Merging Synthesis and Enantioselective Functionalization of Indoles by a Gold-Catalyzed Asymmetric Cascade Reaction was written by Chiarucci, Michel;Mocci, Rita;Syntrivanis, Leonidas-Dimitrios;Cera, Gianpiero;Mazzanti, Andrea;Bandini, Marco. And the article was included in Angewandte Chemie, International Edition in 2013.COA of Formula: C12H15NO3S This article mentions the following:
In the presence of a nonracemic bis[chlorogold(I)] DTBM-SEGPHOS complex and silver(I) bis(trifluoromethylsulfonyl)imide, (Z)-(hydroxyalkynyl)phenylaminobutenols I [R = R1 = H, Me, Et, Bu; RR1 = (CH2)2X(CH2)2, 1,1′-biphenyl-2,2′-diyl; R2 = H, Me, F3C, F; R3 = H, Cl; R4 = H, Me; X = CH2, CH2CH2, O, TsN; Ts = 4-MeC6H4SO2] underwent chemoselective and enantioselective cyclocondensation reactions to give nonracemic vinylmorpholinoindoles II [R = R1 = H, Me, Et, Bu; RR1 = (CH2)2X(CH2)2, 1,1′-biphenyl-2,2′-diyl; R2 = H, Me, F3C, F; R3 = H, Cl; R4 = H, Me; X = CH2, CH2CH2, O, TsN] in 30-94% yields and in 78-96% ee. The structure of II (RR1 = CH2CH2NTsCH2CH2; R2 = R3 = R4 = H) was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 1-Tosylpiperidin-4-one (cas: 33439-27-9COA of Formula: C12H15NO3S).
1-Tosylpiperidin-4-one (cas: 33439-27-9) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.COA of Formula: C12H15NO3S
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem