Category: piperazines

Synthesis of ketoconazole derivatives was written by Ryu, Jae Chun;Lee, Kwang Jae;Lee, Sang Hee. And the article was included in Bulletin of the Korean Chemical Society in 2003.Product Details of 67914-61-8 This article mentions the following:

For the drug master file (DMF) of ketoconazole, four impurities contained in ketoconazole were synthesized. During the synthesis of I, a new synthetic method of 1,4-dihydropyrazine was established. To oxidize the aminoalc. of I to the aminal I, the standard Swern oxidation condition was modified to mask the nucleophilicity of the amino group temporarily using one equivalent of acetic acid. Derivative II was synthesized via regioselective bromination at the I position of the 4-aminophenol derivative of II using Br₂ in the presence of p-TsOH. The etherification of aryl bromide with a phenol derivative compound was accomplished by a modification of the general Cu-mediated reaction condition using excess of the phenol derivative itself as a solvent at elevated temperature (190 °C). In the experiment, the researchers used many compounds, for example, rel-1-(4-(((2R,4S)-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine (cas: 67914-61-8Product Details of 67914-61-8).

rel-1-(4-(((2R,4S)-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine (cas: 67914-61-8) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Product Details of 67914-61-8

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Absorption, distribution and excretion of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796) after single oral administration in rats was written by Kawashima, Tsuneo;Awata, Norio;Satomi, Osamu;Nose, Takashi;Esumi, Yoshio;Mitsugi, Koichi;Katami, Yoshiharu;Ichige, Kazumi;Hirano, Hiromi;Yatsu, Sachiko. And the article was included in Yakubutsu Dotai in 1990.Safety of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride This article mentions the following:

The absorption, distribution and excretion of the Ca blocker KB-2796 were studied in male and female rats after single oral administration of [¹⁴C]KB-2796. The maximum blood concentration of radioactivity appeared at 1 h after administration to male rats at 2 mg/kg and the secondary peak occurred at 12 h after dosing. Thereafter the blood concentrations decreased with the terminal half-life of 42.9 h. The blood concentrations were increased proportionally to the administered doses ranging from 2 to 20 mg/kg. The blood concentrations in female rats decreased more slowly than those in male rats with a terminal half-life of 79.4 h. Male rats excreted 67.4% of the dose in bile and 6.4% in urine within 48 h after dosing; 5.7% of the dose remained in the carcass. The absorption from the intestinal tract was ∼80%. The radioactivity was mainly excreted in feces via bile and partly underwent enterohepatic circulation. The biliary excretion in female rats was lower than that in male rats and the radioactivity was slowly eliminated from the body. Tissue concentrations of radioactivity were over 3-times higher than the plasma concentrations except for the concentrations in the blood and eyeball at 6 h after administration to male rats. High levels of radioactivity were found in the lung, liver, and fat, and disappeared slowly from tissues. Tissue concentrations in female rats were higher than those in male rats. The plasma protein binding in vitro was independent of the concentration (0.04-1 μg/mL) and was about 60% in rats and 80% in humans. In vivo, 69.5-82% of radioactivity was bound to protein of male rat plasma collected 1-24 h after administration. In the experiment, the researchers used many compounds, for example, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7Safety of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride).

1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (cas: 101477-54-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Safety of 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Development and validation of HPLC/DAD method for simultaneously determination of six prohibited substances in model matrices was written by Zaharieva, Zdravka;Tanev, Dimitar;Danalev, Dancho. And the article was included in Acta Chromatographica in 2020.HPLC of Formula: 224785-90-4 This article mentions the following:

The authorities have identified an emerging trend where over-the-counter products, represented as dietary supplements, contain hidden active ingredients that could be harmful. Consumers may unknowingly take products laced with varying quantities of approved prescription drug ingredients, controlled substances, and untested and unstudied pharmaceutically active ingredients. Hidden ingredients are increasingly becoming a problem in products promoted for sexual enhancement, weight loss, or bodybuilding. The tests have revealed the presence of some undesired substances like sildenafil, tadalafil, vardenafil, and their analogs in tainted sexual enhancement products. The content of these substances is usually around the daily curative dose. A simple high-performance liquid chromatog. (HPLC) method for simultaneously determination of sildenafil, vardenafil, tadalafil, dapoxetine, yohimbine, and sibutramine was developed and validated. InfinityLab Poroshell 120 EC-C18 (150 ‘4.6 mm ‘4μm particles) was used, as well as a diode-array detector (DAD) at 230 nm, and a gradient flow with 0.030 M ammonium acetate buffer and acetonitrile. The method is linear in the following range: 2.5-37.5μg/mL for yohimbine, 2.06-30.9μg/ mL for vardenafil, 2.0-30.0μg/mL for sildenafil, 3.1-46.5μg/mL for tadalafil, 1.98-29.7μg/mL for dapoxetine, and 2.2-66.0μg/mL for sibutramine. The linearity coefficient is R2 = 1 for all substances. Model matrixes were spiked, and the anal. recoveries for all substances are in the range 97.5%-99.5%. The method exhibited an upper hand compared with previously reported methods in terms of speed and simplicity. Addnl., the mobile phase (also used as extracting, column washing, and diluting solvent) was composed of only buffer and acetonitrile, which rendered the method much cheaper than others. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4HPLC of Formula: 224785-90-4).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.HPLC of Formula: 224785-90-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of tumor growth and tumor angiogenesis of mouse ehrlich ascites tumor in vivo was written by Ananda Kumar, C. S.;Chandru, H.;Sharada, A. C.;Thimmegowda, N. R.;Benaka Prasad, S. B.;Kumar, M. Karuna;Rangappa, K. S.. And the article was included in Medicinal Chemistry in 2008.Reference of 142-64-3 This article mentions the following:

A series of novel 1-benzhydryl-sulfonyl-piperazine derivatives 3(a-e) were synthesized by nucleophilic substitution reaction of 1-benzhydryl-piperazine with different sulfonyl chlorides and were characterized by ¹H NMR, LC/MS, FTIR and elemental anal. In the present study, the compounds 3(a-e) exhibited in vivo inhibition of Ehrlich ascites tumor (EAT) cell growth and increased the Median Survival Time (MST) and %ILS of EAT bearing mice. Further treatment of derivatives in vivo resulted in reduction of EAT cell number and ascites formation. The efficacy of the derivatives to inhibit the angiogenesis in vivo was evaluated in tumor bearing mice peritoneum and chorio allantoic membrane (CAM) model. The compounds suppressed the blood vessel formation in vivo in mice peritoneum and in CAM. Among the compounds studied, 3e demonstrated highest tumor inhibitory and anti-angiogenic effects against mouse tumor. However, this phenomenon needs detailed investigation. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Reference of 142-64-3).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 142-64-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

The effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews was written by Pyrgidis, Nikolaos;Mykoniatis, Ioannis;Haidich, Anna-Bettina;Tirta, Maria;Talimtzi, Persefoni;Kalyvianakis, Dimitrios;Ouranidis, Andreas;Hatzichristou, Dimitrios. And the article was included in Frontiers in Pharmacology in 2021.SDS of cas: 224785-90-4 This article mentions the following:

Multiple systematic reviews explore the effect of phosphodiesterase type 5 (PDE5) inhibitors on erectile dysfunction (ED), with each study addressing specific outcomes. However, physicians and policymakers require a holistic approach of this topic. To summarize the current evidence regarding the efficacy and safety of PDE5 inhibitors for the management of ED through an overview of systematic reviews. Studies were identified by searching PubMed, Web of Science, Cochrane Library and Scopus databases, as well as sources of gray literature until June 12, 2021 (PROSPERO: CRD42020216754). We considered systematic reviews, meta-analyses or network meta-analyses of randomized trials that provided outcomes about the efficacy and safety of any approved PDE5 inhibitor (avanafil, sildenafil, tadalafil and vardenafil). We constructed forest plots for meta-analytic effects regarding the change in erectile function, adverse events and dropouts after administration of PDE5 inhibitors in the general population and in specific patient groups. We included 23 studies with 154,796 participants and a total of 258 meta-analytic effects. Sildenafil 25 mg [Weighted Mean Difference (WMD): 13.08, 95% Confidence Interval (CI): 10.1-16.06] seemed to be statistically superior to all interventions in improving erectile function compared to placebo, but studies with low-dose sildenafil are lacking. Moreover, comparing among different PDE5 inhibitors, sildenafil 50 mg or sildenafil 100 mg were considered the most effective compounds in the general population. The latter derived, however, predominantly from indirect comparisons among different PDE5 inhibitors. Still, sildenafil 100 mg was associated with more treatment-related adverse events and dropouts. Interestingly, low-dose daily tadalafil may be more effective than high-dose on-demand tadalafil (WMD: 1.24, 95% CI: 0.03-2.44). Furthermore, testosterone and PDE5 inhibitors in patients with ED and hypogonadism seem to further improve symptoms, while the addition of a-blockers in patients with urinary symptoms treated with PDE5 inhibitors does not provide addnl. benefits (WMD: -0.8, 95% CI: -1.65-0.06). Although the efficacy and safety of PDE5 inhibitors, compared to placebo, is well-documented, the existing evidence comparing different PDE5 inhibitors is low. Therefore, high-quality, head-to-head, trials comparing different PDE5 inhibitors are necessary to determine their ideal dosage and formulation based on their safety and efficacy profile. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4SDS of cas: 224785-90-4).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.SDS of cas: 224785-90-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Microwave-assisted extraction followed by salting-out phase separation for hierarchical screening of illegal adulterants in aphrodisiac health products by multi-dimensional fingerprint profiling analysis was written by Wang, Ke;Jin, Peiyi;Pi, Jiaju;Xie, Xiujuan;Zhang, Yi;Yue, Zhenfeng;Mai, Xiaoman;Fan, Huajun;Zhang, Wei. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2021.HPLC of Formula: 224785-90-4 This article mentions the following:

A novel method for hierarchical screening of illegal adulterants in Fur seal ginseng pills (FSGP) products was developed by microwave-assisted extraction (MAE) coupled to salting-out assisted liquid-liquid extraction (SALLE) with multi-dimensional fingerprint profiling anal. Using a homogeneous system formed by di-Me carbonate (DMC) and water as the extractant, the MAE conditions were investigated to maximize extraction recoveries, followed by addition of ammonium sulfate to induce DMC phase separation for SALLE enrichment of 16 potentially illegal adulterants such as phosphodiesterase type-5 inhibitors, androgens, α receptor antagonists and yohimbine etc. By means of high-performance liquid chromatog. (HPLC) with diode array detection (DAD) and fluorescence detection (FLD), multi-dimensional fingerprints were acquired by multi-wavelength detection to highlight the signals of the potentially illegal adulterants and reduce or remove interferences from the sample matrix. For high accuracy and reliability, a hierarchical screening strategy was designed by multi-dimensional fingerprinting profiling anal. (MDFPA). The method exhibited proper identification and quantification performance, and it was successfully applied to screening of illegal adulterants in 18 batches of the samples through the step-by-step MDFPA. Also, the results were further confirmed by ultra high-performance liquid chromatog.-quadrupole-orbitrap mass spectrometry (UHPLC-Q-Orbitrap/MS). The proposed method was proved to be a green, efficient and reliable alternative to monitoring aphrodisiac health products. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4HPLC of Formula: 224785-90-4).

2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).HPLC of Formula: 224785-90-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs was written by Lin, Pei-Ying;Chang, Yu-Jung;Chen, Yu-Chen;Lin, Chin-Hung;Erkekoglu, Pinar;Chao, Ming-Wei;Tseng, Chia-Yi. And the article was included in PLoS One in 2018.Reference of 316-81-4 This article mentions the following:

Here we report a novel multi-methodol. approach to identify opportunities for drug repositioning. We performed analyses of real-world data (RWD) acquired from the FAERS and the claims database maintained by the JMDC. These analyses were followed by cross-validation through bioinformatics analyses of gene expression data. Inverse associations revealed using DPA and SSA were used to detect potential drug-repositioning signals. To evaluate the validity of the approach, we conducted a feasibility study to identify marketed drugs with the potential for treating inflammatory bowel disease (IBD). Primary analyses of the FAERS and JMDC claims databases identified psycholeptics such as haloperidol, diazepam, and hydroxyzine as candidates that may improve the treatment of IBD. To further investigate the mechanistic relevance between hit compounds and disease pathol., we conducted bioinformatics analyses of the associations of the gene expression profiles of these compounds with disease. We identified common biol. features among genes differentially expressed with or without compound treatment as well as disease-perturbation data available from open sources, which strengthened the mechanistic rationale of our initial findings. Integrative anal. of RWD such as those available from adverse-event databases, claims databases, and transcriptome analyses represent an effective approach that adds value to efficiently identifying potential novel therapeutic opportunities. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Reference of 316-81-4).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Reference of 316-81-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Crosstalk Between Apoptosis and Autophagy Is Regulated by the Arginylated BiP/Beclin-1/p62 Complex was written by Song, Xinxin;Lee, Dae-Hee;Dilly, Ashok-Kumar;Lee, Young-Sun;Choudry, Haroon Asif;Kwon, Yong Tae;Bartlett, David L.;Lee, Yong J.. And the article was included in Molecular Cancer Research in 2018.Computed Properties of C19H21F3N6 This article mentions the following:

Emerging evidence demonstrates that autophagy and apoptosis are interconnected and their interplay greatly affects cell death. However, the key regulators in this crosstalk remain elusive. Therefore, the role of N-terminal arginylated BiP (R-BiP)/Beclin-1/p62 complex was examined in the crosstalk between apoptosis and autophagy during combination chemotherapy with mitomycin C and bortezomib using immunoblot, immunoprecipitation, and cellular imaging assays in wild-type (WT) and genetically engineered colorectal cancer cells. Bortezomib combined with mitomycin C synergistically induced cytotoxicity and apoptosis rather than autophagy. Dephosphorylation of Beclin-1 resulted in increased cleavage of Beclin-1 and disruption of the R-BiP/Beclin-1/p62 complex, which led to switching autophagy to the synergistic induction of apoptosis. Importantly, the combination significantly suppressed LS174T i.p. xenograft tumor growth, induced Akt inactivation and Beclin-1 cleavage, and decreased autophagy in vivo. Moreover, the tumoricidal efficacy of the combinatorial treatment was less effective, in vitro and in vivo, in HCT116 tumors harboring a Beclin-1 caspase 8 cleavage site mutant knock-in. Implications: This study uncovers that the R-BiP/Beclin-1/p62 complex has an important role in the crosstalk between apoptosis and autophagy. The results also propose how mono-drug resistance can be overcome using potent combinations to improve anticancer therapy. In the experiment, the researchers used many compounds, for example, 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole (cas: 1255517-76-0Computed Properties of C19H21F3N6).

2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole (cas: 1255517-76-0) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Computed Properties of C19H21F3N6

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Rifapentine and isoniazid for prevention of tuberculosis in people with diabetes (PROTID): protocol for a randomised controlled trial was written by Ntinginya, Nyanda Elias;te Brake, Lindsey;Sabi, Issa;Chamba, Nyasatu;Kilonzo, Kajiru;Laizer, Sweetness;Andia-Biraro, Irene;Kibirige, Davis;Kyazze, Andrew Peter;Ninsiima, Sandra;Critchley, Julia A.;Romeo, Renee;van de Maat, Josephine;Olomi, Willyhelmina;Mrema, Lucy;Magombola, David;Mwayula, Issakwisa Habakkuk;Sharples, Katrina;Hill, Philip C.;van Crevel, Reinout;On behalf of the PROTID Consortium. And the article was included in Trials in 2022.Recommanded Product: 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins This article mentions the following:

Diabetes mellitus (DM) increases the risk of tuberculosis (TB) and will hamper global TB control due to the dramatic rise in type 2 DM in TB-endemic settings. In this trial, we will examine the efficacy and safety of TB preventive therapy against the development of TB disease in people with DM who have latent TB infection (LTBI), with a 12-wk course of rifapentine and isoniazid (3HP). The ‘Prevention of tuberculosis in diabetes mellitus (PROTID) consortium will randomise 3000 HIV-neg. eligible adults with DM and LTBI, as evidenced by a pos. tuberculin skin test or interferon gamma release assay, to 12 wk of 3HP or placebo. Participants will be recruited through screening adult patients attending DM clinics at referral hospitals in Tanzania and Uganda. Patients with previous TB disease or treatment with a rifamycin medication or isoniazid (INH) in the previous 2 years will be excluded. The primary outcome is the occurrence of definite or probable TB disease; secondary outcome measures include adverse events, all-cause mortality and treatment completion. The primary efficacy anal. will be intention-to-treat; per-protocol analyses will also be carried out. We will estimate the ratio of TB incidence rates in intervention and control groups, adjusting for the study site using Poisson regression. Results will be reported as efficacy estimates (1-rate ratio). Cumulative incidence rates allowing for death as a competing risk will also be reported. Approx. 1000 LTBI-neg., HIV-neg. participants will be enrolled consecutively into a parallel cohort study to compare the incidence of TB in people with DM who are LTBI neg. vs pos. A number of sub-studies will be conducted among others to examine the prevalence of LTBI and active TB, estimate the population impact and cost-effectiveness of LTBI treatment in people living with DM in these African countries and address gaps in the prevention and therapeutic management of combined TB-DM. PROTID is anticipated to generate key evidence to guide decisions over the use of TB preventive treatment among people with DM as an important target group for better global TB control. In the experiment, the researchers used many compounds, for example, 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1Recommanded Product: 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins).

8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins (cas: 13292-46-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Recommanded Product: 8-(n-(4-methyl-1-piperazinyl)formidoyl)-rifomycins

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis of piperazine and its salts was written by Krishnan, V.;Muthkumaran, A.;Udupa, H. V. K.. And the article was included in Indian Journal of Technology in 1975.Electric Literature of C4H12Cl2N2 This article mentions the following:

Dioxopiperazine was prepared from glycine and then reduced electrolytically at low temperature to piperazine at Pb and Cu amalgamated electrodes. Piperazine dihydrochloride and citrate were prepared Zn dust distillation of piperazine gave pyrazine. In the experiment, the researchers used many compounds, for example, Piperazine Dihydrochloride (cas: 142-64-3Electric Literature of C4H12Cl2N2).

Piperazine Dihydrochloride (cas: 142-64-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C4H12Cl2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics