On February 29, 2020, Daerr, Markus; Pabel, Joerg; Hoefner, Georg; Mayer, Peter; Wanner, Klaus T. published an article.Safety of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Synthesis and biological evaluation of fluorescent GAT-ligands based on meso-substituted BODIPY dyes. And the article contained the following:
BODIPY dyes are known for their outstanding spectroscopic properties and are therefore established in a range of fluorescence based anal. techniques for in vitro as well as for in vivo measurements. For the first time, the authors designed and synthesized a series of fluorescent ligands for the SLC6 family transporters mGAT1-mGAT4 based on BODIPY dyes as fluorogenic subunits. In the novel series of fluorescent compounds, BODIPY dye subunits are linked with an alkyl chain of three to five carbon atoms that originates from the meso-position of the BODIPY dye to the amino function of different cyclic amines. Screening of these fluorescent probes for their biol. activity as GABA uptake inhibitors of mGAT1-mGAT4 revealed ligands with pIC50 values up to 5.35. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Safety of 4-(4-Chlorophenyl)piperidin-4-ol
The Article related to fluorescent gat ligand bodipy dye, Placeholder for records without volume info and other aspects.Safety of 4-(4-Chlorophenyl)piperidin-4-ol
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem