Category: piperidines

In an article, author is Alsharif, Meshari A., once mentioned the application of 2873-29-2, Application In Synthesis of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, Name is (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, molecular formula is C12H16O7, molecular weight is 272.25, MDL number is MFCD00063253, category is piperidines. Now introduce a scientific discovery about this category.

One pot synthesis, physicochemical and photophysical investigation of biologically active pyridine-3-carboxylate (ECPC) as probe to determine CMC of surfactants in organized media

Ethyl 4 – (9-ethyl-9H-carbazol-3-yl) – 2 – methyl – 5- oxo – 4, 5 – dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate (ECPC) was prepared by one pot multi component reaction of 9-ethyl-9H-carbazole-3-carbaldehyde, indane-1,3-dione, ethyl acetoacetate and ammonium acetate in the presence few drops of piperidine. Structure of the title compound (ECPC) was confirmed by the spectroscopic techniques (FT-IR, H-1-NMR, C-13-NMR, EI-MS) and elemental analysis. Photophysical parameter of the ECPC such as transition dipole moment, extinction coefficient, stokes shift, oscillator strength, fluorescence quantum yield were calculated by using the different solvents (based on the polarity). The results of compound ECPC showed red shift in absorbance and emission spectrum with increase in the polarity of the solvents from n-heptane to DMSO. Emission spectrum of ECPC effected with anionic and cationic surfactant so ECPC can be used as probe to determine critical micelle concentrations (CMC) of anionic sodium dodecyl sulfate (SDS) and cationic cetyltrimethylammonium bromide (CTAB) surfactant. The in-vitro antibacterial activity of ECPC was examined by the disk diffusion and minimum inhibitory concentration (MIC) methods against two Gram-positive and two Gram-negative bacteria by using Tetracycline as reference drug.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 201341-05-1, 201341-05-1, Name is Tenofovir disoproxil, SMILES is O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O, belongs to piperidines compound. In a document, author is Islam, Mohammad Jahirul, introduce the new discover.

Sterically encumbered dianionic dicarboranyl pincer ligand (C5H3N)(C2B10H11)(2) and its CNC Nickel(II) complex

The novel 2,6-bis(carborane) pyridine (C5H3N)(C2B10H11)(2) ligand precursor containing two icosahedral carborane clusters attached to the pyridine ring was synthesized by the SNAr reaction between 2,6-difluoropyridine and lithiated ortho-carborane LiC2B10H11. Lithiation of the proligand at carbon atoms of carborane cages and the subsequent reaction with Ni(PPh3)(2)Cl-2 afforded the square-planar Ni(II) pincer complex {(C5H3N)(C2B10H10)(2)} Ni(CH3CN). X-ray single crystal diffraction revealed extreme steric hindrance around the metal center in the complex imposed by two carboranyl groups in the rigid pincertype framework, which was also manifested by the high value of the ligand buried volume % V-bur = 70.6%. The title pincer complex {(C5H3N)(C2B10H10)(2)} Ni(CH3CN) was found to be a competent catalyst for nucleophilic addition of piperidine to acetonitrile. (C) 2017 Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 201341-05-1. Recommanded Product: 201341-05-1.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Vengatesh, Gopal, once mentioned the application of 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is C30H56N2O4, molecular weight is 508.78, MDL number is MFCD00134706, category is piperidines. Now introduce a scientific discovery about this category, Product Details of 41556-26-7.

Ring opening of 2,6-diaryl-3,5-diphenyl piperidine-4-one by acetic acid: Structural studies and Hirshfeld surface analysis of (E)-4-aryl-1,3-diphenylbut-3-en-2-ones

Six alpha,beta-unsaturated carbonyl compounds have been obtained from 2,6-diaryl-3,5-diphenylpiperidine-4-one by the treatment with acetic acid. A plausible mechanism for the ring opening of 2,6-diaryl-3,5-diphenyl piperidin-4-ones is proposed. The resultant (E)-4-aryl-1,3-diphenylbut-3-en-2-ones have been characterized by H-1 and C-13 nuclear magnetic resonance (NMR) spectral studies. One of the compounds was completely characterized by 2D NMR techniques, and structure of the compound is further proved by single-crystal X-ray diffraction (XRD) analysis. The crystal structure, three-dimensional framework of crystal, and Hirshfeld surface analysis of two of the compounds have been discussed. In the crystals, molecules are mainly linked by C-H center dot center dot center dot O hydrogen bonding interactions, and this interaction forms an inversion dimer with R-2(1)(6) and R-2(1)(10) ring motifs in one of the compounds. Hirshfeld surface indicates the dominance of H center dot center dot center dot H contacts on the overall surface.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Mgbeahuruike, Eunice Ego, once mentioned the application of 188111-79-7, Recommanded Product: (R)-1-Boc-3-Aminopiperidine, Name is (R)-1-Boc-3-Aminopiperidine, molecular formula is C10H20N2O2, molecular weight is 200.28, MDL number is MFCD03094717, category is piperidines. Now introduce a scientific discovery about this category.

Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects

Piper guineense is a food and medicinal plant commonly used to treat infectious diseases in West-African traditional medicine. In a bid to identify new antibacterial compounds due to bacterial resistance to antibiotics, twelve extracts of P. guineense fruits and leaves, obtained by sequential extraction, as well as the piperine and piperlongumine commercial compounds were evaluated for antibacterial activity against human pathogenic bacteria. HPLC-DAD and UHPLC/Q-TOF MS analysis were conducted to characterize and identify the compounds present in the extracts with promising antibacterial activity. The extracts, with the exception of the hot water decoctions and macerations, contained piperamide alkaloids as their main constituents. Piperine, dihydropiperine, piperylin, dihydropiperylin or piperlonguminine, dihydropiperlonguminine, wisanine, dihydrowisanine and derivatives of piperine and piperidine were identified in a hexane extract of the leaf. In addition, some new piperamide alkaloids were identified, such as a piperine and a piperidine alkaloid derivative and two unknown piperamide alkaloids. To the best of our knowledge, there are no piperamides reported in the literature with similar UV absorption maxima and masses. A piperamide alkaloid-rich hexane leaf extract recorded the lowest MIC of 19 mu g/mL against Sarcina sp. and gave promising growth inhibitory effects against S. aureus and E. aerogenes as well, inhibiting the growth of both bacteria with a MIC of 78 mu g/mL. Moreover, this is the first report of the antibacterial activity of P. guineense extracts against Sarcina sp. and E. aerogenes. Marked growth inhibition was also obtained for chloroform extracts of the leaves and fruits against P. aeruginosa with a MIC value of 78 mu g/mL. Piperine and piperlongumine were active against E. aerogenes, S. aureus, E. coli, S. enterica, P. mirabilis and B. cereus with MIC values ranging from 39-1250 mu g/mL. Notably, the water extracts, which were almost devoid of piperamide alkaloids, were not active against the bacterial strains. Our results demonstrate that P. guineense contains antibacterial alkaloids that could be relevant for the discovery of new natural antibiotics.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, molecular formula is C13H11N3O5, belongs to piperidines compound, is a common compound. In a patnet, author is Lo, Rabindranath, once mentioned the new application about 827026-45-9, Safety of 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione.

Structure-directed formation of the dative/covalent bonds in complexes with C70MIDLINE HORIZONTAL ELLIPSISpiperidine

The combined experimental-computational study has been performed to investigate the complexes formed between C-70 carbon allotrope and piperidine. The results of FT-IR, H-NMR, and C-NMR measurements, together with the calculations based on the DFT approach and molecular dynamics simulations, prove the existence of dative/covalent bonding in C70MIDLINE HORIZONTAL ELLIPSISpiperidine complexes. The dative bond forms not only at the region of five- and six-membered rings, observed previously with C-60, but also at the region formed of six-membered rings. The structure, i.e., nonplanarity, explains the observed dative bond formation. New findings on the character of interaction of secondary amines with C-70 bring new aspects for the rational design of modified fullerenes and their applications in electrocatalysis, spintronics, and energy storage.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 388077-74-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a article, author is Bari, Ahmed, introduce new discover of the category.

The crystal structure of ethyl-1-(N-(adamantan-1-yl)-carbamothioyl)piperidine-4-carboxylate, C19H30N2O2S

C19H30N2O2S, monoclinic, P2(1)/n (no. 14), a = 6.4977(5) angstrom, b = 28.728(2) angstrom, c = 10.1806(8) angstrom, beta = 101.549(3)degrees, V = 1861.9(2) angstrom(3), Z = 4, R-gt(F) = 0.0460, WRref(F-2) = 0.1213, T = 296 K.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 106-52-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 106-52-5, Name is 1-Methylpiperidin-4-ol, SMILES is OC1CCN(C)CC1, belongs to piperidines compound. In a article, author is Liu, Juan, introduce new discover of the category.

Molecular insights into the hydrodenitrogenation mechanism of pyridine over Pt/gamma-Al2O3 catalysts

The hydrodenitrogenation of nitrogen-containing heterocycles over noble metals has fundamental importance for energy and environmental science. To develop more efficient catalyst, mechanistic investigation has been conducted with a method combining in situ Fourier transformation infrared experiments and density functional theory calculations in this work. The in situ experiments indicate flatly adsorbed pyridine molecules convert to pyridinium and alpha-pyridyl species at higher temperature on metallic Pt of Pt/gamma-Al2O3 catalysts. Pyridine hydrogenation distinctly takes place at 150 degrees C with the appearance of methylene stretching vibrations, and a stepwise mechanism is identified as the temperature further increases. The adsorption, hydrogenation and hydrogenolysis of pyridine on Pt are studied in detail by theoretical calculations. In line with these findings, the geometry optimization confirms pyridine preferentially adsorbs on Pt(111) and Pt(211) both in a parallel configuration. Based on the Langmuir-Hinshelwood mechanism, the results show successive hydrogenation markedly lowers the energy barrier for subsequent hydrogenolysis. The C-N bond cleavage occurs via nucleophilic attack of pentahydropyridine, rather than piperidine, which determines the reaction products, including piperidine, n-pentylamine and n-pentane. The comparative study reveals both hydrogenation and hydrogenolysis are kinetically and thermodynamically more competitive on Pt(211) than Pt(111). Especially for hydrogenolysis, the coordinatively unsaturated Pt step atoms play an essential role in C-N bond cleavage. Thus, hydrogenolysis is more geometric-dependent than hydrogenation. This provides instructive information for the design of catalysts with adjustable product selectivity.

Synthetic Route of 106-52-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 106-52-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 4418-26-2, Name is Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide. In a document, author is Shadrikova, Vera A., introducing its new discovery. Quality Control of Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide.

Transformations of 1-[2-(Adamantan-1-Yl)-2-Hydroxyethyl]-1,2,3,6-Tetrahydropyridines by the Action of Trifluoromethanesulfonic Acid

1-[2-(Adamantan-1-yl)-2-hydroxyethyl]-1,2,3,6-tetrahydropyridines were obtained by reduction of 1-[(adamantan-1-yl)-2-oxoethyl]-pyridinium bromides. By the action of trifluoromethanesulfonic acid, they undergo carbocationic intramolecular cyclization accompanied by the Wagner-Meerwein rearrangement with the formation of substituted 1-azabicyclo[3.3.1]non-3-enes annulated with the homoadamantane framework. The structure of the obtained compounds was confirmed by spectral methods and X-ray structural analysis.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 827026-45-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, SMILES is [O-][N+](=O)C1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1, belongs to piperidines compound. In a article, author is Prasanthi, Gummalla, introduce new discover of the category.

Synthesis, evaluation, and molecular properties prediction of substituted cinnamoylpiperazine derivatives as potential antinociceptive and anticonvulsive agents

A series of novel cinnamoylpiperazine derivatives (5a-5l) were synthesized as potential antinociceptive, and anticonvulsive agents. Various heterocyclic systems like piperidine, morpholine, piperazine, and N-arylpiperazine were combined with cinnamoyl or methylenedioxy cinnamoyl moieties to obtain a series of constrained analogs of cinnamides. Of these, compound 5e possessing 4-fluorophenyl substitution on the piperazine ring exhibited good antinociceptive activity in capsaicin and formalin-induced nociception methods, and also significant anticonvulsant activity in pentylenetetrazole and maximal electroshock-induced seizure methods. Further, all the derivatives were studied for molecular and preadmet properties. The activities of compound 5e were supported by molecular and preadmet properties for its in silico oral bioavailability and drug-likeness.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Quality Control of (R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol, 14047-28-0, Name is (R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol, molecular formula is C8H11N5O, belongs to piperidines compound. In a document, author is Simonetti, Sebastian O., introduce the new discover.

Theoretical Study of the Borono-Mannich Reaction with Pinacol Allenylboronate

A density functional theory study of the mechanism of the Borono-Mannich reaction using benzylamine and piperidine as representative examples of primary and secondary amines with pinacol allenylboronate is presented. The study shows that both reactions progress through coordination between the boron and the phenolic oxygen. Ring size strain and hydrogen bond activation appear to determine the observed divergent regioselectivity. In the case of benzylamine, the eight-membered ring transition structure that leads to the propargylamine exhibits a hydrogen bond between the hydrogen attached to the nitrogen and the phenolic oxygen (gamma-attack), whereas for piperidine a hydrogen bond between the hydrogen on the imine carbon and one of the oxygens of the pinacol group was observed in the six-membered ring transition structure toward the allenylamine (alpha-attack).

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem