Category: 908245-03-4

Related Products of 908245-03-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 908245-03-4, name is Methyl 6-methylpiperidine-3-carboxylate. In an article，Which mentioned a new discovery about 908245-03-4

Muscarinic agonists, which are useful for stimulating muscarinic receptors and treating cognitive disorders, are provided. Methods of synthesizing such agonists also are provided. Also provided are compositions for enhancing cognitive function in subjects such as humans, the compositions comprising a muscarinic agonist or a pharmaceutically suitable form thereof. Also provided are methods of treating animals such as humans by administering such compositions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.908245-03-4. In my other articles, you can also check out more blogs about 908245-03-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H9213N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Computed Properties of C8H15NO2, Which mentioned a new discovery about 908245-03-4

The present invention provides a compound of the general formula (1): wherein one of X and Y is N and the other is an optionally substituted carbon atom, and Z2-Z5 represent one or two nitrogen atoms, as further described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals and as components of pharmaceutical compositions. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds described herein or pharmaceutical compositions comprising such compounds.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 908245-03-4, help many people in the next few years.Computed Properties of C8H15NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H9203N – PubChem

Related Products of 908245-03-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 908245-03-4, Name is Methyl 6-methylpiperidine-3-carboxylate,introducing its new discovery.

The present invention provides a compound of general formula:wherein Z2 -Z6 include one or two nitrogen atoms as described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds.

If you’re interested in learning more about 79815-20-6, below is a message from the blog Manager. Related Products of 908245-03-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H9204N – PubChem

Related Products of 908245-03-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 908245-03-4, name is Methyl 6-methylpiperidine-3-carboxylate. In an article，Which mentioned a new discovery about 908245-03-4

The present invention provides a compound of Formula (I) and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.908245-03-4. In my other articles, you can also check out more blogs about 908245-03-4

Reference：
Piperidine – Wikipedia,
Piperidine | C5H9206N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.908245-03-4,Methyl 6-methylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

908245-03-4, To a dichloromethane solution (40 mL) of methyl 6-methylpiperidine-3-carboxylate (3.90 g) obtained in Step 1, triethylamine (2.64 g) was added, then, a dichloromethane solution (5 mL) of Boc2O (5.68 g) was added while stirring at room temperature. After stirred for 70 hours at room temperature, the reaction mixture was washed with 1 mol/L hydrochloric acid (100 mL). The organic layer was dried with anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, the residue was purified with silica gel column chromatography (hexane/ethyl acetate=100/0 to 13/87) to give 1-tert-butyl 3-methyl-cis-6-methylpiperidine-1,3-dicarboxylate (2.66 g, low polarity) and 1-tert-butyl 3-methyl-trans-6-methylpiperidine-1,3-dicarboxylate (1.39 g, high polarity) respectively as an oil. cis-isomer, 1H NMR (300 MHz, CDCl3) delta 1.13 (d, 3H), 1.46 (s, 9H), 1.50-1.95 (m, 4H), 2.30-2.45 (m, 1H), 2.80-3.00 (m, 1H), 3.69 (s, 3H), 4.15 (br, 1H), 4.40 (br, 1H); trans-isomer, 1H NMR (300 MHz, CDCl3) delta 1.14 (d, 3H), 1.30-1.40 (m, 1H), 1.46 (s, 9H), 1.72-1.96 (m, 2H), 1.96-2.06 (br, 1H), 2.58 (br, 1H), 3.04-3.10 (m, 1H), 3.68 (s, 3H), 4.30-4.45 (m, 2H)

908245-03-4 Methyl 6-methylpiperidine-3-carboxylate 42628698, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; SUMITOMO DAINIPPON PHARMA CO., LTD.; FUSANO, Akira; KOBAYASHI, Tomonori; SAITO, Yasuhiro; KANAI, Toshio; (55 pag.)US2016/221948; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.908245-03-4,Methyl 6-methylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

908245-03-4, To a dichloromethane solution (40 mL) of methyl 6-methylpiperidine-3-carboxylate (3.90 g) obtained in Step 1, triethylamine (2.64 g) was added, then, a dichloromethane solution (5 mL) of Boc2O (5.68 g) was added while stirring at room temperature. After stirred for 70 hours at room temperature, the reaction mixture was washed with 1 mol/L hydrochloric acid (100 mL). The organic layer was dried with anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, the residue was purified with silica gel column chromatography (hexane/ethyl acetate=100/0 to 13/87) to give 1-tert-butyl 3-methyl-cis-6-methylpiperidine-1,3-dicarboxylate (2.66 g, low polarity) and 1-tert-butyl 3-methyl-trans-6-methylpiperidine-1,3-dicarboxylate (1.39 g, high polarity) respectively as an oil. cis-isomer, 1H NMR (300 MHz, CDCl3) delta 1.13 (d, 3H), 1.46 (s, 9H), 1.50-1.95 (m, 4H), 2.30-2.45 (m, 1H), 2.80-3.00 (m, 1H), 3.69 (s, 3H), 4.15 (br, 1H), 4.40 (br, 1H); trans-isomer, 1H NMR (300 MHz, CDCl3) delta 1.14 (d, 3H), 1.30-1.40 (m, 1H), 1.46 (s, 9H), 1.72-1.96 (m, 2H), 1.96-2.06 (br, 1H), 2.58 (br, 1H), 3.04-3.10 (m, 1H), 3.68 (s, 3H), 4.30-4.45 (m, 2H)

908245-03-4 Methyl 6-methylpiperidine-3-carboxylate 42628698, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; SUMITOMO DAINIPPON PHARMA CO., LTD.; FUSANO, Akira; KOBAYASHI, Tomonori; SAITO, Yasuhiro; KANAI, Toshio; (55 pag.)US2016/221948; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.908245-03-4,Methyl 6-methylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

908245-03-4, This residue was dissolved in CH2C12 (30 mL) and chilled in an ice bath. To this stirred solution was added DMAP (0.194 g, 1.59 mmol), followed by TEA (6.64 mL, 47.7 mmol) portion wise. A suspension formed when TEA was added. This mixture was chilled to 15 C. To the resulting suspension was added benzyl chloroformate (2.72 mL, 19 mmol) dropwise over a 15 min period such that the temperature of the mixture was kept at 15- 20 C. After completion of benzyl chloroformate addition, the mixture was stirred chilled with an ice bath for another 30 min and then at ambient temperature for 1 h. This mixture was washed with 100 mL of cold IN HC1. The organic was concentrated in vacuo. The residue was partitioned between toluene (100 mL), MTBE (100 mL), and water (50 mL). The organic was washed with brine, dried over MgS04, filtered, and concentrated in vacuo to give an oil (2.5 g) as the crude (NMR showed ?^3: 1 cis/trans ratio of isomers). Isomer was separated by silica gel column chromatography using gradient elution of EtOAc in hexane and gave 840 mg cis isomer (112) and 450 mg trans isomer (113).

The synthetic route of 908245-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ADVINUS THERAPEUTICS LIMITED; BARAWKAR, Dinesh; BENDE, Tanushree; ZAHLER, Robert; BANDYOPADHYAY, Anish; SARANGTHEM, Robindro Singh; DOSHI, Jignesh; WAMAN, Yogesh; JADHAV, Rushikesh; SINGH, Umesh Prasad; WO2012/127506; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem