Chaturvedula, Prasad V.; Pin, Sokhom; Tholady, George; Conway, Charlie M.; Macor, John E.; Dubowchik, Gene M. published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor》.Name: 4-Amino-1-benzylpiperidine-4-carbonitrile The author mentioned the following in the article:
We report the synthesis of rigid spirocyclic systems as conformationally constrained variants of the Ala-Phe-NH2 dipeptide amide C-terminus of the calcitonin gene-related peptide (CGRP). CGRP receptor antagonists containing these moieties displayed potent affinity, functional antagonism and excellent oxidative stability. Structure-activity relationship studies demonstrated the relative importance of hydrogen bond donor/acceptor functionalities and the preferred orientation of an aromatic ring. Antagonists showed potent and full reversal of CGRP-induced dilation of ex vivo human intracranial arteries.4-Amino-1-benzylpiperidine-4-carbonitrile(cas: 136624-42-5Name: 4-Amino-1-benzylpiperidine-4-carbonitrile) was used in this study.
4-Amino-1-benzylpiperidine-4-carbonitrile(cas: 136624-42-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Name: 4-Amino-1-benzylpiperidine-4-carbonitrile
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem