Category: piperidines

Let¡¯s face it, organic chemistry can seem difficult to learn, Product Details of 38092-89-6, Especially from a beginner¡¯s point of view. Like 38092-89-6, Name is 8-Chloroazatadine, molecular formula is piperidines, belongs to piperidines compound. In a document, author is Yuan, Yuan, introducing its new discovery.

Carnitine, A New Precursor in the Formation of the Plant Growth Regulator Mepiquat

Carnitine is demonstrated as an effective methyl donor in the formation of the plant growth regulator N,N-dimethylpiperidinium (mepiquat), encompassing either N-methylation/decarboxylation of pipecolic acid, or Maillard pathways followed by transmethylation reactions. The formation of mepiquat and the intermediate compounds was monitored (180-300 degrees C, up to 180 min) using HPLC-MS/MS in different binary or ternary model systems composed of (i) lysine/fructose/carnitine, (ii) lysine/glucose/carnitine, or (iii) pipecolic acid (PipAc)/carnitine. The highest yield of mepiquat was 2.4% after 120 min incubation at 290 degrees C (PipAc/carnitine model system). The highest yield was recorded in fructose and glucose (Maillard) systems after 180 min at 230 degrees C. The full -scan mode was used to monitor the formation of the corresponding intermediates (piperidine and N-methylpiperidine, the demethylated intermediates of carnitine). The new pathways of mepiquat formation indicate that the occurrence of low levels of this thermally induced compound is potentially more widespread in some selected cooked foodstuffs. For the first time, mepiquat was detected in oven-cooked beef, reaching up to 82.5 mu g/kg. These amounts are not expected to significantly contribute to the overall exposure via different foodstuffs, as reported in previous studies.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Jin, Jian, once mentioned the application of 201341-05-1, Name is Tenofovir disoproxil, molecular formula is C19H30N5O10P, molecular weight is 519.44, MDL number is MFCD00952920, category is piperidines. Now introduce a scientific discovery about this category, Name: Tenofovir disoproxil.

Isoquinolinone derivatives as potent CNS multi-receptor D-2/5-HT1A/5HT(2A)/5-HT6/5-HT7 agents: Synthesis and pharmacological evaluation

In this study, a series of novel Isoquinolinone derivatives were synthesized as potential multi-target antipsychotics. Among these, compound 13 showed high affinity for dopamine D-2 and serotonin 5-HT1A, 5-HT2A, 5-HT6, and 5-HT7 receptors, showed low affinity for off-target receptors (5-HT2C, H-1, and alpha(1)), and negligible effects on ether-a-gogo-related gene (hERG; i.e., reduced QT interval prolongation). An animal behavioral study revealed that compound 13 reversed APO-induced hyperlocomotion, MK-801-induced hyperactivity, and DOI-induced head twitch. Moreover, compound 13 exhibited a high threshold for acute toxicity, a lack of tendency to induce catalepsy, and did not cause prolactin secretion or weight gain when compared to risperidone. Furthermore, in the forced swim test, tail suspension test, and novel object recognition test, treatment with compound 13 resulted in improvements in depression and cognitive impairment. In addition, compound 13 had a favorable pharmacokinetic profile in rats. Thus, the antipsychotic drug-like effects of compound 13 indicate that it may be useful for developing a novel class of drugs for the treatment of schizophrenia. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 4418-26-2, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 4418-26-2, Name is Sodium 3-acetyl-6-methyl-2,4-dioxo-3,4-dihydro-2H-pyran-3-ide, SMILES is O=C(C=C(C)O1)[C-](C(C)=O)C1=O.[Na+], belongs to piperidines compound. In a article, author is Wang, Tao, introduce new discover of the category.

Use of Lipase Catalytic Resolution in the Preparation of Ethyl (2S,5R)-5-((Benzyloxy)amino)piperidine-2-carboxylate, a Key Intermediate of the beta-Lactamase Inhibitor Avibactam

Here we describe an efficient and cost-effective chemoenzymatic synthesis of the beta-lactamase inhibitor avibactam starting from commercially available ethyl 5-hydroxypicolinate hydrochloride. Avibactam was synthesized in 10 steps with an overall yield of 23.9%. The synthetic route features a novel lipase-catalyzed resolution step during the preparation of (2S,5S)ethyl 5-hydroxypiperidine-2-carboxylate, a valuable precursor of the key intermediate ethyl (2S,SR)-5-((benzyloxy)amino)piperidine-2-carboxylate. Our synthetic route was used to produce 400 g of avibactam sodium salt.

Reference of 4418-26-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 4418-26-2 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, belongs to piperidines compound. In a document, author is Ding, Luoyi, introduce the new discover, Formula: C11H19NO4.

Selective synthesis of epichlorohydrin via liquid-phase allyl chloride epoxidation over a modified Ti-MWW zeolite in a continuous slurry bed reactor

The epoxidation of allyl chloride (ALC) to epichlorohydrin (ECH) with H2O2 using a piperidine (PI)-modified Ti-MWW catalyst (Ti-MWW-PI) in a continuous slurry reactor was investigated to develop an efficient reaction system for the corresponding industrial process. The reaction parameters, including solvent, reaction temperature, t-butanol/ALC mass ratio, ALC/H2O2 molar ratio, weight hourly space velocity of H2O2, and the addition amount of ammonia, were studied in detail to pursue high H2O2 conversion and ECH selectivity. A long catalytic lifetime of 244 h was achieved at high H2O2 conversion (>97.0%) and ECH selectivity (>99.8%) under optimized reaction conditions. The crystallinity was well maintained for the deactivated Ti-MWW-PI catalyst, which was regenerated by a combination of calcination and piperidine treatment.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 88495-54-9 is helpful to your research. Formula: C11H19NO4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 4395-98-6, Name is 4-Cyanopiperidine, SMILES is N#CC1CCNCC1, in an article , author is Palchykov, Vitalii A., once mentioned of 4395-98-6, HPLC of Formula: C6H10N2.

Synthesis of new azapolycyclic scaffolds via the domino aminolysis of dicyclopentadiene diepoxide in water

A convenient method is reported for the multigram scale synthesis of compounds containing the novel octahydro-1H-2,5-epimino-4,7-methanoindene azapolycyclic system in good yields. This method involves the domino aminolysis of readily available dicyclopentadiene diepoxide in water at 165 degrees C. 2D NMR and XRD spectra of the products were studied in detail. (C) 2020 Elsevier Ltd. All rights reserved.

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Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 14691-89-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 14691-89-5, Name is 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, SMILES is CC1(C)CC(NC(C)=O)CC(C)(C)N1[O], belongs to piperidines compound. In a article, author is Hussein, Weiam, introduce new discover of the category.

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the weakening of the cholinergic system in the brain. Cholinesterase (ChE) inhibitors are recognized as one of the choices in the treatment of AD. The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were approved as a therapeutic strategy to reduce the symptoms of AD and prevent its progression. The capacity of BChE is not completely known yet; rather, it is accepted to assume a part in a few disorders such as AD. Thus, BChE inhibitors may have a greater role for the treatment of AD in the future. In the present study, 2-(9-acridinylamino)-2oxoethyl piperazine/piperidine/morpholinecarbodithioate derivatives were synthesized in order to investigate anticholinesterase activity. Eight derivatives demonstrated a specific and promising action against BChE. Furthermore, compound 4n showed inhibitory activity against both enzymes. It was found that the active compounds were well tolerated in the cytotoxicity test. Possible interactions between the lead compound, 4n, and the BChE enzyme were determined through a docking study. The findings obtained within this paper will contribute to the development of new and effective synthetic anti-Alzheimer compounds, and will ideally encourage future screening against AD.

Electric Literature of 14691-89-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 14691-89-5.

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Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 105812-81-5, Name is (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine, molecular formula is , belongs to piperidines compound. In a document, author is Marcote, David C., COA of Formula: C13H18FNO.

Gold(I)-Catalyzed Enantioselective Annulations between Allenes and Alkene-Tethered Oxime Ethers: A Straight Entry to Highly Substituted Piperidines and aza-Bridged Medium-Sized Carbocycles

Piperidine scaffolds are present in a wide range of bioactive natural products and are therefore considered as highly valuable, privileged synthetic targets. In this manuscript, we describe a gold-catalyzed annulation strategy that allows a straightforward assembly of piperidines and piperidine-containing aza-bridged products from readily available alkene-tethered oxime ethers (or esters) and N-allenamides. Importantly, we demonstrate the advantages of using oxime derivatives over imines, something pertinent to the whole area of gold catalysis, and provide relevant mechanistic experiments that shed light into the factors affecting the annulation processes. Moreover, we also describe preliminary experiments demonstrating the viability of enantioselective versions of the above reactions.

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Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Harifi-Mood, Ali Reza, once mentioned the application of 119515-38-7, Name: sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate, Name is sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate, molecular formula is C12H23NO3, molecular weight is 229.3159, MDL number is MFCD01756488, category is piperidines. Now introduce a scientific discovery about this category.

Dimethyl sulfoxide/deep eutectic solvents mixtures as media in the reaction of 1-fluoro-2,4-dinitrobenzene with piperidine: A solvent effect study

Aromatic nucleophilic substitution reaction of 1-fluoro-2,4-dinitrobenzene with piperidine was kinetically investigated in ethylene glycol-choline chloride and glycerol-choline chloride as 2 deep eutectic solvents (DESs) mixed with dimethyl sulfoxide, in whole mole fractions, at room temperature. The investigation of the reaction in different concentrations of the piperidine shows that the reaction follows the base-catalyzed mechanism. The measured rate coefficients of the reaction demonstrated a sharp decreasing in all mixtures with the increasing mole fraction of DESs. Linear free energy relationship investigations confirm that hydrogen bond donor ability in addition to polarity-polarizability of the media has a major effect on the reaction rate. The decrease in the rate coefficient is attributed to not only hydrogen-bonding donor interactions of the media with piperidine as both reactant and catalyst but also the preferential solvation of reactants by DES compared with the intermediate of the reaction.

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Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Vengatesh, G., once mentioned the application of 41979-39-9, Name is Piperidin-4-one hydrochloride, molecular formula is C5H10ClNO, molecular weight is 135.592, MDL number is MFCD00041019, category is piperidines. Now introduce a scientific discovery about this category, Formula: C5H10ClNO.

Experimental and theoretical evaluation of new piperidine and oxaquinuclidine core containing derivatives as an efficient corrosion inhibitor for copper in nitric acid medium

The inhibition efficiency of copper corrosion in 1 M HNO(3)by five piperidine and oxaquinuclidine core containing compounds namely 2,4,6,11-tetraphenyl-9-oxa-1,5-diazatricyclo [5.3.1.0(3.8)] undecane (OX1), 2,4,6,11-tetraaryl (4-methoxyphenyl)-9-oxa-1,5-diazatricyclo [5.3.1.0(3.8)] undecane (OX2), 2,4,6,11-tetraaryl (4-chlorophenyl)-9-oxa-1,5-diazatricyclo [5.3.1.0(3.8)] undecane (OX3), 2,4,6,11-tetraaryl-p-tolyl-9-oxa-1,5-diazatricyclo [5.3.1.0(3.8)] undecane (OX4), and 2,4,6,11-tetraaryl (4-fluorophenyl)-9-oxa-1,5-diazatricyclo [5.3.1.0(3.8)] undecane (OX5) has been investigated using gravimetric method, electrochemical studies, FT-IR, scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), DFT and Monte Carlo simulation techniques. Inhibitors are chosen based on electron donating and accepting ability to the metal surface. These compounds differentiated in phenyl ring containing electron withdrawing (Cl, F) and electron releasing (OCH3, CH3) substituents. Experimental and computational studies showed that methoxy (OCH3) substituent exhibit more efficiency compared to other compounds and it is due to more electron donating nature of the OCH(3)group. The adsorption of the inhibitors on copper surface obeyed Langmuir adsorption isotherm. Polarization results show that OXs are acting as a mixed type of inhibitors. In the surface characterization studies, change in frequency (FT-IR), change in surface roughness (SEM) and appearance of additional element peaks (EDX) before and after film formation confirmed the protective layer formation. Quantum chemical parameters and Monte Carlo simulation studies further evidenced by the inhibitor adsorption of the copper surface.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 88495-54-9, Name is (S)-1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid, SMILES is O=C([C@@H]1CN(C(OC(C)(C)C)=O)CCC1)O, belongs to piperidines compound. In a document, author is Rufino, Virginia C., introduce the new discover, Product Details of 88495-54-9.

Free energy profile and microkinetic modeling of base-catalyzed conjugate addition reaction of nitroalkanes to alpha,beta-unsaturated ketones in polar and apolar solvents

Michael reactions involving nitroalkanes and enones are important carbon-carbon bond formation reactions. These reactions are base-catalyzed, and during the past 15 years, the asymmetric version using bifunctional amino-thiourea organocatalyst has been developed. In this work, the reaction of nitromethane and 4-phenyl-3-buten-2-one, catalyzed by the methoxide ion and piperidine as bases, was investigated by theoretical calculations. We obtained the theoretical free energy profile and did a microkinetic analysis of the catalytic cycle. The direct reaction of the CH2NO2 (-) ion and the enone is very favorable, with a free energy of activation of 21.1 kcal mol(-1) in methanol solvent. However, the generated MS2 product works like an inhibitor of the catalysis, and the effective barrier in the catalytic cycle becomes 25.5 kcal mol(-1), leading to slow kinetics at room temperature. In the case of the reaction in apolar solvent (toluene), we found a pathway involving isomerization from the CH3NO2 reactant to the CH2NO2H species, and the latter makes a nucleophilic attack on the enone. Piperidine works like a bifunctional catalyst. In this case, the barrier is very high (32.5 kcal mol(-1)), indicating the importance of the polar environment to accelerate the reaction in the catalytic cycle.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 88495-54-9 is helpful to your research. Product Details of 88495-54-9.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem