《Structure-activity relations of arecaidine derivatives on the guinea pig isolated atria》 was published in European Journal of Pharmacology in 1967. These research results belong to Christiansen, Anneliese; Lullmann, Heinz; Mutschler, Ernst. Application of 1690-72-8 The article mentions the following:
The influence of arecaidine esters, arecaidine methiodide esters, dihydroarecaidine esters, and dihydroarecaidine methiodide esters was tested on the amplitude of contraction of elec. stimulated isolated atria from the guinea pig. The amplitude of contraction was reduced by all arecaidine esters. This effect was abolished by atropine. Arecaidine Et ester possessed the highest activity and arecaidine iso-Pr ester was the least active. Like arecaidine Me ester, arecaidine methiodide Me ester showed muscarine-like properties. Quaternary esters with a longer chain showed nicotine-like action or acted as inhibitors. Dihydroarecaidine esters and dihydroarecaidine methiodide esters were antagonists; only dihydroarecaidine Me ester and dihydroarecaidine methiodide Me ester showed muscarine-like action. The experimental process involved the reaction of Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Application of 1690-72-8)
Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Application of 1690-72-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem