On April 25, 2013, Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E. published a patent.Safety of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate The title of the patent was Preparation of piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors. And the patent contained the following:
The title compounds I [Y and Z = (un)substituted aryl, heteroaryl, 1,3-dihydro-3H-benzimidazol-2-on-yl, etc.; R = H or OH], useful for treating various diseases, syndromes, conditions and disorders, including pain, were prepared E.g., a multi-step synthesis of II, starting from tert-Bu 3-iodoazetidine-1-carboxylate, was described. Exemplified compounds I were tested in the MGL activity assay (data given). Pharmaceutical composition comprising compound I is disclosed. The experimental process involved the reaction of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate(cas: 1251006-64-0).Safety of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate
The Article related to piperidinylazetidine diamide amide preparation monoacylglycerol lipase inhibitor analgesic, inflammatory pain treatment piperidinylazetidine amide preparation monoacylglycerol lipase inhibitor and other aspects.Safety of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem