Category: 959918-19-5

Schwaid, Adam G. published the artcileDevelopment of a selective activity-based probe for glycosylated LIPA, Synthetic Route of 959918-19-5, the main research area is lysosomal acid lipase glycosylation activity probe; Activity based protein profiling; Glycosylation; LAL; LIPA; Lysosomal acid lipase; Serine hydrolase.

Loss of LIPA activity leads to diseases such as Wolman’s Disease and Cholesterol Ester Storage Disease. While it is possible to measure defects in LIPA protein levels, it is difficult to directly measure LIPA activity in cells. In order to measure LIPA activity directly we developed a LIPA specific activity based probe. LIPA is heavily glycosylated although it is unclear how glycosylation affects LIPA activity or function. Our probe is specific for a glycosylated form of LIPA in cells, although it labels purified LIPA regardless of glycosylation.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 959918-19-5 belongs to class piperidines, name is 3-Ethynylpiperidine hydrochloride, and the molecular formula is C7H12ClN, Synthetic Route of 959918-19-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Reference of 959918-19-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.959918-19-5, Name is 3-Ethynylpiperidine hydrochloride, molecular formula is C7H12ClN. In a Patent，once mentioned of 959918-19-5

Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune disease, defects of bone metabolism and/or cancer, and are particularly useful in the treatment of osteoarthritis (OA), pain, and pain associated with OA. Trk inhibitors are also useful for inhibiting tropomyosin-related kinase A (TrkA), tropomyosin-related kinase B (TrkB), tropomyosin-related kinase C (TrkC), and/or c-FMS (the cellular receptor for colony stimulating factor-1 (CSF-1)).

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Reference of 959918-19-5, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 959918-19-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H8293N – PubChem