Category: piperidines

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Computed Properties of C8H7NaO44418-26-2, Name is Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide, SMILES is O=C(C=C(C)O1)[C-](C(C)=O)C1=O.[Na+], belongs to piperidines compound. In a article, author is Moreira Lacerda, Rosimeire Borges, introduce new discover of the category.

Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis

Leishmaniasis is one of the most important neglected tropical diseases (NTDs) that are especially common among low-income populations in developing regions of Africa, Asia, and the Americas. Many natural products, particularly alkaloids, have been reported to have inhibitory activity against arginase, the key enzyme in the pathology caused by Leishmania sp. In this way, piperidine alkaloids (-)-cassine (1), (-)-spectaline (2), (-)-3-O-acetylcassine (3), and (-)-3-O-acetylspectaline (4) were isolated from Senna spectabilis flowers. These compounds (1/2 and 3/4) initially present as homologous mixtures were separated by high performance liquid chromatography and evaluated against the promastigote phase of Leishmania amazonensis. In addition, molecular docking simulations were implemented in order to probe the binding modes of the ligands 1-4 to the amino acids in the active site of L. amazonensis arginase. Alkaloid 2 (IC50 15.81 mu g mL(-1)) was the most effective against L. amazonensis. Compounds 2 and 4, with larger side chain, were more effective against the parasite than compounds 1 and 3. The cell viability test on Vero cells revealed that compound 2 (CC50 66.67 mu g mL-1) was the most toxic. The acetyl group in the 3-O position of the parent structures reduced the leishmanicidal activity and the toxicity of the alkaloids. Further, molecular docking suggested that Asn143 is essential for arginase to interact with (-)-spectaline-derived compounds, which agreed with the IC50 measurements. Our findings revealed that S. spectabilis is an important source of piperidine alkaloids with leishmanicidal activity. Moreover, the natural compound 3 has been isolated for the first time. Experimental investigation combined with theoretical study advances knowledge about the enzyme binding site mode of interaction and contributes to the design of new bioactive drugs against Leishmania infection.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 4418-26-2. Computed Properties of C8H7NaO4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, SMILES is O=C(NC1=C2NC=NC2=NC=N1)C3=CC=CC=C3, belongs to piperidines compound. In a document, author is Muzaffar, Saima, introduce the new discover, Safety of N-(7H-Purin-6-yl)benzamide.

Evaluation of Ethylated Phenylcarbamoylazinane-1,2,4-Triazole Amides Derivatives as 15-Lipoxygenase Inhibitors Together with Cytotoxic, ADME and Molecular Modeling Studies

Searching the organic compound as anti-inflammatory agent is a fruitful effort to treat inflammatory disorders such as asthma, arthritis, psoriasis, and especially cancer. These disorders can be cured by lipoxygenase (LOX) inhibitors, which have the ability to stop the development and progression of inflammation. The present research described the synthesis of fifteen new N-alkyl/aralkyl/aryl derivatives (7 a-o) of 2-(4-ethyl-5-(1-phenylcarbamoyl)piperidine-4H-1,2,4-triazol-3-ylthio)acetamide by the continuous conversions of ethyl piperidine-4-carboxylate (a) into phenylcarbamoyl derivative (1) hydrazide (2), semicarbazide (3) and finally the N-ethylated 5-(1-phenylcarbamoyl)piperidine-1,2,4-triazole (4). The target molecules (7 a-o) were formed by the reaction of 4 with various electrophiles (6 a-o), in methanolic potassium hydroxide. These synthetic analogues were characterized by FTIR, H-1, C-13 NMR spectroscopy, EIMS, and HREIMS spectrometry. The compounds 7 a-o were screened for their inhibitory potential against 15-lipoxygenase. Compounds 7 b, 7 e, 7 c and 7 g displayed the potent inhibitory potential (IC50 17.52 +/- 0.67, 35.61 +/- 0.81, 36.24 +/- 0.83 & 36.52 +/- 0.58 mu M, respectively), whereas, moderate inhibition was shown by 7 h, 7 a, 7 d with IC50 values between 42.95 +/- 0.73 to 45.67 +/- 0.75 mu M, respectively. Some compounds exhibited drug-like characteristics due to their lower cytotoxic and good ADME profiles and supported by molecular modeling studies where one of the NH groups was found engaged through hydrogen bonding with Ala672. The carbonyl group amide and Asn554 were connected by a hydrogen bond, whereas the second NH group was also linked through hydrogen bonds with Gln363.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4005-49-6 is helpful to your research. Safety of N-(7H-Purin-6-yl)benzamide.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 5570-77-4, Name is 4-Chloro-1-methylpiperidine, SMILES is CN1CCC(CC1)Cl, in an article , author is Liu, Xiaojian, once mentioned of 5570-77-4, Quality Control of 4-Chloro-1-methylpiperidine.

Ligand-Controlled Regioselective Pd-Catalyzed Diamination of Alkenes

A ligand-controlled system has been disclosed for the regioselective palladium-catalyzed diamination of unactivated alkenes, which provides an easy access to a variety of aminofunctionalized piperidines and pyrrolidines. The steric hindrance of ligands controlled the regioselectivtities of products. 6-Endo diamination occurred with less sterically hindered quinox ligand to afford 3-aminopiperidines, while 5-exo diamination occurred with sterically bulky pyox ligand to give amino-substituted pyrrolidines.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 401566-79-8, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Lau, Justin Kai-Chi, introduce new discover of the category.

Collision-induced dissociation of protonated fentanyl: A DFT study

The fragmentation pathways leading to the major products resulting from collision-induced dissociation of protonated fentanyl are investigated. Starting from a protonated fentanyl in a twist conformation, transfer of the proton from the piperidine to the amide nitrogen allows the lone pair of the piperidine nitrogen to assist in displacement of the amide group and results in ring-opening of the piperidine to yield an ion with m/z 188 (C13H18N+). This is the fragmentation pathway with the lowest energy barrier; the barrier to the loss of the phenethyl group as a phenonium or 1-phenylethyl cation from the nitrogen in the piperidine ring is 64 kJ mol(-1) higher in energy. At even higher collision energies a bicyclic ion, also with nominal m/z 188 but with different elemental composition (C12H14NO+), is formed after sequential losses of ethene and phenethylamine from protonated fentanyl. Possible pathways to ring opening of the piperidine ring of N-protonated fentanyl include nucleophilic attack by the amide oxygen or the phenyl ring on the piperidine ring. The two m/z 188 ions give different dissociation products; minor products in the mass spectrum of protonated fentanyl at m/z 146, 134 and 132 are all generated from the dominant m/z 188 ion, C13H18N+, whereas only a product at m/z 132 is formed from the C12H14NO+ ion.

Related Products of 401566-79-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 401566-79-8 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 34737-89-8, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 34737-89-8, Name is 1-Benzyl-3-methylpiperidin-4-one, SMILES is O=C1C(C)CN(CC2=CC=CC=C2)CC1, belongs to piperidines compound. In a article, author is Dileep, K., V, introduce new discover of the category.

Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors

Alzheimer’s disease (AD), a common chronic neurodegenerative disease, has become a major public health concern. Despite years of research, therapeutics for AD are limited. Overexpression of secretory glutaminyl cyclase (sQC) in AD brain leads to the formation of a highly neurotoxic pyroglutamate variant of amyloid beta, pGluAp, which acts as a potential seed for the aggregation of full length A beta. Preventing the formation of pGlu-A beta through inhibition of sQC has become an attractive disease-modifying therapy in AD. In this current study, through a pharmacophore assisted high throughput virtual screening, we report a novel sQC inhibitor (Cpd-41) with a piperidine-4-carboxamide moiety (IC50 = 34 mu M). Systematic molecular docking, MD simulations and X-ray crystallographic analysis provided atomistic details of the binding of Cpd-41 in the active site of sQC. The unique mode of binding and moderate toxicity of Cpd-41 make this molecule an attractive candidate for designing high affinity sQC inhibitors. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 34737-89-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 34737-89-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , HPLC of Formula: C20H21ClN2, 38092-89-6, Name is 8-Chloroazatadine, molecular formula is C20H21ClN2, belongs to piperidines compound. In a document, author is Vinoth, Nangagoundan, introduce the new discover.

Expedient Synthesis and Antibacterial Activity of Tetrahydro-1 ‘ H-spiro[indoline-3,4 ‘-quinoline]-3 ‘-carbonitrile Derivatives Using Piperidine as Catalyst

A convenient synthesis of 2 ‘-amino-7 ‘,7 ‘-dimethyl-2,5 ‘-dioxo-1 ‘-(phenylamino)-5 ‘,6 ‘,7 ‘,8 ‘-tetrahydro-1 ‘ H-spiro[indoline-3,4 ‘-quinoline]-3 ‘-carbonitrile derivatives has been designed using different substituted isatins, various 5,5-dimethyl-3-(2-phenylhydrazinyl)cyclohex-2-enones (arylhydrazones of dimedone) and malononitrile in ethanol with piperidine as catalyst at room temperature. The structures of the synthesized compounds have been elucidated by various spectroscopic techniques. The selected compounds have also been evaluated for their antibacterial activities against human pathogenic bacteria.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 38092-89-6. HPLC of Formula: C20H21ClN2.

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Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 120-73-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 120-73-0, Name is Purine, SMILES is C12=NC=NC1=CNC=N2, belongs to piperidines compound. In a article, author is McGregor, C., introduce new discover of the category.

Formation Constants and Conformational Analysis of Carbamates in Aqueous Solutions of 2-Methylpiperidine and CO2 from 283 to 313 K by NMR Spectroscopy

Quantitative C-13 nuclear magnetic resonance (NMR) spectroscopy was used to investigate the speciation in (2-methylpiperidine + H2O + CO2) systems at 283.2-313.2 K. The carbamate of 2-methylpiperidine(2-methylpiperidine-N-carboxylate) was shown for the first time to be a stable species in aqueous solutions. The spectroscopic results were used to obtain temperature-dependant formation constants for the carbamate using a simplified model for the activity coefficients from which the standard molar enthalpy of reaction was estimated. The results were incorporated into a self-consistent chemical equilibrium model, which includes vapor-liquid equilibria and all aqueous species, including the formation of carbamate. The predominant conformation of the sterically hindered carbamate, which was determined using two-dimensional exchange spectroscopy NMR, has the methyl group in the axial orientation and is in agreement with the density functional theory quantum chemical calculations.

Related Products of 120-73-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 120-73-0 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 10310-21-1, Name is 2-Amino-6-chloropurine, molecular formula is C5H4ClN5, belongs to piperidines compound, is a common compound. In a patnet, author is Palinkas, Noemi, once mentioned the new application about 10310-21-1, Quality Control of 2-Amino-6-chloropurine.

Palladium-Catalyzed Synthesis of Amidines via tert-Butyl isocyanide Insertion

Para-substituted iodobenzenes were reacted withtent-butyl isocyanide and piperidine as nucleophiles in a the presence of palladium-diphosphine catalysts. Both single and double insertion of the isocyanide was observed and the corresponding amidines and ketimine-amidines were obtained in yields of practical interest. With the increase of the tert-butyl isocyanide/iodobenzene ratio, 100% chemoselectivity toward the ketimine-amidine was achieved. The formation of the products was rationalized on the basis of a catalytic cycle analogous to that of the aminocarbonylation reactions. Clear connection was found between the activity and the electronic structure of the proposed catalyst Pd(diphosphine) by computational studies, as the more negative partial charge on palladium resulted in higher conversion. Among five isocyanide substrates, only tert-butyl isocyanide was proved to be active.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 10310-21-1. The above is the message from the blog manager. Quality Control of 2-Amino-6-chloropurine.

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Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 188111-79-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 188111-79-7, Name is (R)-1-Boc-3-Aminopiperidine, SMILES is C(=O)(OC(C)(C)C)N1CCC[C@H](C1)N, belongs to piperidines compound. In a article, author is Van de Walle, Tim, introduce new discover of the category.

Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents

The parasitic disease malaria places almost half of the world’s population at risk of infection and is responsible for more than 400,000 deaths each year. The first-line treatment, artemisinin combination therapies (ACT) regimen, is under threat due to emerging resistance of Plasmodium falciparum strains in e.g. the Mekong delta. Therefore, the development of new antimalarial agents is crucial in order to circumvent the growing resistance. Chloroquine, the long-established antimalarial drug, still serves as model compound for the design of new quinoline analogues, resulting in numerous new active derivatives against chloroquine-resistant P. falciparum strains over the past twenty years. In this work, a set of functionalized quinoline analogues, decorated with a modified piperidine-containing side chain, was synthesized. Both amino- and (aminomethyl)quinolines were prepared, resulting in a total of 18 novel quinoline-piperidine conjugates representing four different chemical series. Evaluation of their in vitro antiplasmodium activity against a CQ-sensitive (NF54) and a CQ-resistant (K1) strain of P. falciparum unveiled highly potent activities in the nanomolar range against both strains for five 4-aminoquinoline derivatives. Moreover, no cytotoxicity was observed for all active compounds at the maximum concentration tested. These five new aminoquinoline hit structures are therefore of considerable value for antimalarial research and have the potency to be transformed into novel antimalarial agents upon further hit-to-lead optimization studies. (C) 2020 The Authors. Published by Elsevier Masson SAS.

Related Products of 188111-79-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 188111-79-7 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, formurla is C14H18N4. In a document, author is Liu, Yi-Wen, introducing its new discovery. Safety of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Asymmetric synthesis of (-)-sedacryptine through a diastereoselective Mannich reaction of N,O-acetals with ketones

An efficient diastereoselective approach to access the 3-hydroxy-2,6-disubstituted piperidine scaffold 1 has been developed through the Mannich process involving N,O-acetal (2S,3R)-6 and ketones in excellent yield with high diastereoselectivity (dr > 99 : 1). In addition, the utility of this convenient one-pot process is demonstrated by the asymmetric synthesis of (-)-sedacryptine 3.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem