Category: 95533-25-8

Safety of Methyl 2-(1-methylpiperidin-4-yl)acetateOn May 3, 1985 ,《Synthetic applications of 2-cyano-1,2,3,6-tetrahydropyridines. 2. Synthesis of isodasycarpidone and related systems, the ervitsine skeleton and its benzo analog》 appeared in Journal of Organic Chemistry. The author of the article were Bosch, Joan; Rubiralta, Mario; Domingo, Antonio; Bolos, Jordi; Linares, Ana; Minguillon, Cristina; Amat, Mercedes; Bonjoch, Josep. The article conveys some information:

The synthesis of isodasycarpidone (I, R = Me, R1 = Et, R2 = H) N-demethylisodasycaripdone (I, R = H, R1 = Et, R2 = H) and their epi derivatives I (R = Me, R1 = H, R2 = Et; R = R1 = H, R2 = Et) is described. The condensation of an appropriate 2-cyano-1,2,3,6-tetrahydropyridine with indole and the conjugate addition of diethylcopper(I) magnesium bromide to the resulting α,β-unsaturated esters constitute the key steps of this synthesis. A similar condensation from methyl-2-cyano-1-methyl-1,2,3,6-tetrahydropyridine-4-acetate and indolylmagnesium iodide or (m-methoxyphenyl)magnesium bromide, followed by catalytic hydrogenation, hydrolysis, and cyclization by polyphosphoric acid establishes synthetic routes to the tetracyclic framework (II) of the indole alkaloid ervitsine and its benzo analog III. The experimental process involved the reaction of Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8Safety of Methyl 2-(1-methylpiperidin-4-yl)acetate)

Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Safety of Methyl 2-(1-methylpiperidin-4-yl)acetate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sternfeld, Francine; Baker, Raymond; Broughton, Howard B.; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Beer, Margaret; Stanton, Josephine a. published their research in Bioorganic & Medicinal Chemistry Letters on August 6 ,1996. The article was titled 《The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogs: potent and selective agonists for 5-HT1D receptors》.COA of Formula: C9H17NO2 The article contains the following contents:

Optimization of a series of 5-(heterocyclyl)tryptamines led to the identification of the sym. substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole I is the most potent and selective, orally bioavailable, 5-HT1D receptor agonist identified to date, showing an order of magnitude greater potency than the clin. compound sumatriptan with improved subtype selectivity. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8COA of Formula: C9H17NO2)

Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.COA of Formula: C9H17NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sternfeld, Francine; Baker, Raymond; Broughton, Howard B.; Guiblin, Alexander R.; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Beer, Margaret; Stanton, Josephine a. published their research in Bioorganic & Medicinal Chemistry Letters on August 6 ,1996. The article was titled 《The chemical evolution of N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethylamine (L-741,604) and analogs: potent and selective agonists for 5-HT1D receptors》.Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate The article contains the following contents:

Optimization of a series of 5-(heterocyclyl)tryptamines led to the identification of the sym. substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole I is the most potent and selective, orally bioavailable, 5-HT1D receptor agonist identified to date, showing an order of magnitude greater potency than the clin. compound sumatriptan with improved subtype selectivity. The experimental part of the paper was very detailed, including the reaction process of Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate)

Methyl 2-(1-methylpiperidin-4-yl)acetate(cas: 95533-25-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Reference of Methyl 2-(1-methylpiperidin-4-yl)acetate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem