Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Reference of 2403-88-5.
Cunha, Anna C.;Ferreira, Vitor F.;Vaz, Maria G. F.;Cassaro, Rafael A. Allao;Resende, Jackson A. L. C.;Sacramento, Carolina Q.;Costa, Jessica;Abrantes, Juliana L.;Souza, Thiago Moreno L.;Jordao, Alessandro K. research published 《 Chemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids》, the research content is summarized as follows. Abstract: HSV disease is distributed worldwide. Anti-herpesvirus drugs are a problem in clin. settings, particularly in immunocompromised individuals undergoing herpes simplex virus type 1 infection. In this work, 4-substituted-1,2,3-1H-1,2,3-triazole linked nitroxyl radical derived from TEMPOL were synthesized, and their ability to inhibit the in vitro replication of HSV-1 was evaluated. The nitroxide derivatives were characterized by IR spectroscopy and elemental anal., and three of them had their crystal structures determined by single-crystal X-ray diffraction. Four hybrid mols. showed important anti-HSV-1 activity with IC50 values ranged from 0.80 to 1.32μM. In particular, one of the nitroxide derivatives was more active than Acyclovir (IC50 = 0.99μM). All compounds tested were more selective inhibitors than the reference antiviral drug. Among them, two compounds were 4.5 (IC50 0.80μM; selectivity index CC50/IC50 3886) and 7.7 times (IC50 1.10μM; selectivity index CC50/IC50 6698) more selective than acyclovir (IC50 0.99μM; selectivity index CC50/IC50: 869). These nitroxide derivatives may be elected as leading compounds due to their antiherpetic activities and good selectivity.
2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Reference of 2403-88-5
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem