Rescourio, Gwenaella; Gonzalez, Ana Z.; Jabri, Salman; Belmontes, Brian; Moody, Gordon; Whittington, Doug; Huang, Xin; Caenepeel, Sean; Cardozo, Mario; Cheng, Alan C.; Chow, David; Dou, Hannah; Jones, Adrie; Kelly, Ron C.; Li, Yihong; Lizarzaburu, Mike; Lo, Mei-Chu; Mallari, Rommel; Meleza, Cesar; Rew, Yosup; Simonovich, Scott; Sun, Daqing; Turcotte, Simon; Yan, Xuelei; Wong, Simon G.; Yanez, Evelyn; Zancanella, Manuel; Houze, Jonathan; Medina, Julio C.; Hughes, Paul E.; Brown, Sean P. published an article about the compound: 4,4-Difluoropiperidine hydrochloride( cas:144230-52-4,SMILESS:FC1(F)CCNCC1.[H]Cl ).Electric Literature of C5H10ClF2N. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:144230-52-4) through the article.
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of tumors. Herein, we report our efforts toward the identification of a novel series of macrocyclic Mcl-1 inhibitors featuring an α-hydroxy phenylacetic acid pharmacophore or bioisostere. This work led to the discovery of 1(I), a potent Mcl-1 inhibitor (IC50 = 19 nM in an OPM-2 cell viability assay) with good pharmacokinetic properties and excellent in vivo efficacy in an OPM-2 multiple myeloma xenograft model.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem