Category: piperazines

Cropping system exerts stronger influence on antibiotic resistance gene assemblages in greenhouse soils than reclaimed wastewater irrigation was written by Liu, Yuan;Neal, Andrew L.;Zhang, Xiaoxian;Fan, Haiyan;Liu, Honglu;Li, Zhongyang. And the article was included in Journal of Hazardous Materials in 2022.Quality Control of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid This article mentions the following:

The effects of reclaimed wastewater (RW) irrigation on the spread of antibiotic resistance genes (ARGs) in soil is modulated by a myriad of biotic and abiotic factors and their relative significance remains vague. We compared microbial communities, assemblages of genes associated with microbial resistance to antibiotics, biocides and metals, and insertion sequences (ISs) in soils following 16 years of irrigation with groundwater (GW), RW or alternately with GW and RW in two greenhouses with different cropping systems, using shotgun metagenome sequencing. The results showed that cropping system exerted greater influence than irrigation on the profile of ISs and resistance genes. This influence was most strongly associated with concentrations of copper, mercury and perfloxacin in the soils. There was no significant difference in soil ARG profiles between continuous RW irrigation and alternating GW and RW irrigation. Proteobacteria, Actinobacteria and Firmicutes and a limited number of ISs were closely associated with the detected ARGs. Most ARGs were found to co-occur with metal and biocide resistance genes through the mechanism of efflux pumps. These findings highlight the significance of understanding and improving crop management in mitigating the dissemination of ARGs in soils irrigated with RW. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3Quality Control of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid).

1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (cas: 113617-63-3) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Quality Control of 1-Cyclopropyl-7-(cis-3,5-dimethylpiperazin-1-yl)-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

SMAD5 signaling: more than meets the nuclei was written by Orlowski, John. And the article was included in Cell Research in 2017.Category: piperazines This article mentions the following:

SMADs are essential transcriptional effectors of transforming growth factor-β (TGFβ)/TGFβ-related signaling that underlies embryonic development and adult homeostasis. A recent study by Fang et al in Cell Research adds to this biol. complexity by demonstrating an atypical cytoplasmic role for SMAD5 in modulating the bioenergetic homeostasis (i.e., glycolysis and mitochondrial respiration) of cells in response to fluctuations in intracellular pH that is independent of receptor signaling. SMAD5 was found to promote not only mitochondrial respiration but also glycolysis in a manner that was influenced by cytoplasmic pH (pHc) and seemingly distinct from the mitochondrial actions of ‘inactive’ cytoplasmic SMAD2. Increases in pHc above 7.2 promoted rapid accumulation of SMAD5 within the cytoplasm, whereas decreases below pHc 7.2 favored its accrual in the nucleus. Further mechanistic studies revealed that pHc-sensing by SMAD5 was conferred by one basic (lysine residues) and two acidic (aspartate and glutamate residues) amino acid clusters in its N-terminal MH1 domain. The pH sensitivity of SMAD5 is intriguing in light of recent reports showing that increases in intracellular pH (pHi) are required for the efficient differentiation of embryonic and adult stem cells. To determine whether there was a functional connection between these seemingly disparate events, the authors performed an elaborate series of experiments that compared the transcriptome profiles of wild-type (WT), SMAD5 knockout (KO) and LDN-193189 (an inhibitor of BMP signaling)-treated human embryonic stem cells (hESCs). The analyses revealed that loss of SMAD5 resulted in the downregulation of a unique subset of genes involved in cellular ion and metabolic homeostasis that were distinct from those affected by blocking BMP signaling. While the mechanism by which cytoplasmic SMAD5 directly stimulates glycolysis is largely resolved, how it regulates mitochondrial morphol. and respiration is less certain. In the experiment, the researchers used many compounds, for example, 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline (cas: 1062368-24-4Category: piperazines).

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline (cas: 1062368-24-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Perception of consumers towards the use of auxiliary labels for over-the-counter and prescription drugs in promoting medication adherence in Luzon was written by Reynoso, Dianne B.;Ayala, Sofia Clarisa P.;Macalincag, Jersey Ann Marie V.;Navarro, Mart Jayzon R.;Paloma, Bon Lorn D.;Racho, Elaine Nicole P.;Andal, Mylene S.;Ecalne, Jan Karlo T.. And the article was included in European Journal of Biomedical and Pharmaceutical Sciences in 2021.Application of 129-74-8 This article mentions the following:

The quant. study aimed to determine Filipino medication consumers′ perception on the use of auxiliary labels on over-the-counter and prescription drugs and assess effectiveness in the three aspects of patient confusion (cognitive, affective, and behavioral). Mode, frequency, and regression anal. were utilized in the data anal. Participants were predominantly women (52.79%), aged 18-25 (68%), and graduates of bachelor′s degrees (42.67%). The consumers′ perception towards the use of auxiliary labels on over-the-counter and prescription drugs is highly accepted in terms of its effectiveness and the three aspects of patient confusion. Consumers perceive them as easy to understand (n = 122, 81.33%), ensure safety (n = 125, 83.33%), proper administration of medication (n = 124, 82.67%), and should be implemented in the Philippines (n = 137, 91.33%). Pharmacists (p = 0.0273) and internet (p = 0.0296) as sources of medication information and being male (p = 0.0182) had a significant relationship with affective and behavioral aspects, resp. Medication consumers prefer the use of auxiliary labels as it aids in medication adherence. Researchers′ recommendations are in-depth qual. research with different settings, backgrounds, and populations for comparable results, and a study on pharmacists′ perception and male gender in the use of auxiliary labels. In the experiment, the researchers used many compounds, for example, 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8Application of 129-74-8).

1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride (cas: 129-74-8) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Application of 129-74-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Mechanisms of linezolid resistance in Staphylococcus capitis with the novel mutation C2128T in the 23S rRNA gene in China was written by Han, Xiao;Zou, Guiling;Liu, Jiaren;Yang, Chun;Du, Xuefei;Chen, Guoyu;Sun, Zhe;Zhang, Xinyu;Sun, Yu;Zhang, Wanying;Jiang, Xiaofeng. And the article was included in BMC Microbiology in 2022.Quality Control of 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins This article mentions the following:

The objective of this study was to investigate the mol. characteristics and potential resistance mechanisms of linezolid-resistant (LZR) Staphylococcus capitis isolates from a tertiary hospital in China. S. capitis isolates were obtained from clin. patient specimens; three of the isolates came from blood cultures and one from the hydrothorax. The agar dilution and E-test methods were used to identify antibiotic resistance. The chloramphenicol-florfenicol resistance (cfr) gene carrier status of the strains was determined by PCR. Whole-genome sequencing (WGS) was used to identify point mutations and L3, L4, and L22 mutations and to study the genetic environment of the cfr gene and the relationships between strains. The 4 isolates obtained in this study were all linezolid-resistant Staphylococcus strains. A similar of susceptibility profile pattern was observed in all four S. capitis strains, each of which exhibited a multidrug-resistant phenotype. A potentially novel mutation, C2128T, was identified, and the cfr genes of S. capitis strains were all pos. Addnl., the same mutations (C2128T and G2600T) were identified in all 23S rRNA sequences of the isolates, whereas mutations were lacking in the L3, L4, and L22 ribosomal proteins. The genetic environments surrounding cfr were identical in all four isolates. A schematic diagram of the phylogenetic tree showed that they were closely related to AYP1020, CR01, and TW2795, and a total of seven drug resistance genes were identified in these strains. The study indicated that the resistance of the Staphylococcus capitis strains to linezolid was caused by multiple mechanisms, and a potential novel mutation, C2128T, that may have an impact on bacterial resistance was identified. In the experiment, the researchers used many compounds, for example, 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1Quality Control of 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins).

8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Quality Control of 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Trends in pharmacologic treatment of chronic idiopathic urticaria from 2016 to 2020 was written by Li, Lily;Landon, Joan E.;Kim, Seoyoung C.. And the article was included in Annals of Allergy, Asthma, & Immunology in 2022.Electric Literature of C21H27ClN2O2 This article mentions the following:

This article is discussed about the trends in pharmacol. treatment of chronic idiopathic urticaria from 2016 to 2020. We examined utilization patterns for omalizumab and other CIUdirected therapies in patients with CIU between July 1, 2016, and Dec. 31, 2020. We identified 63,146 individuals with a diagnosis of CIU during the study period, including 35,060 patients who received prescription CIUdirected therapies (73.1% women, 64.0% White, mean age 51.0 [SD, 18.9] years, 15,820 [25.1%] with comorbid asthma). The percent of individuals receiving omalizumab steadily increased from 25% to 44.3% of all treated patients with CIU between 2016 and 2020 (P < .001). Treatment with montelukast remained stable (range during the study period: 31.5%-34.5% of treated patients, P = .11), whereas oral corticosteroid use decreased over time (39.7% to 31.1%, P < .001). These results indicate that omalizumab use for CIU has been gradually increasing following market availability for this indication. Interestingly, we noted demog. differences in age and race between individuals ever treated with omalizumab, compared with those who never received omalizumab. In patients with concomitant asthma and CIU, we were unable to determine the specific indication for omalizumab administration; however, the overall trends for omalizumab use over time were similar in the subgroup analyses of individuals with and without comorbid asthma. The author concluded that large cohort of privately insured patients receiving CIU-targeted therapies, use of omalizumab has steadily increased whereas prescriptions for sedating H1 receptor antagonists and oral corticosteroids have decreased. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol (cas: 68-88-2Electric Literature of C21H27ClN2O2).

2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol (cas: 68-88-2) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Electric Literature of C21H27ClN2O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage was written by Wang, Di;Li, Danting;Zhang, Yuxin;Chen, Jie;Zhang, Ying;Liao, Chuyao;Qin, Siyuan;Tian, Yuan;Zhang, Zunjian;Xu, Fengguo. And the article was included in Acta Pharmaceutica Sinica B in 2021.Category: piperazines This article mentions the following:

Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal of approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly characterized by the sharp upregulation of tryptophan (Trp)-kynurenine (KYN)-kynurenic acid (KA) axis metabolism Mechanistically, chemotherapy-induced intestinal damage triggered the formation of an interleukin-6 (IL-6)-indoleamine 2,3-dioxygenase 1 (IDO1)-aryl hydrocarbon receptor (AHR) pos. feedback loop, which accelerated kynurenine pathway metabolism in gut. Besides, AHR and G protein-coupled receptor 35 (GPR35) neg. feedback regulates intestinal damage and inflammation to maintain intestinal integrity and homeostasis through gradually sensing kynurenic acid level in gut and macrophage, resp. Moreover, based on virtual screening and biol. verification, vardenafil and linagliptin as GPR35 and AHR agonists resp. were discovered from 2388 approved drugs. Importantly, the results that vardenafil and linagliptin significantly alleviated chemotherapy-induced intestinal toxicity in vivo suggests that chemotherapeutics combined with the two could be a promising therapeutic strategy for cancer patients in clinic. This work highlights GPR35 and AHR as the guardian of kynurenine pathway metabolism and core component of defense responses against intestinal damage. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Category: piperazines).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and inhibitory activity on carbonic anhydrase of some new sulpiride analogs studied by means of a new method was written by Botre, Claudio;Botre, Francesco;Jommi, Giancarlo;Signorini, Roberto. And the article was included in Journal of Medicinal Chemistry in 1986.Computed Properties of C7H14N2 This article mentions the following:

The pharmacol. activity of new sulpiride analogs was studied by a potentiometric technique with a pCO₂ sensor, capable of detecting carbonic anhydrase inhibition at equilibrium conditions. This procedure gives results state as percent of inhibition of enzymic activity. To prove the reliability of the approach and to study structure-activity relationships, several new mols., e.g., sulfamoylbenzamides I (R = Et₂NCH₂CH₂, 2-piperidinoethyl, morpholinoethyl) and piperazine amides II (R¹ = H, allyl, Me₂CHCH₂, EtO₂CCH₂, PhCH₂, etc.) were prepared and tested in comparison with the two sulpiride enantiomers. An inhibition mechanism is discussed in terms of exptl. evidence obtained from the interactions between the mol. structures of the new synthesized compounds and carbonic anhydrase. In the experiment, the researchers used many compounds, for example, (S)-1,4-Diazabicyclo[4.3.0]nonane (cas: 93643-24-4Computed Properties of C7H14N2).

(S)-1,4-Diazabicyclo[4.3.0]nonane (cas: 93643-24-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Computed Properties of C7H14N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

AZD5153 reverses palbociclib resistance in ovarian cancer by inhibiting cell cycle-related proteins and the MAPK/PI3K-AKT pathway was written by Liu, Chen;Huang, Yuhan;Qin, Tianyu;You, Lixin;Lu, Funian;Hu, Dianxing;Xiao, Rourou;Qin, Xu;Guo, Ensong;Yang, Bin;Li, Xi;Fan, Junpeng;Li, Xiong;Fu, Yu;Liu, Si;Wang, Zhuozi;Dou, Yingyu;Wang, Wei;Li, Wenting;Yang, Xiaohang;Liu, Jingbo;Peng, Wenju;Zhang, Li;Cui, Yaoyuan;Sun, Chaoyang;Chen, Gang. And the article was included in Cancer Letters (New York, NY, United States) in 2022.Application of 571190-30-2 This article mentions the following:

The CDK4/6 inhibitor, palbociclib has recently entered clinic-trial stage for breast cancer treatment. However, translating its efficacy to other solid tumors has been challenging, especially for aggressive solid tumors. We found that the effect of palbociclib as a single agent was limited due to primary and acquired resistance in multiple ovarian cancer (OC) models. Among these, patient-derived organoid and xenograft models are two most representative models of drug responsiveness in patients with OC. In preclin. models, this study demonstrated that activated MAPK/PI3K-AKT pathway and cell cycle-related proteins induced the resistance to palbociclib, which was overcome by the addition of the bromodomain protein 4 (BRD4) inhibitor AZD5153. Moreover, this study revealed that AZD5153 and palbociclib had a synergistic lethal effect on inducing the cell cycle arrest and increasing apoptosis, even in RB-deficient cell lines. Based on these results, it is anticipated that this class of drugs, including AZD5153, which inhibit the cell cycle-related protein and MAPK/PI3K-AKT pathway, will exhibit synergistic effects with palbociclib in OC. In the experiment, the researchers used many compounds, for example, 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one (cas: 571190-30-2Application of 571190-30-2).

6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one (cas: 571190-30-2) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Application of 571190-30-2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

RNA helicase DHX37 facilitates liver cancer progression by cooperating with PLRG1 to drive superenhancer-mediated transcription of cyclin D1 was written by Liu, Zhen;Ye, Youqiong;Liu, Yizhe;Liu, Yanfang;Chen, Huifang;Shen, Mengting;Wang, Zhen;Huang, Shenglin;Han, Leng;Chen, Zhiao;He, Xianghuo. And the article was included in Cancer Research in 2022.HPLC of Formula: 571190-30-2 This article mentions the following:

RNA helicases are dysregulated in tumors. Here, we identified DHX37 as one of the top RNA helicase genes with upregulated expression in hepatocellular carcinoma (HCC). DHX37 promoted proliferation of liver cancer cells in vitro and in vivo. Epigenomic profiling of DHX37-knockdown and control HCC cells revealed that DHX37 is associated with superenhancer activity. Mechanistically, DHX37 interacted with pleiotropic regulator 1 (PLRG1) to transcriptionally activate cyclin D1 (CCND1) expression via co-occupation of its promoter and superenhancer elements. DHX37 and PLRG1 promoted liver cancer cell proliferation and contributed to the poor prognosis of patients with HCC. Importantly, CCND1 inhibitors were effective as antiproliferative agents for liver cancer. These results together demonstrate a cooperative mechanistic interaction between DHX37 and PLRG1 that regulates CCND1 expression and promotes liver cancer progression, advancing our understanding of the epigenetic and transcriptional dysregulations mediated by RNA helicases and superenhancers in HCC. In the experiment, the researchers used many compounds, for example, 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one (cas: 571190-30-2HPLC of Formula: 571190-30-2).

6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one (cas: 571190-30-2) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. HPLC of Formula: 571190-30-2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A Novel Series of 4-Piperidinopyridine and 4-Piperidinopyrimidine Inhibitors of 2,3-Oxidosqualene Cyclase-Lanosterol Synthase was written by Brown, George R.;Hollinshead, David M.;Stokes, Elaine S. E.;Waterson, David;Clarke, David S.;Foubister, Alan J.;Glossop, Steven C.;McTaggart, Fergus;Mirrlees, Donald J.;Smith, Graham J.;Wood, Robin. And the article was included in Journal of Medicinal Chemistry in 2000.Quality Control of tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate This article mentions the following:

A novel series of 4-piperidinopyridines and 4-piperidinopyrimidines showed potent and selective inhibition of rat 2,3-oxidosqualene cyclase-lanosterol synthase (OSC) (e.g. 26 IC₅₀ rat = 398±25 nM, human = 112±25 nM) and gave selective oral inhibition of rat cholesterol biosynthesis (26 ED₈₀ = 1.2±0.3 mg/kg, n = 5; HMG-CoA reductase inhibitor simvastatin ED₈₀ = 1.2±0.3 mg/kg, n = 5). The piperidinopyrimidine OSC inhibitors have a significantly lower pK_a than the corresponding pyridine or the previously reported quinuclidine OSC inhibitor series. This indicates that other novel OSC inhibitors may be found in analogs of this series across a broader pK_a range (6.0-9.0). These series may yield novel hypocholesterolemic agents for the treatment of cardiovascular disease. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate (cas: 203520-03-0Quality Control of tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate).

tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate (cas: 203520-03-0) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Quality Control of tert-Butyl 4-(piperidine-4-carbonyl)piperazine-1-carboxylate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics