Recently I am researching about RAPID COLORIMETRIC ASSAY; ANTIPROLIFERATIVE EVALUATION; MOLECULAR HYBRIDIZATION; ANALOGS; CANCER; CAMPTOTHECIN; ALKALOIDS; MECHANISM; DISCOVERY; APOPTOSIS, Saw an article supported by the Ministry of Science and Technology, TaiwanMinistry of Science and Technology, Taiwan [MOST104-2113-M-038-001]; Taipei Medical University [TMUTOP103003-1]; National Defense Medical Center [TMU-NDMC-104-02]; NIH-NCIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI). Published in ELSEVIER in AMSTERDAM ,Authors: Chen, TC; Yu, DS; Chen, SJ; Chen, CL; Lee, CC; Hsieh, YY; Chang, LC; Guh, JH; Lin, JJ; Huang, HS. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane
Several 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives have been designed which is replacing side chains with different groups containing oxygen, nitrogen or sulfur atoms. Substitution of C-6 on the starting structure, 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one, using apposite nucleophilic group with a suitable base or acid could be obtained 28 novel tetracyclic azafluorenone derivatives. The cytotoxic activity of these analogues was examined in cancer cell lines by MTT assay and compounds 4, 5, 13, and 26 were selected to evaluate in topoisomerase I drug screening assay, respectively. At the same time, 17 compounds were selected for NCI-60 anticancer drug screen to prevent the narrower concept of an in vitro screening model. Its worth to find that 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (12) showed greater cytotoxicity than another azafluorenone derivatives with an average GI(50) of 10.498 mu M over 60 cell lines. We also found that another analogue, 9-chloro-6-(2-methylpiperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (13), exhibited preferential growth inhibition effect toward cancer cell lines and showed a significant inhibitory effect on topoisomerase I. (C) 2016 Production and hosting by Elsevier B.V. on behalf of King Saud University.
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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem