Category: piperidines

4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, molecular formula is C12H9N5O, belongs to piperidines compound, is a common compound. In a patnet, author is dos Santos, Nathalia M., once mentioned the new application about 4005-49-6, COA of Formula: C12H9N5O.

3-Hydroxy-piperidinyl-N-benzyl-acyl-arylhydrazone derivatives reduce neuropathic pain and increase thermal threshold mediated by opioid system

Here in, we report the preparation and evaluation of four 3-hydroxy-piperidine-N-benzyl-aryl-acylhydrazone derivatives (6a-d) for their potential antinociceptive activity. In the tail flick test, compounds 6a and 6d exhibited a significant increase in the latency time of the animals, in comparison to the control group. These two compounds also showed a significant increase in the nociceptive threshold from 1 to 6 h after treatment in the CCI neuropathic pain model. In both cases, the antinociceptive activity was blocked by naloxone, suggesting an opioid mechanism of action, but without sedative or motor coordination effects.

If you¡¯re interested in learning more about 4005-49-6. The above is the message from the blog manager. COA of Formula: C12H9N5O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 120-73-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 120-73-0, Name is Purine, SMILES is C12=NC=NC1=CNC=N2, belongs to piperidines compound. In a article, author is Zampieri, Daniele, introduce new discover of the category.

Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands

Among several potential applications, sigma receptor ligands can be used as antipsychotics, antiamnesics, and against other neurodegenerative disorders as well as neuroprotective agents. We present herein a new series of diazepane-containing derivatives as sigma R ligands obtained by a conformational expansion approach of our previously synthesized piperidine-based compounds. The best results were reached by benzofurane 2c, 3c and quinoline 2d, 3d-substituted diazepane derivatives, which showed the highest sigma R affinity. The cytotoxic activities of synthesized compounds were evaluated against two cancer cell lines, and the results indicated that none of the compounds induced significant toxicity in these cells. We also evaluated the antioxidant activity by radical scavenging capacity of our best compounds on ABTS and H2O2. The results obtained reveal that our new derivatives possess an excellent antioxidant profile and could be protective for the cells. Overall, the benzofurane derivative 2c due to its strong interaction with the active site of the receptor, as confirmed by molecular dynamic simulations, emerged as the optimum compound with high sigma 1R affinity, low cytotoxicity, and a potent antioxidant activity.

Application of 120-73-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 120-73-0.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 4418-26-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 4418-26-2, Name is Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide, SMILES is O=C(C=C(C)O1)[C-](C(C)=O)C1=O.[Na+], belongs to piperidines compound. In a article, author is Singh, Girija S., introduce new discover of the category.

Recent applications of aziridine ring expansion reactions in heterocyclic synthesis

The inherent reactivity of the aziridine ring due to ring-strain makes it valuable building blocks for the synthesis of other heterocyclic motifs of biological relevance. Of particular significance is the generation of azomethine ylides from them and cycloaddition of ylides with alkenes, alkynes, and heterocumulenes. The ring undergoes opening followed by cyclization with a variety of reagents either in the presence of a catalyst or without any catalyst. This review article discusses the recent applications of aziridines in syntheses of four- to seven-membered heterocycles of biological relevance such as azetidines, 2-azetidinones, pyrroles, imidazoles, oxazoles, thiazoles, piperidines, pyrazines, pyrimidines, benzoxazines, morpholines, azepanes, benzodiazepines, benzoxazepines, and benzothiazepines.

Reference of 4418-26-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4418-26-2.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hussein, A. M., once mentioned the application of 477600-74-1, Name is N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C13H19N5, molecular weight is 245.3235, MDL number is MFCD09878608, category is piperidines. Now introduce a scientific discovery about this category, Recommanded Product: N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.

beta-Oxo andides in Heterocyclic Synthesis: Novel Synthesis of Polyfunctionally Pyridines, Pyrimidines and Benzothiazole Derivatives

ACETOACETANILIDE derivative 1 was reacted with aromatic aldehydes 2 to yield the arylidine derivatives 3 and 6a, b. The IIantzsch amides 7a,b were prepared by the one-pot cyclization reaction of a mixture of 2 moles of 1, aqueous ammonia and aromatic aldehydes. Treatment of 1 with ethanol containing equivalent amount of piperidine or morpholine furnished the isolable products 8a and 8b. Compound 1 underwent interamolecular heterocyclization on boiling conc. sulfuric acid, afforded 9. Also, the reaction of compound 1 with hydroxylamine hydrochloride in ethanol and sodium acetate afforded the oxime derivative 10. Furthermore, reactions of compound 1 with o-aminothiophenol furnished 11. Reactions of 1 with arylidine derivatives give compounds 13 and 16a-d. Treatment of compound 16d with elemental sulfur afforded the thieno[3,4-c]pyridine derivative 18. Treatment of 16a with hydrazine hydrate in boiling ethanol afforded the pyrazolo[3,4-b]pyridine derivatives 19. Also, compound 16a was reacted with ethylchloroacetate giving 20. Compound 20 was cyclized into the corresponding thieno[2,3-b]-pyridine derivative 21 upon boiling with ethanol containing a few drops of sodium ethoxide solution. Furthermore, compound 1 readily reacted with cyanothioacetamide to yield compound 22. Fusion of compound 1 with malononitrile over melting point without solvent in presence of ammonium acetate or refluxing in ethanolic piperidine afforded the pyridone 23a. Also, the pyridone derivative 23b was obtained by reacting compound 1 with cyanoacetamide. The reaction of acetoacetanilide 1 with co-bromoacetophenones afforded 28a,b. Treatment of 1 with benzoyl and ethoxy carbonyl isothiocyanates afforded the pyrimidine derivatives 30a,b. The reaction of 1 with aminopyrazole gave the pyrazolopyrimidine 33. Coupling of 1 with diazonium salt of compounds 34a,b yielding 37a,b.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 477600-74-1, Recommanded Product: N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 4418-26-2, Name is Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide, molecular formula is C8H7NaO4. In an article, author is Sen, Abhijit,once mentioned of 4418-26-2, Recommanded Product: Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide.

Enantioselective Aza-Wacker-Type Cyclization Promoted by Pd-SPRIX Catalyst

An enantioselective aza-Wacker-type reaction was developed. When alkenyl sulfonamide substrates were treated with the Pd-SPRIX catalyst in the presence of oxone as an oxidant, the olefin was attacked intramolecularly by the nitrogen nucleophile to construct several heterocycles such as morpholines, piperazines, piperidines, and their benzo-fused derivatives in up to 88% yield with up to 80% ee.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry, like all the natural sciences, SDS of cas: 201341-05-1, begins with the direct observation of nature¡ª in this case, of matter.201341-05-1, Name is Tenofovir disoproxil, SMILES is O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O, belongs to piperidines compound. In a document, author is Zhong, Feng, introduce the new discover.

Catalytic Asymmetric Construction of Halogenated Stereogenic Carbon Centers by Direct Vinylogous Mannich-Type Reaction

A catalytic asymmetric vinylogous Mannich-type reaction of gamma-halo-alpha,beta-unsaturated N-acylpyrazoles and N-Boc-aldimines was disclosed, which afforded an array of halogenated (F-, Cl-, and Br-) allylic stereogenic carbon centers in high yields with good to high regio-, diastereo-, and enantioselectivities. The brominated product served as a suitable electrophile for common S(N)2 nucleophilic substitution and copper mediated S(N)2′ allylic alkylation with metal reagents. The utility of present methodology was demonstrated by the asymmetric synthesis of a common intermediate toward the synthesis of two chiral 2,3-disubstituted piperidine pharmaceuticals.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 201341-05-1. SDS of cas: 201341-05-1.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, SMILES is CC1(C)CC(O)CC(C)(C)N1, in an article , author is Downes, Thomas D., once mentioned of 2403-88-5, Name: 2,2,6,6-Tetramethyl-4-piperidinol.

Design and Synthesis of 56 Shape-Diverse 3D Fragments

Fragment-based drug discovery is now widely adopted for lead generation in the pharmaceutical industry. However, fragment screening collections are often predominantly populated with flat, 2D molecules. Herein, we describe a workflow for the design and synthesis of 56 3D disubstituted pyrrolidine and piperidine fragments that occupy under-represented areas of fragment space (as demonstrated by a principal moments of inertia (PMI) analysis). A key, and unique, underpinning design feature of this fragment collection is that assessment of fragment shape and conformational diversity (by considering conformations up to 1.5 kcal mol(-1)above the energy of the global minimum energy conformer) is carried out prior to synthesis and is also used to select targets for synthesis. The 3D fragments were designed to contain suitable synthetic handles for future fragment elaboration. Finally, by comparing our 3D fragments with six commercial libraries, it is clear that our collection has high three-dimensionality and shape diversity.

Interested yet? Read on for other articles about 2403-88-5, you can contact me at any time and look forward to more communication. Name: 2,2,6,6-Tetramethyl-4-piperidinol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 3056-33-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 3056-33-5, Name is N2,9-Diacetylguanine, SMILES is CC(=O)NC1=NC2=C(N=CN2C(C)=O)C(=O)N1, belongs to piperidines compound. In a article, author is Nowicka, Anna, introduce new discover of the category.

SYNTHESIS AND IN VITRO ANTIPROLIFERATIVE ACTIVITY OF NOVEL MANNICH BASES-2-ARYLIDENEAMINOBENZIMIDAZOLES DERIVATIVES

A new class of Mannich bases 5-16, 20-21, derivatives of 2-amino-1H-benzimidazole, were obtained in the condensation of Schiff bases 2-4 with selected secondary or primary amines: N-phcnylpiperazinc, 1-(2-pyridyl)piperazine, morpholine, piperidine, 2-chloroaniline, benzylamine and formaldehyde in ethanol. In reaction of 2-bromobenzylideneaminobenzimidazole with primary amines: o-chloroaniline and benzylamine carried out in room temperature 1-hydroxymethy1-2-(2-bromobenzylideneamino)benzimidazole (19) was obtained. In next step compound 19 with primary amines in boiling ethanol with catalytic amount of Triflate gave Mannich bases of various chemical structures. The structures 5-21 were confirmed by the results of elementary analysis and their IR, H-1, C-13-NMR spectra and mathematical optimalizations. All 20 compounds were screened against the cells of MV4-11 human leukemia. Selected 8 compounds with the highest activity (IC50 lower than 10 mu g/mL) were tested towards human breast (T47D), lung (A549) and colon (LoVo) cancer cells and normal mouse fibroblasts (BALB/3T3). Cisplatin was used as a control drug. Selected types of cancer are the examples of diseases frequently afflicted people worldwide.

Synthetic Route of 3056-33-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3056-33-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 4395-98-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 4395-98-6, Name is 4-Cyanopiperidine, SMILES is N#CC1CCNCC1, belongs to piperidines compound. In a article, author is Eom, So Young, introduce new discover of the category.

Accurate conformational stability and cationic structure of piperidine determined by conformer-specific VUV-MATI spectroscopy

Piperidine has received attention in pharmaceutical synthesis and biochemical degradation because of its conformational activity. We explored the conformational structures of piperidine in the neutral (S-0) and cationic (D-0) ground states by conformer-specific vacuum ultraviolet mass-analyzed threshold ionization (VUV-MATI) spectroscopy, which provides high-resolution vibrational spectra for the corresponding cationic conformer. To identify conformers corresponding to the obtained VUV-MATI spectra, equilibrium structures of piperidine conformers in the S-0 and D-0 states were determined at various density functional theory levels, and potential energy surfaces associated with the conformational changes were constructed. Notably, the chair form interconverting between the equatorial NH and the axial NH conformers (Chair-Eq and Chair-Ax) in piperidine lies on the global minimum of the S-0 state, but only the axial-like NH conformer (Chair-Ax-like) in chair form exists in the D-0 state. The vibrational assignment of the observed spectra was accomplished through Franck-Condon (FC) analysis for adiabatic transitions between two Chair-Eq and Chair-Ax conformers and a cationic Chair-Ax-like conformer. Rigorous FC analysis revealed the precise structure of a cationic Chair-Ax-like conformer induced by removal of an electron from the lone-pair sp(3) orbital of the nitrogen atom in piperidine. The adiabatic ionization energies of Chair-Eq and Chair-Ax conformers converting to a cationic state were determined to be 64 704 +/- 4 cm(-1) (8.0223 +/- 0.0005 eV) and 64 473 +/- 4 cm(-1) (7.9936 +/- 0.0005 eV), respectively. Consequently, the difference between their adiabatic ionization energies allowed the accurate determination of the conformational stability of Chair-Eq and Chair-Ax conformers in piperidine (231 +/- 4 cm(-1)).

Reference of 4395-98-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4395-98-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 2873-29-2, Name is (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, molecular formula is , belongs to piperidines compound. In a document, author is Yadav, Nagendra Nath, Category: piperidines.

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Bicyclic aziridinium ions were generated by the removal of an appropriate leaving group through internal nucleophilic attack by nitrogen atom in the aziridine ring. The utility of bicyclic aziridinium ions, specifically 1-azoniabicyclo[3.1.0]hexane and 1-azoniabicyclo[4.1.0]heptane tosylate highlighted in the aziridine ring openings by the nucleophile with the release of the ring strain to yield the corresponding ring-expanded azaheterocycles such as pyrrolidine, piperidine and azepane with diverse substituents on the ring in regio- and stereospecific manner. Herein, we report a simple and convenient method for the preparation of the stable 1-azabicyclo[4.1.0]heptane tosylate followed by selective ring opening via a nucleophilic attack either at the bridge or at the bridgehead carbon to yield piperidine and azepane rings, respectively. This synthetic strategy allowed us to prepare biologically active natural products containing piperidine and azepane motif including sedamine, allosedamine, fagomine and balanol in highly efficient manner.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2873-29-2, in my other articles. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem