So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chowdhury, Morshed A.; Abdellatif, Khaled R. A.; Dong, Ying; Das, Dipankar; Suresh, Mavanur R.; Knaus, Edward E. researched the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2 ).Safety of 1-(2-chloropyridine-4-yl)ethanone.They published the article 《Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity》 about this compound( cas:23794-15-2 ) in Journal of Medicinal Chemistry. Keywords: dihydropyridone difluoromethyl derivative preparation cyclooxygenase lipoxygenase inhibition antiinflammatory activity; celecoxib analog preparation cyclooxygenase lipoxygenase dual inhibition antiinflammatory activity. We’ll tell you more about this compound (cas:23794-15-2).
A novel class of hybrid cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LOX) inhibitory anti-inflammatory agents I (R = Me, NH2) was designed. Replacement of the tolyl ring present in celecoxib by the N-difluoromethyl-1,2-dihydropyrid-2-one moiety provided compounds showing dual selective COX-2/5-LOX inhibitory activities. Sulfonamide I (R = NH2) exhibited good anti-inflammatory (AI) activity (ED50 = 27.7 mg/kg po) that compares favorably with the reference drugs celecoxib (ED50 = 10.8 mg/kg po) and ibuprofen (ED50 = 67.4 mg/kg po). The N-difluoromethyl-1,2-dihydropyrid-2-one moiety provides a novel 5-LOX pharmacophore for the design of cyclic hydroxamic mimetics for exploitation in the development of COX-2/5-LOX inhibitory AI drugs.
Different reactions of this compound(1-(2-chloropyridine-4-yl)ethanone)Safety of 1-(2-chloropyridine-4-yl)ethanone require different conditions, so the reaction conditions are very important.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem