cheap, reaction condition is easy to effectively control. (by machine translation)
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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H9722N – PubChem