Inhibition of angiogenesis by the antifungal drug itraconazole was written by Chong, Curtis R.;Xu, Jing;Lu, Jun;Bhat, Shridhar;Sullivan, David J. Jr.;Liu, Jun O.. And the article was included in ACS Chemical Biology in 2007.Quality Control of 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline This article mentions the following:
Angiogenesis, the formation of new blood vessels, is implicated in a number of important human diseases, including cancer, diabetic retinopathy, and rheumatoid arthritis. To identify clin. useful angiogenesis inhibitors, the authors assembled and screened a library of mostly Food and Drug Administration-approved drugs for inhibitors of human endothelial cell proliferation. One of the most promising and unexpected this was itraconazole, a known antifungal drug. Itraconazole inhibits endothelial cell cycle progression at the G1 phase in vitro and blocks vascular endothelial growth factor/basic fibroblast growth factor-dependent angiogenesis in vivo. In attempts to delineate the mechanism of action of itraconazole the authors found that human lanosterol 14α-demethylase (14DM) is essential for endothelial cell proliferation and may partially mediate the inhibition of endothelial cells by itraconazole. Together, these findings suggest that itraconazole has the potential to serve as an antiangiogenic drug and that lanosterol 14DM is a promising new target for discovering new angiogenesis inhibitors. In the experiment, the researchers used many compounds, for example, 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3Quality Control of 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline).
4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline (cas: 74852-62-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 4-(4-(4-Methoxyphenyl)piperazin-1-yl)aniline
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics