Chen, Ching-Hsiu published the artcileMetabolism of N-ethyl-3-piperidyl benzilate in rats, Application In Synthesis of 13444-24-1, the publication is Journal of Pharmaceutical Sciences (1977), 66(7), 931-5, database is CAplus and MEDLINE.
The metabolic fate of N-ethyl-3-piperidyl benzilate-HCl (I) [5957-24-4] and its potential metabolites 3-piperidyl benzilate-HCl (II) [60573-85-5], N-ethyl-3-hydroxy-piperidine-HCl (III) [5396-73-6], and 3-hydroxypiperidine-HCl (IV) [64051-79-2] was studied. Incubation of I with rat liver homogenates resulted in the formation of II and III. Only a trace of unchanged drug appeared in the urine after intraperitoneal injection of I. Approx. 9% of the injected dose of I was excreted in urine as III and 2% in the form of metabolites that produced III after acid hydrolysis. After i.p. injection of II n rats, 18% of the dose was excreted in urine as IV. Approx. 26% of the injected dose of III was present in urine as the unchanged drug, and 63% of the dose was excreted in the urine in the form of conjugates that produced III on acid hydrolysis. Urine of rats injected with IV contained approx. 50% of the injected dose as the unchanged drug and 50% of the dose in the form of a conjugate that produced IV on acid hydrolysis. The identity of the metabolites in extracts from urine was established by GLC-mass spectrometry. Thus, hydrolysis was one metabolic pathway for I and II. The major routes of elimination of these compounds are not yet known and may include excretion in feces or metabolic transformations resulting in the degradation of the piperidine ring.
Journal of Pharmaceutical Sciences published new progress about 13444-24-1. 13444-24-1 belongs to piperidines, auxiliary class Piperidine,Alcohol, name is 1-Ethylpiperidin-3-ol, and the molecular formula is C7H15NO, Application In Synthesis of 13444-24-1.
Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem