Effects-based monitoring of bioactive chemicals discharged to the Colorado river before and after a municipal wastewater treatment plant replacement was written by Cavallin, Jenna E.;Battaglin, William A.;Beihoffer, Jon;Blackwell, Brett R.;Bradley, Paul M.;Cole, Alexander R.;Ekman, Drew R.;Hofer, Rachel N.;Kinsey, Julie;Keteles, Kristen;Weissinger, Rebecca;Winkelman, Dana L.;Villeneuve, Daniel L.. And the article was included in Environmental Science & Technology in 2021.HPLC of Formula: 83799-24-0 The following contents are mentioned in the article:
Monitoring of the Colorado River near the Moab, Utah, wastewater treatment plant (WWTP) outflow has detected pharmaceuticals, hormones, and estrogen-receptor (ER)-, glucocorticoid receptor (GR)-, and peroxisome proliferator-activated receptor-gamma (PPARγ)-mediated biol. activities. The aim of the present multi-year study was to assess effects of a WWTP replacement on bioactive chem. (BC) concentrations Water samples were collected bimonthly, pre- and post-replacement, at 11 sites along the Colorado River upstream and downstream of the WWTP and analyzed for in vitro bioactivities (e.g., agonism of ER, GR, and PPARγ) and BC concentrations; fathead minnows were cage deployed pre- and post-replacement at sites with varying proximities to the WWTP. Before the WWTP replacement, in vitro ER (24 ng 17β-estradiol equivalent/L)-, GR (60 ng dexamethasone equivalent/L)-, and PPARγ-mediated activities were detected at the WWTP outflow but diminished downstream. In March 2018, the WWTP effluent was acutely toxic to the fish, likely due to elevated ammonia concentrations Following the WWTP replacement, ER, GR, and PPARγ bioactivities were reduced by approx. 60-79%, no toxicity was observed in caged fish, and there were marked decreases in concentrations of many BCs. Results suggest that replacement of the Moab WWTP achieved a significant reduction in BC concentrations to the Colorado River. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0HPLC of Formula: 83799-24-0).
2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.HPLC of Formula: 83799-24-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem