Category: 969-33-5

He, Mingchao et al. published their research in Zhongguo Yaoye in 2006 | CAS: 969-33-5

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride

Preparation and quality control of compound cyproheptadine hydrochloride gel was written by He, Mingchao;Wang, Zhongshu. And the article was included in Zhongguo Yaoye in 2006.Application In Synthesis of 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride This article mentions the following:

The gel contained carbomer-940 as the base, triethanolamine as pH adjuster and ethylparaben as preservative. The contents of cyproheptadine hydrochloride (Cph) and dexamethasone acetate (Dxm) in gel were determined by dual-wavelength spectrophotometry and HPLC resp. The gel exhibited fine consistency and moderate viscosity. The average content of Cph in the gel was 101.29% with an average recovery of 101.56% (RSD = 1.90%). The average content of Dxm in the gel was 99.20% with an average recovery of 99.44% (RSD = 2.46%). In the experiment, the researchers used many compounds, for example, 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5Application In Synthesis of 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride).

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Madjda, Benguechoua et al. published their research in Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry in 2021 | CAS: 969-33-5

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride

In Silico and In Vitro Studies of the Inhibitory Effect of Antihistamine Drug Cyproheptadine Hydrochloride on Human Salivary Alpha Amylase was written by Madjda, Benguechoua;Khedidja, Benarous;Samira, Nia;Mohamed, Yousfi. And the article was included in Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry in 2021.Recommanded Product: 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride This article mentions the following:

For the first time, the inhibitory effects on the human salivary alpha-amylase activity of the anti-inflammatory drugs indomethacin, diclofenac sodium, ketoprofen, diclofenac potassium, diclofenac, triamcinolone acetonide, and the antihistamine drugs levocetirizine dihydrochloride, desloratadine, cycloheptadine hydrochloride, have been investigated to confirm the other properties of these drugs. This study aimed to determine the effect of nine known drugs on human salivary a-amylase in vitro and the nature of interactions with structure-activity relationship using mol. docking experiments The inhibition of human salivary alpha amylase by the six anti-inflammatory and three antihistamine drugs has been carried out using the new method that has been proved in our previous work. Mol. docking has been achieved for the first time for these drugs using the Auto- Dock Vina program. Cyproheptadine hydrochloride presented the highest inhibitory activity against a-amylase with IC50 = 0.7 mg/mL, while the other drugs showed weak activities (IC50 > 2 mg/mL). We conclude that Cyproheptadine hydrochloride, which was studied by docking experiments, exhibited the best inhibitory activity on salivary a-amylase in vitro & in silico. In the experiment, the researchers used many compounds, for example, 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5Recommanded Product: 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride).

4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (cas: 969-33-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Recommanded Product: 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem