Category: piperidines

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Novel blue emitting tetra- and pentamethylpiperidin-4-yloxy-1,8-naphthalimides as photoinduced electron transfer based sensors for transition metal ions and protons

Two novel blue emitting 1,8-naphthalimides (1 and 2), containing 2,2,6,6-tetramethylpiperidin-4-yloxy moieties, and newly synthesized under phase transfer catalysis conditions 4-(1,2,2,6,6-pentamethylpiperidin-4-yloxy)-1,8-naphthalimide 7, were configured as “fluorophore-spacer-receptor” systems. Basic photophysical characteristics of the novel fluorescent brighteners were investigated in both DMF and water/DMF (4:1, v/v) solution. Their ability to detect cations was evaluated in the presence of transition metal ions (Cu2+, Pb2+, Zn2+, Ni2+, Co2+) and protons. The presence of metal ions and protons was found to disallow a photoinduced electron transfer leading to an enhancement in the fluorophore emission intensity. The results clearly showed a good sensor activity towards transition metal ions and protons, especially of compound 7, containing tertiary amine receptor. This indicates the potential of the novel compounds as highly efficient “off-on” pH switchers and fluorescent detectors for metal ions.

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Piperidine – Wikipedia,
Piperidine | C5H10303N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 50585-89-2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50585-89-2, Name is Methyl piperidine-3-carboxylate, molecular formula is C7H13NO2. In a Patent, authors is £¬once mentioned of 50585-89-2

IMIDAZOPYRIDAZ1NE COMPOUNDS

The present invention relates to the use of novel compounds of formula (I): wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases

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Application of 173186-91-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 173186-91-9, Name is 1-Benzyl-3,3-dimethylpiperidin-4-one, molecular formula is C14H19NO. In a Article£¬once mentioned of 173186-91-9

Lithiated benzothiophenes and benzofurans require 2-silyl protection to avoid anion migration

2-Trimethylsilyl protection of benzothiophenes and benzofurans prevents anion migration to the 2-position when lithiated species are formed. These lithiated benzothiophenes and benzofurans provide superior results in additions to piperidones. Deprotection is conveniently achieved under acidic conditions. Direct C-7 metalation of benzothiophene is enabled by 2-triisopropylsilyl protection at C-2.

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Piperidine | C5H17630N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of: 3-(Piperidin-1-yl)propanoic acid. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 26371-07-3

A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo

Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy, and the first generation HDAC inhibitors are currently in the clinic. Entirely novel ketone HDAC inhibitors have been developed from the cyclic tetrapeptide apicidin. These compounds show class I subtype selectivity and levels of cellular activity comparable to clinical candidates. A representative example has demonstrated tumor growth inhibition in a human colon HCT-116 carcinoma xenograft model comparable to known inhibitors.

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Piperidine | C5H9153N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ category: piperidines, Which mentioned a new discovery about 3466-80-6

Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening

The elongation condensing enzymes in the bacterial fatty acid biosynthesis pathway represent desirable targets for the design of novel, broad-spectrum antimicrobial agents. A series of substituted benzoxazolinones was identified in this study as a novel class of elongation condensing enzyme (FabB and FabF) inhibitors using a two-step virtual screening approach. Structure activity relationships were developed around the benzoxazolinone scaffold showing that N-substituted benzoxazolinones were most active. The benzoxazolinone scaffold has high chemical tractability making this chemotype suitable for further development of bacterial fatty acid synthesis inhibitors.

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Piperidine | C5H9268N – PubChem

 

Electric Literature of 301673-14-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.301673-14-3, Name is tert-Butyl 4-iodopiperidine-1-carboxylate, molecular formula is C10H18INO2. In a Article£¬once mentioned of 301673-14-3

Cross-coupling of nonactivated primary and secondary alkyl halides with aryl Grignard reagents catalyzed by chiral iron pincer complexes

Iron(III) bisoxazolinylphenylamido (bopa) pincer complexes are efficient precatalysts for the cross-coupling of nonactivated primary and secondary alkyl halides with phenyl Grignard reagents. The reactions proceed at room temperature in moderate to excellent yields. A variety of functional groups can be tolerated. The enantioselectivity of the coupling of secondary alkyl halides is low.

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Piperidine | C5H23445N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of: 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 827026-45-9, Name is 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione, molecular formula is C13H11N3O5. In a Patent, authors is £¬once mentioned of 827026-45-9

AN IMPROVED PROCESS FOR SYNTHESIS OF LENALIDOMIDE

Disclosed herein is an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof.

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Piperidine | C5H22793N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 236406-39-6. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 236406-39-6

Potential GABAB Receptor Antagonists. X* the Synthesis of Further Analogues of Baclofen, Phaclbfen and Saclofen

In an attempt to obtain new compounds with binding activity at the GABAB receptor site, we report the synthesis of 3-amino-2-arylpropanoic acids, and the sulfonic, phosphonic and hydroxamic acid analogues. In addition, we report the synthesis of the isomer of phaclofen, 3-amino-1-(4-chlorophenyl)-propylphosphonic acid, and the higher homologue of baclofen, 5-amino-2-(4-chlorophenyl)pentanoic acid.

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Piperidine | C5H19676N – PubChem

 

Electric Literature of 3433-37-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 3433-37-2, Name is 2-(Hydroxymethyl)piperidine,introducing its new discovery.

NOVEL COMPOUNDS

Ketimines, enamines and oxazolidines are moisture labile functional groups that in the presence of water undergo hydrolysis to yield free amines. Within the art such latent amines have found utility in curable compositions where it is desirable to initiate cure in the presence moisture. A number of novel polyketimines, polyenamines, polymeric oxazolidines and oxazolidines are disclosed. In particular, polymeric compounds of the above classes derived from C6 cyclic diketones and polyamines are reported. Suitable C6 cyclic diketones include cyclohexanediones and quinones. The invention further relates to the applications of the materials, such as in moisture cure adhesives.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Computed Properties of C6H12N2O, Which mentioned a new discovery about 39546-32-2

Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase

To improve the antitumor properties and optimize the pharmaceutical properties including solubility and protein binding of indolin-2-ones, a number of different basic and weakly basic analogues were designed and synthesized. 5-[5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide (12b or SU11248) has been found to show the best overall profile in terms of potency for the VEGF-R2 and PDGF-Rbeta tyrosine kinase at biochemical and cellular levels, solubility, protein binding, and bioavailability. 12b is currently in phase I clinical trials for the treatment of cancers.

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Piperidine | C5H3360N – PubChem