Discovery of 1-Boc-5-Ethyl-2,4-dioxopiperidine

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C12H19NO4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 845267-80-3, in my other articles.

Chemistry is an experimental science, COA of Formula: C12H19NO4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 845267-80-3, Name is 1-Boc-5-Ethyl-2,4-dioxopiperidine

First Cdc7 kinase inhibitors: Pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery

Cdc7 kinase is a key regulator of the S-phase of the cell cycle, known to promote the activation of DNA replication origins in eukaryotic organisms. Cdc7 inhibition can cause tumor-cell death in a p53-independent manner, supporting the rationale for developing Cdc7 inhibitors for the treatment of cancer. In this paper, we conclude the structure-activity relationships study of the 2-heteroaryl-pyrrolopyridinone class of compounds that display potent inhibitory activity against Cdc7 kinase. Furthermore, we also describe the discovery of 89S,[(S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoro-ethyl)-1,5,6,7- tetrahydropyrrolo[3,2-c]pyridin- 4-one], as a potent ATP mimetic inhibitor of Cdc7. Compound 89S has a Ki value of 0.5 nM, inhibits cell proliferation of different tumor cell lines with an IC50 in the submicromolar range, and exhibits in vivo tumor growth inhibition of 68% in the A2780 xenograft model.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C12H19NO4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 845267-80-3, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H20011N – PubChem