Cunha, Anna C. published the artcileChemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids, Product Details of C9H17NO, the publication is Molecular Diversity (2021), 25(4), 2035-2043, database is CAplus and MEDLINE.
Abstract: HSV disease is distributed worldwide. Anti-herpesvirus drugs are a problem in clin. settings, particularly in immunocompromised individuals undergoing herpes simplex virus type 1 infection. In this work, 4-substituted-1,2,3-1H-1,2,3-triazole linked nitroxyl radical derived from TEMPOL were synthesized, and their ability to inhibit the in vitro replication of HSV-1 was evaluated. The nitroxide derivatives were characterized by IR spectroscopy and elemental anal., and three of them had their crystal structures determined by single-crystal X-ray diffraction. Four hybrid mols. showed important anti-HSV-1 activity with IC50 values ranged from 0.80 to 1.32μM. In particular, one of the nitroxide derivatives was more active than Acyclovir (IC50 = 0.99μM). All compounds tested were more selective inhibitors than the reference antiviral drug. Among them, two compounds were 4.5 (IC50 0.80μM; selectivity index CC50/IC50 3886) and 7.7 times (IC50 1.10μM; selectivity index CC50/IC50 6698) more selective than acyclovir (IC50 0.99μM; selectivity index CC50/IC50: 869). These nitroxide derivatives may be elected as leading compounds due to their antiherpetic activities and good selectivity.
Molecular Diversity published new progress about 826-36-8. 826-36-8 belongs to piperidines, auxiliary class Natural product, name is 2,2,6,6-Tetramethylpiperidin-4-one, and the molecular formula is C9H17NO, Product Details of C9H17NO.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem