Category: piperidines

Electric Literature of 124172-53-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 124172-53-8, Name is N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide), SMILES is O=CN(CCCCCCN(C1CC(C)(C)NC(C)(C)C1)C=O)C2CC(C)(C)NC(C)(C)C2, belongs to piperidines compound. In a article, author is Al-Majid, Abdullah Mohammed, introduce new discover of the category.

X-ray Crystal Structure and Hirshfeld Analysis of Gem-Aminals-Based Morpholine, Pyrrolidine, and Piperidine Moieties

The gem-aminals of 1,2-dimorpholinoethane (1) and 1-morpholino-3-morpholinium bromide propane (2) were synthesized by reaction of two molar ratio of morpholine with the halogenating agents in the presence of basic condition (K2CO3) in acetone at room temperature (RT) overnight. The structures of the centro-symmetric compound 1 and the morpholinium salt derivative 2 were assigned unambiguous by single crystal X-ray diffraction analysis and compared with the 1,2-di(pyrrolidin-1-yl)ethane 3 and 1,2-di(piperidin-1-yl)ethane 4. The 1,2-dimorpholinoethane molecule has a center of symmetry at the midpoint of the C-C bond of the ethyl moiety leading to two equivalent halves. It crystallized in monoclinic crystal system and P2(1)/n space group, while the unit cell parameters are determined to be a = 6.0430(3), b = 8.0805(3), c = 11.1700(4) angstrom, and beta = 97.475(2)degrees with unit cell volume of 540.80(4) angstrom(3) and Z = 2 at 170(2) K. The less symmetric analogue 2 crystallized in the lower space group P2(1) with unit cell parameters of a = 6.37450(10), b = 11.1378(2), c = 9.6549(2) angstrom, and beta = 93.358(2)degrees, while the unit cell volume is 684.30(2)angstrom(3) at 120(2) K. Using Hirshfeld analysis, the molecules of 1 are mainly packed by weak N horizontal ellipsis H (4.2%), O horizontal ellipsis H (16.8%), and H horizontal ellipsis H (79.0%) interactions. In contrast, the molecules of 2 are packed by significantly short O horizontal ellipsis H (14.4%) and Br horizontal ellipsis H (11.6%) interactions in addition to the relatively long H horizontal ellipsis H (73.3%) interactions. DFT calculations predicted the molecular geometry of the studied compounds showing a good agreement with the experimental X-ray structures. Due to symmetry considerations, compounds 1, 3, and 4 are nonpolar with zero dipole moment, while the less symmetric molecule 2 has a dipole moment of 6.914 Debye. Their electronic aspects, such as natural population charges, HOMO, and LUMO energies as well as the corresponding reactivity descriptors, were also calculated and discussed.

Electric Literature of 124172-53-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 124172-53-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 79725-98-7, Name is (4-Oxo-5-(palmitoyloxy)-4H-pyran-2-yl)methyl palmitate, formurla is C38H66O6. In a document, author is Benadallah, Mohammed, introducing its new discovery. Recommanded Product: 79725-98-7.

Advances in Spirocyclic Hybrids: Chemistry and Medicinal Actions

The present review deals with the progress in medicinal chemistry of spirocyclic compounds, a wider class of natural and synthetic organic molecules, defined as a hybrid of two molecular entities covalently linked via a unique tetrahedral carbon. This spiro central carbon confers to the molecules a tridimensional structurally oriented framework, which is found in many medicinally relevant compounds, a well-known example is the antihypertensive spironolactone. Various bioactive natural products possess the privileged spiro linkage and different chemo-types thereof become synthetically accessible since the 20th century. Actually, there has been a growing interest in the synthesis of heterocyclic hybrids gathered via a spiro carbon. Most of these combinations are two moieties in one scaffold being able to interfere with biological systems through sequential mechanisms. Spirocyclic hybrids containing indole or oxindole units are compounds exhibiting higher interaction with biological receptors by protein inhibition or enzymatic pathways and their recognition as promising anticancer agents in targeted chemotherapy is foreseen. These specific, low-weight and non-complex spirocyclic hybrids are potent inhibitors of SIRT1, Mdm2-p53 and PLK4, showing affinity for anaplastic lymphoma kinase (ALK) receptor. They are also known as excellent DNA binders, acting on cellular division by arresting the cell cycle at different phases and inducing apoptotic cell death. A structural diversity of spirocyclic hybrids has proved neuroprotective effects, anti-HIV, antiviral and antibacterial activities. Hundred of papers are mentioned in this review underlying chemical issues and pharmacological potencies of spiro compounds, which render them impressive synthetic hits for innovative drug conception.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 14691-89-5, Name is 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, molecular formula is , belongs to piperidines compound. In a document, author is de Oliveira, Isadora M., Formula: C11H21N2O2*.

Copper(I)/succinic acid cooperatively catalyzed one-pot synthesis of organoselenium-propargylamines via A(3)-coupling

Selenium propargylamines were synthesized via an A(3)-coupling approach using piperidine, p-methoxybenzaldehyde, and trimethylsilyl selenium-acetylene, catalyzed by copper(i) chloride and succinic acid as an additive, in good to excellent yields. This method is advantageous in that desilylation of the trimethylsilyl selenium-acetylene occurs in situ. The reaction time was monitored by FTIR studies and a probable mechanism is described. Scale-up was also performed in satisfactory yield. These selenium propargylamines could be hydrohalogenated to synthesize halovinyl selenides. The stereochemistry was determined by treatment with n-butyllithium and the coupling constant (J) values in H-1 NMR spectra. The vinyl selenides were employed in Sonogashira cross-coupling reactions to produce the corresponding enynes, with yields ranging from moderate to good.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14691-89-5, in my other articles. Formula: C11H21N2O2*.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Kondej, Magda, once mentioned the application of 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO, molecular weight is 115.17, MDL number is MFCD00006500, category is piperidines. Now introduce a scientific discovery about this category, Quality Control of 1-Methylpiperidin-4-ol.

Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D-2 Receptor Ligand

Compound D2AAK1_3 was designed as a modification of the lead structure D2AAK1 (an in vivo active multi-target compound with nanomolar affinity to a number of aminergic GPCRs) and synthesized in the reaction of 5-ethoxyindole and 1-benzyl-4-piperidone. This compound has an affinity to the human dopamine D-2 receptor with K-i of 151 nM. The aim of these studies was the structural and thermal characterization of the compound D2AAK1_3. In particular; X-ray studies; molecular docking and molecular dynamics as well as thermal analysis were performed. The studied compound crystallizes in orthorhombic system; in chiral space group P2(1)2(1)2(1). The compound has a non-planar conformation. The studied compound was docked to the novel X-ray structure of the human dopamine D-2 receptor in the inactive state (PDB ID: 6CM4) and established the main contact between its protonatable nitrogen atom and Asp (3.32) of the receptor. The obtained binding pose was stable in molecular dynamics simulations. Thermal stability of the compound was investigated using the TG-DSC technique in the air atmosphere, while TG-FTIR analyses in air and nitrogen atmospheres were also performed. The studied compound is characterized by good thermal stability. The main volatile products of combustion are the following gases: CO2; H2O toluene and CO while in the case of pyrolysis process in the FTIR spectra; the characteristic bands of NH3; piperidine and indole are additionally observed.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, formurla is C14H18N4. In a document, author is Dooley, Charles J., III, introducing its new discovery. Recommanded Product: 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode’s Acylation Reagents

The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode’s chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary amines. The enantioselective acylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compounds. The limitations of the method were studied through computational analysis and experimental results. Piperidines with substituents at the 2-position did not behave well unless the axial conformer was energetically accessible, which is consistent with the transition state geometries proposed by Bode and Kozlowski. Control experiments were performed to investigate the cause of degrading selectivity under the CEC reaction conditions. The present study expands the scope of the CEC method for secondary amines and provides a better understanding of the reaction profile.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 120013-39-0, Name is 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride, SMILES is Cl.COC2=C(C=C1C(C(CC1=C2)CC3CCNCC3)=O)OC, in an article , author is Knight, Jonathon D., once mentioned of 120013-39-0, Formula: C17H24ClNO3.

Synthesis and radical copolymerization of novel propyl cyanoacrylate monomers

Novel phenyl-trisubstituted propyl 3-(R-phenyl)-2-cyanoacrylates (where R is 2,4,5-trimethyl, 2,4,6-trimethyl, 2,3-dimethyl-4-methoxy, 2,5-dimethyl-4-methoxy, 2,4-dimethoxy-3-methyl, 2,4-dimethoxy-6-methyl, 4-hydoxy-3,5-dimethyl, 2,3,4-trimethoxy, 2,4,5-trimethoxy, 2,4,6-trimethoxy, 3,4,5-trimethoxy) were prepared using piperidine-catalyzed condensation of substituted benzoic aldehydes and propyl ester of cyanoacetic acid with good yields (72-97 wt%). The ethenylbenzene copolymerization of cyanoacrylates (at 3/1 mol feed ratio) in solution with radical initiation at 70 degrees C resulted in formation of copolymers having M-W 3.9 to 27.8 kD and 8.4-25.8 mol% of cyanoacrylate. FTIR, H-1 and C-13 NMR were used to analyze the structure. Thermal behavior of the copolymers was analyzed by DSC, T-g (81-129 degrees C) and TGA. Decomposition of the copolymers in nitrogen occurred in two steps, first in the 200-500 degrees C range with residue (0.5-7.3 wt%)and then in the 500-800 degrees C range.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 120013-39-0, you can contact me at any time and look forward to more communication. Formula: C17H24ClNO3.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 2403-88-5, 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, SMILES is CC1(C)CC(O)CC(C)(C)N1, belongs to piperidines compound. In a document, author is Gomri, Marwen, introduce the new discover.

Adsorption characteristics of aromatic pollutants and their halogenated derivatives on bio-based poly (ether-pyridine)s

In this work, innovative poly(ether pyridine) polymers obtained from bio-based monomers and pentafluoropyridine derivatives were elaborated in order to adsorb aromatic pollutants and their halogenated derivatives. These polymers were obtained with satisfactory yields by polycondensation of four pyridinium monomers (respectively based on morpholine, piperazine, dimethylamine and phenol) with isosorbide or bisphenol A. The adsorption efficiency data demonstrate that the poly(etherpyridine) based on isosorbide and morpholine-based monomer (P2) is the more efficient sorbent toward aromatic pollutants and their derivatives. Four aromatic pollutants, p-hydroxybenzoic acid, toluic acid, deisopropylatrazine, and 2,4,6-trichlorophenol, were chosen as the adsorbate to investigate the adsorption efficiency, kinetics and isotherms of the poly(ether pyridine) P2. The results demonstrate that the pseudo-second order was the best to describe the adsorption of the four target pollutants by the efficient sorbent P2 with good correlation. The experimental data of the four target pollutants adsorption were analyzed by Langmuir and Freundlich isotherms. Polymer P2 shows very high affinity (low 1/n value) for p-hydroxybenzoic acid and for 2,4,6-trichlorophenol, compared to other adsorbents. Three consecutive adsorption/desorption cycles toward eight aromatic pollutants were obtained for the efficient sorbent P2.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2403-88-5 is helpful to your research. Product Details of 2403-88-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a document, author is Geary, Gemma C., introduce the new discover, Recommanded Product: 34737-89-8.

Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery

A spirocyclic, sp(3)-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lead Factory. (C) 2017 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 34737-89-8 is helpful to your research. Recommanded Product: 34737-89-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 108-26-9, Name is 3-Methyl-1H-pyrazol-5(4H)-one, molecular formula is , belongs to piperidines compound. In a document, author is Yamazaki, Shoko, Name: 3-Methyl-1H-pyrazol-5(4H)-one.

Synthesis of Piperidines via Intramolecular Hydride Transfer from alpha-Amino sp(3) Carbon Atoms to Ethenetricarboxylate-Derived Fragments and Further Cyclization

The cyclization of amides derived from ethenetricarboxylic acid bearing tert-amino groups has been examined. The amides were efficiently converted to piperidine derivatives (2-piperidones) upon heating in a polar solvent (e.g., DMSO or DMF) via intramolecular hydride transfer and subsequent ring closure. The reaction was less efficient in the presence of a Lewis acid. The reactivity varies depending on the alkyl substituents of tert-amino groups, probably due to steric effects. The hydride transfer/cyclization mechanism was investigated by DFT calculations. The reaction of the carboxylic acid and relatively bulky diamines such as diisopropyl-substituted diamine in the presence of amide condensation reagents at 60 degrees C gave the piperidine derivatives in a one-pot reaction. The reaction of the diisopropylamine substituted piperidine product with primary amines gave secondary amine-substituted piperidines.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108-26-9, in my other articles. Name: 3-Methyl-1H-pyrazol-5(4H)-one.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: N2,9-Diacetylguanine, 3056-33-5, Name is N2,9-Diacetylguanine, SMILES is CC(=O)NC1=NC2=C(N=CN2C(C)=O)C(=O)N1, belongs to piperidines compound. In a document, author is Masson, Guillaume, introduce the new discover.

Azetidiniums: Ring-Expansion to Pyrrolidines, Piperidines, Azepanes, and Azocanes

The 4-membered ring in bicyclic azetidiniums, e.g. 1-azabicyclo[2.n.0]alkanes (n= 1-4), can be efficiently transformed to larger rings. This minireview focuses on the ring-expansion of these azetidiniums to five- and eight-membered nitrogen containing heterocycles (pyrrolidines, piperidines, azepanes and azocanes). The ring-expansion is induced by nucleophiles which can be internal nucleophiles (leaving groups), or external nucleophiles.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3056-33-5. Recommanded Product: N2,9-Diacetylguanine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem