923565-91-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.923565-91-7,N-(3-Fluorophenyl)piperidin-4-amine hydrochloride,as a common compound, the synthetic route is as follows.
Description 19: 1,1-Dimethylethyl (2S)-4-{[4-(2-{4-[(3-fluorophenyl)amino]-1-piperidinyl}-2-oxo- ethyl)phenyl]methyl}-2-methyl-1-piperazinecarboxylate (D19). A mixture of D18 (27.8g, 79.8mmol), /V-p^dimethylaminot°ropylJ-Lambda/1- ethylcarbodiimide hydrochloride (22.9g, 119.7mmol), 1-hydroxybenzotriazole hydrate (16.2g, 119.7mmol), triethylamine (45ml, 319.1mmol) and D56b hydrochloride salt (18.4g, 79.8mmol) in dry DMF (400ml) was stirred at room temperature overnight. The solvent was removed in vacuo and the residue re-dissolved in DCM (300ml), washed with 2M NaOH (2x200ml), water (200ml) and brine (200ml). All aqueous washings were combined and back extracted with DCM (2x100ml). The combined organics were dried and concentrated to give a solid which was purified by chromatography (silica pre-washed with 50% EtOAc/hexane). Elution with 70% EtOAc/hexane gave the title compound as a white solid (34.95g). deltaH (CDCI3, 400MHz) 7.28 (2H, d), 7.19 (2H, d), 7.07 (1 H, t), 6.23-6.40 (3H, m), 4.52 (1H, m), 4.17 (1 H, m), 3.78-3.88 (2H, m), 3.74 (2H, s), 3.60 (1 H, d), 3.40 (1 H, d), 3.43 (1 H, m), 3.38 (1 H, d), 3.06-3.17 (2H1 m), 2.89 (1H, m), 2.74 (1 H, m), 2.57 (1H, m), 1.94- EPO
The synthetic route of 923565-91-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXO GROUP LIMITED; WO2007/12479; (2007); A2;,
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