Category: piperidines

Synthesis of Chiral Acyclic Nucleosides by Sharpless Asymmetric Dihydroxylation: Access to Cidofovir and Buciclovir was written by Qin, Tao;Li, Jian-Ping;Xie, Ming-Sheng;Qu, Gui-Rong;Guo, Hai-Ming. And the article was included in Journal of Organic Chemistry in 2018.Reference of 1928-81-0 This article mentions the following:

An efficient method to construct chiral acyclic nucleosides via Sharpless asym. dihydroxylation of N-allylpyrimidines or N-alkenylpurines is reported. A range of chiral acyclic nucleosides with two adjacent hydroxyl groups present on the side chains could be produced in good yields (up to 97% yield) and excellent enantioselectivities (90-99% ee). The synthetic utility of the reaction was demonstrated by the catalytic asym. synthesis of (S)-Cidofovir and (R)-Buciclovir. In the experiment, the researchers used many compounds, for example, 6-(Piperidin-1-yl)-9H-purine (cas: 1928-81-0Reference of 1928-81-0).

6-(Piperidin-1-yl)-9H-purine (cas: 1928-81-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Reference of 1928-81-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

UV-radiation curing of acrylate/epoxide systems was written by Decker, C.;Nguyen Thi Viet, T.;Decker, D.;Weber-Koehl, E.. And the article was included in Polymer in 2001.Synthetic Route of C30H56N2O4 This article mentions the following:

Interpenetrating polymer networks (IPNs) have been synthesized by light-induced crosslinking polymerization of a mixture of acrylate and epoxide monomers. The consumption of each monomer upon UV-irradiation in the presence of radical and cationic-type photoinitiators was monitored in situ by real-time IR spectroscopy. The acrylate monomer was shown to polymerize faster and more extensively than the epoxy monomer, which was further consumed upon storage of the sample in the dark, due to the living character of cationic polymerization Curing experiments carried out in the presence of air and under air diffusion-free conditions indicate that the radical polymerization of the acrylate monomer is hardly affected by the oxygen inhibition effect, while the cationic polymerization of the epoxy monomer is enhanced by the atm. humidity. The addition of a photosensitizer, like isopropylthioxanthone, was shown to speed up substantially the polymerization of the epoxide, with formation within seconds of two fully cured IPNs. In the experiment, the researchers used many compounds, for example, Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7Synthetic Route of C30H56N2O4).

Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate (cas: 41556-26-7) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Synthetic Route of C30H56N2O4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Thin-layer chromatography gradient optimization strategy for wet load adsorption flash chromatography was written by Krecisz, Pawel;Czarnecka, Kamila;Szymanski, Pawel. And the article was included in Journal of Chromatographic Science in 2022.COA of Formula: C21H26N2S2 This article mentions the following:

Chromatog. is one of the most popular methods for the separation of compounds in modern pharmaceutical industry and science. Despite the extensive use of the reversed phase chromatog. in anal. and preparative applications, the normal phase adsorption chromatog. has a special place in purifying post-reaction mixtures or the separation of natural extracts, especially in wet load mode, because of simplicity and high velocity of preparation Complex mixtures, more difficult to sep., require gradient methods to obtain better results of separations These methods can be developed by external software, but the automatic methods are often not very accurate and the neg. impact of wet load application on separation quality is considerable in them. Therefore, we present the thin-layer chromatog. (TLC) gradient optimization strategy for wet load separations to obtain repeatable results of separations for different compounds without worrying about neg. impact of wet loading on separation quality. The strategy provides information about an elution model of desired compound, which is used to develop the gradient method. The strategy also allows to standardize the separation length, because gradient methods performed by the TLC gradient optimization strategy have a very similar duration time in column volumes The method can also be simply scaled because of using the column volume as a base unit in calculations In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2COA of Formula: C21H26N2S2).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.COA of Formula: C21H26N2S2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Modeling and Prediction of Drug Dispersability in Polyvinylpyrrolidone-Vinyl Acetate Copolymer Using a Molecular Descriptor was written by De Boyace, Kevin;Buckner, Ira S.;Gong, Yuchuan;Ju, Tzu-chi Rob;Wildfong, Peter L. D.. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2018.Product Details of 14984-68-0 This article mentions the following:

The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer is described. The mol. descriptor R3m (at. mass weighted 3rd-order autocorrelation index) is shown to be predictive of the formation of amorphous solid dispersions at 2 drug loadings (15% and 75% weight/weight) using 2 preparation methods (melt quenching and solvent evaporation using a rotary evaporator). Cosolidified samples were characterized using a suite of anal. techniques, which included differential scanning calorimetry, powder X-ray diffraction, pair distribution function anal., polarized light microscopy, and hot stage microscopy. Logistic regression was applied, where appropriate, to model the success and failure of compound dispersability in polyvinylpyrrolidone-vinyl acetate copolymer. R3m had combined prediction accuracy greater than 90% for tested samples. The usefulness of this descriptor appears to be associated with the presence of heavy atoms in the mol. structure of the active pharmaceutical ingredient, and their location with respect to the geometric center of the mol. Given the higher electronegativity and at. volume of these types of atoms, it is hypothesized that they may impact the mol. mobility of the active pharmaceutical ingredient, or increase the likelihood of forming nonbonding interactions with the carrier polymer. In the experiment, the researchers used many compounds, for example, 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0Product Details of 14984-68-0).

1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 14984-68-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

5-Sulfonyl-benzimidazoles as selective CB2 agonists – Part 2 was written by Gijsen, Harrie J. M.;De Cleyn, Michel A. J.;Surkyn, Michel;Van Lommen, Guy R. E.;Verbist, Bie M. P.;Nijsen, Marjoleen J. M. A.;Meert, Theo;Van Wauwe, Jean;Aerssens, Jeroen. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.HPLC of Formula: 144222-22-0 This article mentions the following:

In a previous communication, the SAR of a series of potent and selective 5-sulfonylbenzimidazole CB2-receptor agonists was described. The lack of in vivo activity of compounds from this series was attributed to their poor solubility and metabolic stability. In this Letter, we report on further optimization of this series, leading to the relatively polar and peripherically acting CB2 agonists I and II. Although both compounds were not active in acute pain models, the less selective compound I displayed good, sustained activity in a chronic model of neuropathic pain without the tolerance observed with morphine. In addition, both I and II delayed the onset of clin. symptoms in an exptl. model for multiple sclerosis. In the experiment, the researchers used many compounds, for example, 1-Boc-4-(Aminomethyl)piperidine (cas: 144222-22-0HPLC of Formula: 144222-22-0).

1-Boc-4-(Aminomethyl)piperidine (cas: 144222-22-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.HPLC of Formula: 144222-22-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

New directions for emerging therapies in acute myeloid leukemia: the next chapter. was written by Daver, Naval;Wei, Andrew H;Pollyea, Daniel A;Fathi, Amir T;Vyas, Paresh;DiNardo, Courtney D. And the article was included in Blood cancer journal in 2020.Related Products of 1095173-27-5 This article mentions the following:

Conventional therapy for acute myeloid leukemia is composed of remission induction with cytarabine- and anthracycline-containing regimens, followed by consolidation therapy, including allogeneic stem cell transplantation, to prolong remission. In recent years, there has been a significant shift toward the use of novel and effective, target-directed therapies, including inhibitors of mutant FMS-like tyrosine kinase 3 (FLT3) and isocitrate dehydrogenase (IDH), the B-cell lymphoma 2 inhibitor venetoclax, and the hedgehog pathway inhibitor glasdegib. In older patients the combination of a hypomethylating agent or low-dose cytarabine, venetoclax achieved composite response rates that approximate those seen with standard induction regimens in similar populations, but with potentially less toxicity and early mortality. Preclinical data suggest synergy between venetoclax and FLT3- and IDH-targeted therapies, and doublets of venetoclax with inhibitors targeting these mutations have shown promising clinical activity in early stage trials. Triplet regimens involving the hypomethylating agent and venetoclax with FLT3 or IDH1/2 inhibitor, the TP53-modulating agent APR-246 and magrolimab, myeloid cell leukemia-1 inhibitors, or immune therapies such as CD123 antibody-drug conjugates and programmed cell death protein 1 inhibitors are currently being evaluated. It is hoped that such triplets, when applied in appropriate patient subsets, will further enhance remission rates, and more importantly remission durations and survival. In the experiment, the researchers used many compounds, for example, 1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (cas: 1095173-27-5Related Products of 1095173-27-5).

1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (cas: 1095173-27-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Related Products of 1095173-27-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Low-moisture part-skim mozzarella cheese made from blends of camel and bovine milk: Gross composition, proteolysis, functionality, microstructure, and rheological properties was written by Abdalla, Abdelmoneim;Abu-Jdayil, Basim;Alsereidi, Hussah;Hamed, Fathalla;Kamal-Eldin, Afaf;Huppertz, Thom;Ayyash, Mutamed. And the article was included in Journal of Dairy Science in 2022.Reference of 2896-70-0 This article mentions the following:

Camel (CM) milk is used in variety of ways; however, it has inferior gelling properties compared with bovine milk (BM). In this study, we aimed to investigate the physicochem., functional, microstructural, and rheol. properties of low-moisture part-skim (LMPS) mozzarella cheese, made from BM, or BM mixed with 15% CM (CM15%) or 30% CM (CM30%), at various time points (up to 60 d) of storage at 4掳C after manufacture Low-moisture part-skim mozzarella cheeses using CM15% and CM30% had high moisture and total Ca contents, but lower soluble Ca content. Compared with BM cheese, CM15% and CM30% LMPS mozzarella cheese exhibited higher proteolysis rates during storage. Adding CM affected the color properties of LMPS mozzarella cheese manufactured from mixed milk. SEM images showed that the microstructure of CM15% and CM30% cheeses had smooth surfaces, whereas the BM cheese microstructures were rough with granulated surfaces. Low-moisture part-skim mozzarella cheeses using CM15% and CM30% showed significantly lower hardness and chewiness, but higher stringiness than BM cheese. Compared with BM cheese, CM15% and CM30% cheeses showed lower tan 未 levels during temperature surges, suggesting that the addition of CM increased the meltability of LMPS mozzarella cheese during temperature increases. Camel milk addition affected the physicochem., microstructural, and rheol. properties of LMPS mozzarella cheese. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Reference of 2896-70-0).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 2896-70-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists was written by Wijtmans, Maikel;Maussang, David;Sirci, Francesco;Scholten, Danny J.;Canals, Meritxell;Mujic-Delic, Azra;Chong, Milagros;Chatalic, Kristell L. S.;Custers, Hans;Janssen, Elwin;de Graaf, Chris;Smit, Martine J.;de Esch, Iwan J. P.;Leurs, Rob. And the article was included in European Journal of Medicinal Chemistry in 2012.Application of 25560-00-3 This article mentions the following:

The chemokine receptor CXCR7 is an atypical G protein-coupled receptor as it preferentially signals through the 尾-arrestin pathway rather than through G proteins. CXCR7 is thought to be of importance in cancer and the development of CXCR7-targeting ligands is of huge importance to further elucidate the pharmacol. and the therapeutic potential of CXCR7. In the present study, 24 derivatives were synthesized based on a compound scaffold patented by Chemocentryx and obtained CXCR7 ligands with pK_i values ranging from 5.3 to 8.1. SAR studies were supported by computational 3D Fingerprint studies, revealing several important affinity descriptors. Two key compounds I and II (VUF11207 and VUF11403) were found to be high-potency ligands that induce recruitment of 尾-arrestin 2 and subsequent internalization of CXCR7, making them important tool compounds in future CXCR7 research. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Application of 25560-00-3).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application of 25560-00-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Study of the diastereoisomers formed between pipecolic acid N-alkylanilides and 2R,3R-tartaric acid or O,O’-dibenzoyl-2R,3R-tartaric acid. Do the tartaric acids form molecular complexes instead of salts during optical resolutions? was written by Nemak, Katalin;Acx, Maria;Jaszay, Zsuzsa M.;Kozma, David;Fogassy, Elemer. And the article was included in Tetrahedron in 1996.Recommanded Product: 27262-40-4 This article mentions the following:

During the title resolutions the precipitated diastereoisomer was not the salt but a diastereoisomeric complex in 8 cases from 13. The results indicate that tartaric acids may be used as general resolving agents for optical resolution of racemates even having no basic group. In the experiment, the researchers used many compounds, for example, (S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (cas: 27262-40-4Recommanded Product: 27262-40-4).

(S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide (cas: 27262-40-4) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 27262-40-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Effect of solvents on the fluorescence characteristics of 6-anilinopurine and 6-piperidinopurine was written by Abdullah, Zanariah;Bakar, Maizathul Akmam A.;Mohd Shariffuddin, Mohd Adlan;Aiyub, Zaharah. And the article was included in Journal of Ultra Chemistry in 2006.Application of 1928-81-0 This article mentions the following:

6-Chloropurine which was obtained com. was used as the precursor for the preparation of 6-anilinopurine and of 6-piperidinopurine. Fluorescence studies were carried out in 75% ethanol, acetonitrile and Et acetate. Both compounds showed the highest fluorescence peak in Et acetate whereby 6-piperidinopurine showed fluorescence peak at 373 nm, when excited at 315 nm, and 6-anilinopurine showed fluorescence peak at 447 nm when excited at 321 nm. The fluorescence intensity of 6-anilinopurine and 6-piperidinopurine decreased with time. In the experiment, the researchers used many compounds, for example, 6-(Piperidin-1-yl)-9H-purine (cas: 1928-81-0Application of 1928-81-0).

6-(Piperidin-1-yl)-9H-purine (cas: 1928-81-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Application of 1928-81-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem