Category: 98977-36-7

Some tips on 98977-36-7

98977-36-7 1-Boc-3-Piperidinone 2756825, apiperidines compound, is more and more widely used in various.

98977-36-7,98977-36-7, 1-Boc-3-Piperidinone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The reaction mixture containing 200 mM substrate, 1mM NAD+, 5% (v/v) 2-propanol and 10mg crude enzyme READH in 1mL potassium phosphate buffer (100mM, pH 7.0) was incubated at 50 C. For ChKRED20, 40% (v/v) 2-propanol and a reaction temperature of 40 C were applied instead. The reaction was monitored by TLC, and terminated by extracting with methyl tert-butyl ether (1 mL). The organic extract was dried over anhydrous sodium sulfate and concentrated. The samples were subjected to chiral HPLC to determine the conversion and enantiomeric excess. The products were purified by silica gel column chromatography, and identified by NMR analysis, optical rotation measurements and mass spectrometry.

98977-36-7 1-Boc-3-Piperidinone 2756825, apiperidines compound, is more and more widely used in various.

Reference£º
Article; Li, Chao; Liu, Yan; Pei, Xiao-Qiong; Wu, Zhong-Liu; Process Biochemistry; vol. 56; (2017); p. 90 – 97;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 98977-36-7

The synthetic route of 98977-36-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98977-36-7,1-Boc-3-Piperidinone,as a common compound, the synthetic route is as follows.,98977-36-7

Potassium tert-butoxide (0.971 g),A mixture of tetrahydrofuran (25 mL) and methyltriphenylphosphonium iodide (3.50 g, CAS number: 2065-66-9) was stirred at room temperature for 1 hour. Tert-butyl 3-oxopiperidine-1-carboxylate (1.50 g,A solution of CAS number: 98977-36-7) in tetrahydrofuran (15 mL) was added dropwise, and the mixture was stirred at room temperature overnight. After adding a saturated aqueous solution of ammonium chloride to the reaction solution, the reaction mixture was extracted with ethyl acetate.The organic layer was washed with saturated saline and dried over anhydrous sodium sulfate.After filtration and concentration under reduced pressure, the obtained residue was subjected to silica gel column chromatography (n-hexane / ethyl acetate) to give the title compound (0.994 g) as an oil.

The synthetic route of 98977-36-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Healthcare Co Ltd; Naito, Hiroyuki; Suzuki, Takayuki; Murata, Takeshi; Kawai, Junya; Higuchi, Saito; (99 pag.)JP2020/45306; (2020); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem