Chen, Xiaoqi published the artcileDiscovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2, Computed Properties of 137419-24-0, the main research area is MCHR 2 antagonist carbazolylmethyl spiroindanpiperidine preparation.
A series of carbazoylylmethylindanspiropiperidines were synthesized and evaluated as MCHR2 antagonists using a FLIPR assay. The pharmacokinetic properties of selected compounds have also been studied. This effort led to the discovery of potent and specific MCHR2 antagonists. Thus, I demonstrated good pharmacokinetic properties across rat, beagle dog and rhesus monkey and had a favorable selectivity profile against a number of other receptors. These MCHR2 antagonists are considered appropriate tool compounds for study of the function of MCHR2 in vivo.
Bioorganic & Medicinal Chemistry Letters published new progress about. 137419-24-0 belongs to class piperidines, name is tert-Butyl spiro[indene-1,4′-piperidine]-1′-carboxylate, and the molecular formula is C18H23NO2, Computed Properties of 137419-24-0.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem