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A simple procedure for amide bond formation using diphenylsilane as a coupling reagent is described. This methodology enables the direct coupling of carboxylic acids with primary and secondary amines, releasing only hydrogen and a siloxane as by-products. Only one equivalent of each partner is needed, providing a more sustainable amidation method producing minimal wastes. This methodology was also extended to the synthesis of peptides and lactams by addition of Huenig’s base (DIPEA) and 4-dimethylaminopyridine (DMAP).
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H16634N – PubChem