Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β) was written by Christopher, John A.;Bamborough, Paul;Alder, Catherine;Campbell, Amanda;Cutler, Geoffrey J.;Down, Kenneth;Hamadi, Ahmed M.;Jolly, Adrian M.;Kerns, Jeffrey K.;Lucas, Fiona S.;Mellor, Geoffrey W.;Miller, David D.;Morse, Mary A.;Pancholi, Kiritkant D.;Rumsey, William;Solanke, Yemisi E.;Williamson, Rick. And the article was included in Journal of Medicinal Chemistry in 2009.Recommanded Product: N-Boc-3-(bromomethyl)piperidine This article mentions the following:
The identification and progression of a potent and selective series of isoquinoline inhibitors of IκB kinase-β (IKK-β) are described. Hit-generation chem. based on IKK-β active-site knowledge yielded a weakly potent but tractable chemotype that was rapidly progressed into a series with robust enzyme and cellular activity and significant selectivity over IKK-α. In the experiment, the researchers used many compounds, for example, N-Boc-3-(bromomethyl)piperidine (cas: 193629-39-9Recommanded Product: N-Boc-3-(bromomethyl)piperidine).
N-Boc-3-(bromomethyl)piperidine (cas: 193629-39-9) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Recommanded Product: N-Boc-3-(bromomethyl)piperidine
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem