Sep 2021 News The important role of 92235-39-7

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 92235-39-7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 92235-39-7, Name is (S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate, molecular formula is C10H18N2O3. In a Article, authors is Sayes, Morgane,once mentioned of 92235-39-7

A simple procedure for amide bond formation using diphenylsilane as a coupling reagent is described. This methodology enables the direct coupling of carboxylic acids with primary and secondary amines, releasing only hydrogen and a siloxane as by-products. Only one equivalent of each partner is needed, providing a more sustainable amidation method producing minimal wastes. This methodology was also extended to the synthesis of peptides and lactams by addition of Huenig’s base (DIPEA) and 4-dimethylaminopyridine (DMAP).

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17/9/2021 News New explortion of 92235-39-7

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A simple and efficient synthesis of L-arginine has been achieved in 12 steps and 24% overall yield. Regioselective reduction and functional group manipulation of the beta-side chain of aspartic acid allowed the preparation of an ornithine derivative, which was then guanylated with a bis-protected 1-guanyl-pyrazole and deprotected to give L-arginine. This approach allows the flexible incorporation of stable isotopes and this is demonstrated using potassium 13C-cyanide, which has resulted in the preparation of 5-13C-L-arginine.

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Piperidine – Wikipedia,
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Properties and Exciting Facts About (S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: C10H18N2O3, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 92235-39-7, Name is (S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate, molecular formula is C10H18N2O3. In a Patent, authors is ,once mentioned of 92235-39-7

The invention relates to a tetrahydroisoquinoline compound, preparation method thereof, pharmaceutical composition and its use. The aforesaid tetrahydroisoquinoline compound can be prepared by the following general formula (1) expressed, the definition of each symbol in the formula is the same as the specification. Formula (1). (by machine translation)

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Properties and Exciting Facts About (S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate

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Two series of conformationally constrained analogues of Pro-Leu-Gly-NH2 (PLG) have been synthesized.In one series of analogues, the Leu-Gly-NH2 dipeptide segment of PLG was replaced with the gamma-lactam residues 3(S)- and 3(R)-amino-2-oxopyrrolidineacetamide and the delta-lactam residue 3(S)-amino-2-oxopiperidineacetamide.The corresponding gamma-lactam analogues of Related Products of 92235-39-7

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent, name: (S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate, Which mentioned a new discovery about 92235-39-7

5-Azaindazole compounds of Formula I, including stereoiso­mers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed

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The synthetic route of 92235-39-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92235-39-7,(S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate,as a common compound, the synthetic route is as follows.

92235-39-7, A. Preparation of 1,1-dimethylethyl [(3S)-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-2-oxo-3-piperidinyl]carbamate. Lithium bis(trimethylsilyl)amide (1 N in THF, 18.9 mL, 18.9 mmol) in THF (9 mL) was added dropwise over 35 min to a solution of 1,1-dimethylethyl ((3S)-2-oxo-3-piperidinyl)carbamate (2.0 g, 9.3 mmol) in THF (160 mL) stirring at ambient temperature under argon. After stirring at ambient temperature for 15 min the reaction was cooled to 0 C. and a solution of 1-(bromoacetyl)pyrrolidine (2.0 g, 10.4 mmol) in THF (27 mL) was then added over 60 min. After stirring at 0 C. for 2 h, the reaction was quenched with 10% KHSO4 and transferred to a separatory funnel with ethyl acetate. The mixture was washed with 10% KHSO4 and brine, dried over magnesium sulfate and concentrated in vacuo to afford 4.0 g of crude product. Column chromatography (silica, acetonitrile) afforded 1,1-dimethylethyl [(3S)-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-2-oxo-3-piperidinyl]carbamate (2.0 g, 66%): 1H-NMR (CDCl3) delta 5.36 (m, 1H), 4.14 (d, J=14.1 Hz, 1H), 4.00 (m, 1 H), 3.71 (d, J=14.1 Hz, 1 H), 3.41-3.24 (m, 6 H), 2.31 (m, 1 H), 1.91-1.70 (m, 6 H), 1.61 (m, 1 H), 1.42 (s, 9 H); 13C-NMR (CDCl3) delta 170.0, 165.6, 155.6, 79.0, 51.5, 49.3, 48.6, 45.6, 45.5, 28.1, 27.6, 25.9, 23.8, 20.6.

The synthetic route of 92235-39-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Stein, Philip D.; O’Connor, Stephen P.; Shi, Yan; Li, Chi; US2002/25957; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Some tips on 92235-39-7

The synthetic route of 92235-39-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92235-39-7,(S)-tert-Butyl (2-oxopiperidin-3-yl)carbamate,as a common compound, the synthetic route is as follows.,92235-39-7

[00209] (.S)-Benzyl 2-(3-((teri-Butoxycarbonyl)amino)-2-oxopiperidin-l-yl)acetate (134). A solution of 0.36 g of 133 (1.68 mmol) in 5 mL of anhydrous THF was added to a suspension of 134 mg (3.36 mmol) of sodium hydride (60% dispersion in mineral oil) in 10 mL of anhydrous THF. The reaction was stirred at room temperature for 15 min, and 280 (403 mg, 1.76 mmol) of benzyl bromoacetate was added. After 5 h stirring at room temperature, 30 mL of EtOAc was added, followed by 20 mL of water. The organic phase was washed with 20 mL of brine, dried over Na2SC>4, filtered and concentrated under reduced pressure to afford an oily residue. The residue was purified by chromatography on a silica gel column (10 chi 2 cm). Elution with 3: 1 hexanes-EtOAc afforded 134 as colorless oil: yield 353 mg (58%); Silica gel TLC ? 0.52 (3: 1 hexanes- EtOAc); ‘H NMR (CDC13) delta 1.35 (s, 9H), 1.47-1.63 (m, 1H), 1.75-1.85 (m, 2H), 2.26- 2.38 (m, 1H), 3.17-3.34 (m, 2H), 4.01 (m AB system, 2H), 3.93-4.07 (m, 1H), 4.99-5.11 (m, 2H), 5.43 (br s, 1H) and 7.16-7.31 (m, 5H); 1 C NMR (CDC13) delta 20.8, 27.8, 28.3, 48.7, 48.9, 51.6, 66.8, 79.3, 128.2, 128.3, 128.5, 135.3, 155.8, 168.6 and 170.3.

The synthetic route of 92235-39-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY; HECHT, Sidney; DEDKOVAL, Larisa; MAINI, Rumit; ROY CHOWDHURY, Sandipan; PAUL, Rakesh; (104 pag.)WO2016/118877; (2016); A1;,
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Piperidine | C5H11N – PubChem