Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 145166-06-9, is researched, Molecular C11H21NO3, about Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors, the main research direction is cycloalkanediamine sulfonyl carbonyl preparation blood coagulation factor Xa inhibitor; indolyl thiazolopyridyl cycloalkanediamine preparation blood coagulation factor Xa inhibitor.Application In Synthesis of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate.
This paper describes the synthesis of orally available potent fXa inhibitors, e.g. cis – or trans-I (X = SO2, CO) by modification of the piperazine part of the lead compound The carbonyl derivatives showed potent fXa activity but not the sulfonyl derivatives Among the compounds synthesized, cyclohexane derivatives and cycloheptane derivatives had potent anticoagulant activity as well as anti-fXa activity. Synthetic study of the optical isomers demonstrated that the (-)-(1R,2S)-isomer (I, X = CO) had more potent activity.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem