Category: piperidines

Electric Literature of 13925-03-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 13925-03-6, Name is 2-Ethyl-6-methylpyrazine, SMILES is CC1=CN=CC(CC)=N1, belongs to piperidines compound. In a article, author is Akentieva, N. P., introduce new discover of the category.

Anticancer Activity of Spirocyclic Hydroxamic Acids (Derivatives of 1-Hydroxy-1,4,8-Triazaspiro[4,5]Decan-2-One), Histone Deacetylase Inhibitors

Ten racemic spirocyclic hydroxamic acids (CHA 1-10, 1-hydroxy-1,4,8-triazaspiro [4,5]decan-2-one derivatives) containing pharmacophore imidazolidine and piperidine fragments with various substituents were synthesized. It was shown that CHA (1-10) are inhibitors of the activity of the histone deacetylase enzyme in cultured breast cancer cells. The study of antitumor activity in vivo CHA (1-10) showed that in polychemotherapy with cisplatin and cyclophosphamide these compounds possess pronounced chemosensitizing antitumor activity and increase the life span of experimental animals. Thus, it is shown that spirocyclic hydroxamic acids possess therapeutic potential in polychemotherapy for the treatment of oncological diseases.

Electric Literature of 13925-03-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 13925-03-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 3056-33-5, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 3056-33-5, Name is N2,9-Diacetylguanine, SMILES is CC(=O)NC1=NC2=C(N=CN2C(C)=O)C(=O)N1, belongs to piperidines compound. In a article, author is Hussain, Javeena, introduce new discover of the category.

Synthesis and characterization of a new class of phenothiazine molecules with 10H-substituted morpholine & piperidine derivatives: A structural insight

A series of 10H-substituted phenothiazine-based molecules were prepared by the base-catalyzed reactions. The synthesized compounds are characterized by Mass spectroscopy, NMR, and SCXRD to examine the role of different functional groups involved in the intermolecular interactions and conformational geometries. The crystal packing of the compounds is governed by O-H center dot center dot center dot O, C-H center dot center dot center dot O, and pi-pi interactions. A complete understanding of the intermolecular interactions is studied employing the Hirshfeld analysis, 2D Fingerprint plot. Furthermore, the density functional theory (DFT/B3LYP) method at the 6-311++G(d,p) basis set was performed to support and compare experimental & theoretical geometrical parameters of phenothiazine derivatives. (C) 2020 Elsevier B.V. All rights reserved.

Application of 3056-33-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 3056-33-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 19916-73-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 19916-73-5, Name is 6-(Benzyloxy)-7H-purin-2-amine, SMILES is C3=NC1=C(C(=NC(=N1)N)OCC2=CC=CC=C2)[NH]3, belongs to piperidines compound. In a article, author is Waddell, Lachlan J. N., introduce new discover of the category.

Asperidine B: Total synthesis and structure correction

A synthesis of the proposed structure of asperidine B is reported, involving a tandem hydroformylation-condensation reaction, a diastereoselective dihydroxylation and the addition of an organozinc reagent to an iminium ion. As the spectroscopic data for the synthetic material is not in agreement with that of the natural product, the structure of asperidine B is reassigned as (+)-preussin. (C) 2020 Elsevier Ltd. All rights reserved.

Electric Literature of 19916-73-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 19916-73-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O. In an article, author is Olsson, Joel S.,once mentioned of 179474-79-4, Product Details of 179474-79-4.

Functionalizing Polystyrene with N-Alicyclic Piperidine-Based Cations via Friedel-Crafts Alkylation for Highly Alkali-Stable Anion-Exchange Membranes

Different anion-exchange membranes (AEMs) based on polystyrene (PS)-carrying benzyltrimethyl ammonium cations are currently being developed for use in alkaline fuel cells and water electrolyzers. However, the stability in relation to these state-of-the-art cations needs to be further improved. Here, we introduce highly alkali-stable mono- and spirocyclic piperidine-based cations onto PS by first performing a superacid-mediated Friedel-Crafts alkylation using 2-(piperidine-4-yl)propane-2-ol. This is followed by quaternization of the piperidine rings either using iodomethane to produce N,N-dimethyl piperidinium cations or by cyclo-quaternizations using 1,5-dibromopentane and 1,4-dibromobutane, respectively, to obtain N-spirocyclic quaternary ammonium cations. Thus, it is possible to functionalize up to 27% of the styrene units with piperidine rings and subsequently achieve complete quaternization. The synthetic approach ensures that all of the sensitive beta-hydrogens of the cations are present in ring structures to provide high stability. AEMs based on these polymers show high alkaline stability and less than 5% ionic loss was observed by H-1 NMR spectroscopy after 30 days in 2 M aq NaOH at 90 degrees C. AEMs functionalized with N,N-dimethyl piperidinium cations show higher stability than the ones carrying N-spirocyclic quaternary ammonium. Careful analysis of the latter revealed that the rings formed in the cyclo-quaternization are more prone to degrade via Hofmann elimination than the rings introduced in the Friedel-Crafts reaction. AEMs with an ion-exchange capacity of 1.5 mequiv g(-1) reach a hydroxide conductivity of 106 mS cm(-1) at 80 degrees C under fully hydrated conditions. The AEMs are further tuned and improved by blending with polybenzimidazole (PBI). For example, an AEM containing 2 wt % PBI shows reduced water uptake and much improved robustness during handling and reaches 71 mS cm(-1) at 80 degrees C. The study demonstrates that the critical alkaline stability of PS-containing AEMs can be significantly enhanced by replacing the benchmark benzyltrimethyl ammonium cations with N-alicyclic piperidine-based cations.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 401566-79-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Yamaguchi-Sasaki, Toru, introduce new discover of the category.

Design and Synthesis of 2-(1-Alkylaminoalkyl)pyrazolo[1,5-a]pyrimidines as New Respiratory Syncytial Virus Fusion Protein Inhibitors

Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections and a significant pathogen for both adults and children. Although two drugs have been approved for the treatment of RSV infections, the low therapeutic index of these drugs have led pharmaceutical companies to develop safe and effective small-molecule anti-RSV drugs. The pyrazolo[1,5-a]pyrimidine series of compounds containing a piperidine ring at the 2-position of the pyrazolo[1,5-a]pyrimidine scaffold are known as candidate RSV fusion (F) protein inhibitor drugs, such as presatovir and P3. The piperidine ring has been revealed to facilitate the formation of an appropriate dihedral angle between the pyrazolo[1,5-a]pyrimidine scaffold and the plane of the amide bond for exertion of anti-RSV activity. A molecular-dynamic study on newly designed compounds with an acyclic chain instead of the piperidine ring proposed and demonstrated a new series of pyrazolo[1,5-a]pyrimidine derivatives, such as 9c with a 1-methyaminopropyl moiety, showing similar dihedral angle distributions to those in presatovir. Compound 9c exhibited potent anti-RSV activity with an EC50 value of below 1 nM, which was similar to that of presatovir. A subsequent optimization study on the benzene ring of 9c led to the potent RSV F protein inhibitor 14f with an EC50 value of 0.15 nM. The possibility of improving the biological properties of anti-RSV agents by modification at the 7-position of pyrazolo[1,5-a]pyrimidine is also discussed.

Synthetic Route of 401566-79-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 401566-79-8 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 79725-98-7, Name is (4-Oxo-5-(palmitoyloxy)-4H-pyran-2-yl)methyl palmitate, SMILES is O1C(=CC(=O)C(=C1)C(=O)OCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC, in an article , author is Green, B. T., once mentioned of 79725-98-7, Computed Properties of C38H66O6.

Complete inhibition of fetal movement in the day 40 pregnant goat model by the piperidine alkaloid anabasine but not related alkaloids

Four chemically similar alkaloids, anabasine, anabaseine, epibatidine and dimethylphenylpiperazinium (DMPP), are potent nicotinic acetylcholine receptor agonists of fetal muscle nicotinic acetylcholine receptors in human TE-671 cells. Based on results with these cells, we hypothesized that the alkaloids would completely inhibit ultrasound-monitored fetal movement in a goat model. Different, single doses of anabasine, anabaseine, epibatidine, DMPP, or saline control were administered I.V. to pregnant goats on day 40 of gestation and the number of fetal movements per 5 min sample was measured by ultrasound at times 0, 0.5, 1, 2, 4 and 8 h. The differences among does in fetal movements were more consistent at dosing and following recovery for doses of anabasine above 0.125 mg/kg compared to the other compounds and dosages. Anabasine actions were dose-dependent with an IC50 value of similar to 0.1 mg/kg, and, at a dose of 0.8 mg/kg, completely inhibited fetal movement for 1.5 h after dosing. Anabaseine, epibatidine, and DMPP failed to completely inhibit fetal movement in day 40 pregnant goats at doses predicted to be effective. These results suggest that while experiments with TE-671 cells provide valuable information and predictions of the actions of plant alkaloids on fetal movement, in vivo experiments are still required in order to determine the ability of an alkaloid to inhibit fetal movement in livestock species. Moreover, other pharmacological properties such as receptor differences between mammalian species and differences in the pharmacokinetic properties of the alkaloids also are likely to weaken teratologic predictions based solely on the in vitro data. Published by Elsevier Ltd.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 79725-98-7, you can contact me at any time and look forward to more communication. Computed Properties of C38H66O6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4418-26-2, Name is Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide, molecular formula is C8H7NaO4. In an article, author is Astaneh, H. R. Haghjoo,once mentioned of 4418-26-2, SDS of cas: 4418-26-2.

Use of nanocrystalline ZnO as an efficient and reusable catalyst for a one-pot, three-component synthesis of 6-chloro- and 5,7-dichloro-4-hydroxy-3-[aryl (piperidin-1-yl)methyl]quinolin-2(1H)-ones in water

A one-pot, green, efficient and facile procedure was applied for the preparation of a series of 4-hydroxy-3-[aryl(piperidin-1-yl)methyl]quinolin-2(1H)-ones via the reaction of 6-chloro-4-hydroxyquinoline-2(1H)-one 1 and/or 5,7-dichloro-4-hydroxyquinoline-2(1H)-one 2, piperidine and aromatic aldehydes in water in the presence of nanocrystalline ZnO under reflux conditions. The desired products were obtained in satisfactory yields. The nanocrystalline ZnO can be separated and reused at least up to three times with almost the same catalytic activity.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 34737-89-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a article, author is Mu, Changhua, introduce new discover of the category.

Activation by Oxidation: Ferrocene-Functionalized Ru(II)-Arene Complexes with Anticancer, Antibacterial, and Antioxidant Properties

Organometallic Ru(II)-cymene complexes linked to ferrocene (Fc) via nitrogen heterocycles have been synthesized and studied as cytotoxic agents. These compounds are analogues of Ru(II)-arene piano-stool anticancer complexes such as RAPTA-C. The Ru center was coordinated by pyridine, imidazole, and piperidine with 0-, 1-, or 2-carbon bridges to Fc to give six bimetallic, dinuclear compounds, and the properties of these complexes were compared with their non-Fc-functionalized parent compounds. Crystal structures for five of the compounds, their Ru-cymene parent compounds, and an unusual trinuclear compound were determined. Cyclic voltammetry was used to determine the formal M-III/II potentials of each metal center of the Ru-cymene-Fc complexes, with distinct one-electron waves observed in each case. The Fc-functionalized complexes were found to exhibit good cytotoxicity against HT29 human colon adenocarcinoma cells, whereas the parent compounds were inactive. Similarly, antibacterial activity from the Ru-cymene-Fc compounds was observed against Bacillus subtilis, but not from the unfunctionalized complexes. In both cases, the IC50 values correlated quantitatively with the Fc(+/0) reduction potentials. This is consistent with more facile oxidation to give ferrocenium, and subsequent generation of toxic reactive oxygen species, leading to greater cytotoxicity. The antioxidant properties of the complexes were quantified by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. EC50 values indicate that linking of the Ru and Fc centers promotes antioxidant activity.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is an experimental science, Name: Piperidin-4-one hydrochloride, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 41979-39-9, Name is Piperidin-4-one hydrochloride, molecular formula is C5H10ClNO, belongs to piperidines compound. In a document, author is Hazelden, Ian R..

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates

Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6-exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 41979-39-9. Name: Piperidin-4-one hydrochloride.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Qi, Shunxin, once mentioned the application of 124172-53-8, Name is N,N’-(Hexane-1,6-diyl)bis(N-(2,2,6,6-tetramethylpiperidin-4-yl)formamide), molecular formula is C11H14N2O2, molecular weight is 450.7, MDL number is MFCD25292833, category is piperidines. Now introduce a scientific discovery about this category, Recommanded Product: 124172-53-8.

New insight into the thermal-oxidative stability of polyamide 6: A comparison investigation on the effect of hindered amine and CuI/KI

Polyamide 6 (PA6) and stabilized PA6 with two different thermal stabilizers, (ie, metal salts CuI/KI and hindered amine KYN818 [1,3-benzendicarboxamide,N,N’-bis(2,2,6,6-tetramethyl-4-piperidinyl)]) were separately prepared by melt blending and then aged for different time. The effects of aging temperature and aging time on crystallization behaviors of PA6 and stabilized PA6 were systematically investigated by differential scanning calorimetry and X-ray diffraction. The variations of melting temperature, crystallinity and 2 theta values suggest that aging under high temperature will accelerate the formation of crystals initially and then the degradation of molecular chains. The yellowness index and maximum decomposition temperature of stabilized PA6 are higher than that of PA6, which is dominated by different aging mechanisms and properties of stabilizers. In addition, the viscosity of all systems is increased at the preliminary stage, which is caused by the crosslinking network and the post-polycondensation. The results of dynamic mechanical analysis showed that the glass transition temperature (T-g) decreases because the degradation of molecular chains during the aging process. Moreover, the carbonyl index for stabilized PA6 is lower than PA6, indicating the degradation is hindered by stabilizers. A comparison of the stabilization performance between CuI/KI and KYN818 was investigated to differentiate the long-term stabilizing efficiency.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem