Category: 91419-49-7

91419-49-7, 1-Boc-3-Carbamoylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91419-49-7, 3(B) 3-Cyano-piperidine-1-carboxylic acid tert-butyl ester Phosphorus oxychloride (0.64 mL, 6.89 mmol) was added dropwise at 0 C. to a solution of 3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester (1.58 g, 6.89 mmol) in pyridine (15 mL), under nitrogen atmosphere. After stirring overnight at room temperature, ethyl acetate was added and the solution was washed with 10% HCl (2 times). The phases were separated and the organics were dried over sodium sulphate and evaporated to dryness under reduced pressure. The title compound was used for the next step without further purification. Yield: quantitative; LCMS (RT): 4.48 min (Method A); MS (ES+) gave m/z: 211.1.

The synthetic route of 91419-49-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIKEM RESEARCH SRL; ADDEX PHARMA SA; US2009/215822; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

91419-49-7, 1-Boc-3-Carbamoylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91419-49-7, tert-Butyl 3-carbamothioyIpiperidine-l-carboxylate (92):Amide 91 (2.0 g, 8.76 mmol) and Lawesson’s reagent (1.79 g, 4.42 mmol) were stirred in toluene (45 niL) and the mixture heated to 62 C for 4 hours. The mixture was treated with 5 g of silica gel and 15 mL of methanol, and evaporated to dryness. The solid residue was chromatographed over 30 g of silica gel, eluting with CH2Cl2IMeOH (96:4). The product was chromatographed again, eluting with CH2CbMeOH (97:3) and dried to 1.33 g of 92 as a white foam. MS (ESI) m/z 283 [M+K]+. 1H NMR (CDCl3) delta 1.30-1.50 (m, 10 H), 1.55-1.65 (bs, IH), 1.9-2.0 (m, IH), 2.0-2.2 (m, IH), 2.60-2.75 (bs, IH), 3.0-3.2 (bs, IH), 3.3-3.45 (bs, IH), 3.6-3.95 (m, 2H), 7.43 (bs, 2H).

As the paragraph descriping shows that 91419-49-7 is playing an increasingly important role.

Reference£º
Patent; MITHRIDION, INC.; TWOSE, Trevor, M.; ABRAHAM, Brent, D.; COPP, Richard, R.; FARNHAM, James, G.; HANSON, Seth, A.; HENDRICKSON, Michael, L.; OCKULY, Jeffrey, C.; VERDONE, Melinda, L.; WO2010/102218; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem